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Assessing Stability of Crutch Users by Non-Contact Methods
# Introduction
Estimates from the World Health Organization (WHO) show that over one billion people need one or more assistive devices, with an expectation that these figures will double to beyond two billion by 2050. Among those assistive devices, the two m... |
Diplopia due to acquired Brown syndrome after COVID-19 infection
## Case report
A 31-year-old woman, an intensive care unit nurse, was admitted to the ophthalmology service, Ankara University, School of Medicine, with a complaint of double vision and pain in up-and-left gaze for 4 days. No history of systemic or ocu... |
MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming
BACKGROUND: Mitochondrial dynamics plays an important role in tumour progression. However, how these dynamics integrate tumour metabolism in hepatocellular carcinoma (HCC) metastasis is sti... |
Phase II study of weekly irinotecan and capecitabine treatment in metastatic colorectal cancer patients
Background: The purpose of this phase II study was to evaluate the safety and efficacy of weekly irinotecan and capecitabine (wXELIRI) treatment in patients with metastatic colorectal cancer, specifically the rate o... |
A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation
Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-rela... |
Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the initial rate-limiting step in the degradation of the essential amino acid tryptophan along the kynurenine pathway. When discovered more than 50 years ago, IDO1 was thou... |
Differential Pharmacological Actions of Methadone and Buprenorphine in Human Embryonic Kidney 293 Cells Coexpressing Human μ-Opioid and Opioid Receptor-Like 1 Receptors
Methadone and buprenorphine are used in maintenance therapy for heroin addicts. In this study, we compared their effects on adenylate cyclase (AC) act... |
Follicle Stimulating Hormone is an accurate predictor of azoospermia in childhood cancer survivors
This is the Supplementary Information file, listing the full-text excluded articles together with reasons for exclusion.WHOFull texts excluded for non-specification of WHO guidelines for assessment of azoospermia: [[BenA... |
Air-Stable NaxTMO2 Cathodes for Sodium Storage
Sodium-ion batteries are considered to be the most promising alternative to lithium-ion batteries for large-scale stationary energy storage applications due to the abundant sodium resource in the Earth' crust and as a result, relatively low cost. Sodium layered transition... |
Screening‐Level Estimates of Environmental Release Rates, Predicted Exposures, and Toxic Pressures of Currently Used Chemicals
We describe a procedure to quantify emissions of chemicals for environmental protection, assessment, and management purposes. The procedure uses production and use volumes from registration do... |
Two Cases of Pituitary Stalk Interruption Syndrome in Syrian Children
Pituitary stalk interruption syndrome (PSIS) is an extremely rare cause of growth failure and delayed puberty. It can be diagnosed by magnetic resonance imaging (MRI) of the hypothalamus and pituitary gland, showing an ectopic or absent posterior pi... |
Intrinsic refractive index matched 3D dSTORM with two objectives: Comparison of detection techniques
We have built a setup for 3D single molecule localisation microscopy (SMLM) where a very high resolution is achieved by, firstly, the use of two objectives instead of one and, secondly, minimizing optical aberrations b... |
Randomised Phase II Trial (NCT00637975) Evaluating Activity and Toxicity of Two Different Escalating Strategies for Pregabalin and Oxycodone Combination Therapy for Neuropathic Pain in Cancer Patients
Purpose: Neuropathic pain is commonly associated with cancer. Current treatments include combination opioid and adjuva... |
IFNβ-producing CX3CR1+ macrophages promote T-regulatory cell expansion and tumor growth in the APCmin/+ / Bacteroides fragilis colon cancer model
Increased T-regulatory cell activity drives tumor progression in the compound APC min/+ /enterotoxic Bacteroides fragilis colon cancer model. At the same time, how microbial... |
Genome survey and SSR analysis of Apocynum venetum
Apocynum venetum is an eco-economic plant that exhibits high stress resistance. In the present paper, we carried out a whole-genome survey of A. venetum in order to provide a foundation for its whole-genome sequencing. High-throughput sequencing technology (Illumina N... |
A Multi-Strain Probiotic Formulation Improves Intestinal Barrier Function by the Modulation of Tight and Adherent Junction Proteins
# Introduction
In recent years, scientific research in the fields of gut microbiota and probiotic consumption has risen exponentially, revealing the critical role of microbiota in suppo... |
Population Pharmacokinetic Analysis of Fluticasone Furoate/Umeclidinium/Vilanterol via a Single Inhaler in Patients with COPD
A population pharmacokinetic analysis was conducted from a subset of samples obtained from the Lung Function and Quality of Life Assessment in Chronic Obstructive Pulmonary Disease with Closed ... |
Is Corticospinal Tract Degeneration Caused by Sjögren Syndrome?
A 36-year-old woman with a history of dry eyes and recurrent oral ulcers presented with an 8-month history of progressive motor weakness of both legs. She was documented as experiencing mild weakness (4+/5) of both legs with no sensory loss 2 months after... |
The management of acute and chronic hyponatraemia
Hyponatraemia is the most common electrolyte abnormality encountered in clinical practice; despite this, the work-up and management of hyponatraemia remain suboptimal and varies among different specialist groups. The majority of data comparing hyponatraemia treatments ... |
Dopaminergic and Cholinergic Modulation of Large Scale Networks in silico Using Snudda
Neuromodulation is present throughout the nervous system and serves a critical role for circuit function and dynamics. The computational investigations of neuromodulation in large scale networks require supportive software platforms... |
MicroRNA and Male Infertility: A Potential for Diagnosis
MicroRNAs (miRNAs) are small non-coding single stranded RNA molecules that are physiologically produced in eukaryotic cells to regulate or mostly down-regulate genes by pairing with their complementary base-sequence in related mRNA molecules in the cytoplasm. It... |
Endothelial Protein C Receptor (EPCR), Protease Activated Receptor-1 (PAR-1) and Their Interplay in Cancer Growth and Metastatic Dissemination
Endothelial protein C receptor (EPCR) and protease activated receptor 1 (PAR-1) by themselves play important role in cancer growth and dissemination. Moreover, interactions bet... |
Double intussusception secondary to Meckel’s diverticulum in a seventeen-year-old female: a case report
# Introduction
In 1809, Meckel´s diverticulum (MD) was described as a vestigial embryonic remnant of the omphalomesenteric duct. It is more commonly identified in children, as adults are rarely symptomatic. It is ... |
Price, Availability, and Youth Obesity: Evidence From Bridging the Gap
After a decade of analyzing environmental influences on substance use and its consequences among youth in the United States, the Robert Wood Johnson Foundation's Bridging the Gap program has begun studying the effect of environmental factors on you... |
Mosaic Intrachromosomal Triplication of (12)(p11.2p13) in a Patient with Pallister-Killian Syndrome
Pallister-Killian syndrome (PKS) is a rare genetic disorder usually characterized by mosaic tetrasomy of isochromosome 12p detected in cultured fi broblast cells. We describe here a patient with PKS and intrachromosomal... |
The Reduction of Peripheral Blood CD4+ T Cell Indicates Persistent Organ Failure in Acute Pancreatitis
ObjectiveFew data are available on the potential role of inflammatory mediators and T lymphocytes in persistent organ failure (POF) in acute pancreatitis (AP). We conducted a retrospective study to characterize their... |
Nurse-led, telephone-based follow-up after acute coronary syndrome yields improved risk factors after 36 months: the randomized controlled NAILED-ACS trial
We investigated whether a nurse-led, telephone-based follow-up including medical titration was superior to usual care in improving blood pressure (BP) and low-dens... |
A seed resource for screening functionally redundant genes and isolation of new mutants impaired in CO2 and ABA responses
The identification of homologous genes with functional overlap in forward genetic screens is severely limited. Here, we report the generation of over 14 000 artificial microRNA (amiRNA)-expressing ... |
Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)
Background: Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer'... |
Expanding the spectrum of “mesenchymal” tumors of the central nervous system
This is an open access journal distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license: the work can be used by mentioning the author and the license, but only for no... |
The challenge to verify ceramide's role of apoptosis induction in human cardiomyocytes - a pilot study
Background: Cardioplegia and reperfusion of the myocardium may be associated with cardiomyocyte apoptosis and subsequent myocardial injury. In order to establish a pharmacological strategy for the prevention of these... |
A pretraining domain decomposition method using artificial neural networks to solve elliptic PDE boundary value problems
A pretraining domain decomposition method using artificial neural networks to solve elliptic PDE boundary value problemsJeong-Kweon SeoDeveloping methods of domain decomposition (DDM) has been widel... |
Rapidly progressing subperiosteal orbital abscess: an unexpected complication of a group-A streptococcal pharyngitis in a healthy young patient
Introduction: Complications associated to group-A streptococcal pharyingitis include non-suppurative complications such as acute rheumatic fever and glomerulonephritis and sup... |
Cleavage of Dicer Protein by I7 Protease during Vaccinia Virus Infection
Dicer is the key component in the miRNA pathway. Degradation of Dicer protein is facilitated during vaccinia virus (VV) infection. A C-terminal cleaved product of Dicer protein was detected in the presence of MG132 during VV infection. Thus, it i... |
Analysis of causes for poor persistence of CAR-T cell therapy in vivo
# Introduction
In recent years, great progress has been made in chimeric antigen receptor T cell (CAR-T cell) therapy for hematological and solid tumors, but patients still experience recurrence after treatment. Poor persistence of CAR-T cells in ... |
Evolution of global development cooperation: An analysis of aid flows with hierarchical stochastic block models
Despite considerable scholarly attention on the institutional and normative aspects of development cooperation, its longitudinal dynamics unfolding at the global level have rarely been investigated. Focusing... |
Associations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Study
Background: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood press... |
Characterization of an iPSC line NCHi006-A from a patient with hypoplastic left heart syndrome (HLHS)
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect characterized by underdeveloped structures on the left side of the heart, including hypoplasia of the left ventricle and stenosis or atresia o... |
The cerebellum and its network: Disrupted static and dynamic functional connectivity patterns and cognitive impairment in multiple sclerosis
Background: The impact of cerebellar damage and (dys)function on cognition remains understudied in multiple sclerosis. Objective: To assess the cognitive relevance of cerebellar ... |
Modest Increase in Fertility Consultations in Female Adolescents and Young Adults with Lymphoma: A Population-Based Study
# Introduction
T he adolescent and young adult (AYA) age group, 15-39 years of age, presents unique challenges in oncology. Hematological malignancies (HMs) make up 21%-34% of cancer diagnoses am... |
Setting boundaries for genome-wide heterochromatic DNA deletions through flanking inverted repeats in Tetrahymena thermophila
Eukaryotic cells pack their genomic DNA into euchromatin and heterochromatin. Boundaries between these domains have been shown to be set by boundary elements. In Tetrahymena, heterochromatin do... |
Shexiang Baoxin Pills as an Adjuvant Treatment for Chronic Heart Failure: A System Review and Meta-Analysis
Background. Shexiang Baoxin pills (SXBXP), as a Traditional Chinese Medicine, are widely used for chronic heart failure in China. It is essential to systematically assess the efficacy and safety of SXBXP as an a... |
LDL-cholesterol lowering effect of a new dietary supplement: an open label, controlled, randomized, cross-over clinical trial in patients with mild-to-moderate hypercholesterolemia
Background: Hypercholesterolemia is a major risk factor for cardiovascular disorders and requires specific intervention through an adequat... |
Rad51 paralogs Rad55-Rad57 balance the anti-recombinase Srs2 in Rad51 filament formation
13 0.21 µM RPA, ± 0.4 µM Srs2), and the means (ø) ± 1 sd and distributions of filament length classes are shown. Scale bars: 100 nm. White arrows indicate RPA-ssDNA complexes and red arrows Rad51 filaments.Figure 4. Rad55-Rad57 in... |
Measurement of collateral perfusion in acute stroke: a vessel-encoded arterial spin labeling study
Collateral perfusion is important for sustaining tissue viability in acute ischemic stroke. Conventional techniques for its visualization are invasive, require contrast agents and demonstrate collateral vessels, rather t... |
Pressing needs of biomedical text mining in biocuration and beyond: opportunities and challenges
Citation details: Singhal,A., Leaman,R., Catlett,N., et al. Pressing needs of biomedical text mining in biocuration and beyond: opportunities and challenges.AbstractText mining in the biomedical sciences is rapidly transit... |
Role of Cytokines and Chemokines in Angiogenesis in a Tumor Context
# Introduction
There are two fundamental processes to form blood vessels: vasculogenesis and angiogenesis. Vasculogenesis corresponds to the de novo blood vessel formation, whereas angiogenesis is the formation of new blood vessels from pre-existing... |
eIF3d is an mRNA cap-binding protein required for specialized translation initiation
Eukaryotic mRNAs contain a 5′ cap structure that is crucial for recruitment of the translation machinery and initiation of protein synthesis. mRNA recognition is thought to require direct interactions between eukaryotic initiation fac... |
Comparing the Effects of Oral HIV Self-Testing With Those of Standard HIV Testing for Men Who Have Sex With Men (MSM): A Systematic Review and Meta-Analysis
# Introduction and background
Regular testing is recognized as a key strategy for HIV control. Awareness of one's HIV-positive status results in the reduction o... |
Re-wiring Guilt: How Advancing Neuroscience Encourages Strategic Interventions Over Retributive Justice
The increasing visibility of neuroscience employed in legal contexts has rightfully prompted critical discourse regarding the boundaries of its utility. High profile debates include some extreme positions that eithe... |
HbA1c Levels Are Associated with Chronic Kidney Disease in a Non-Diabetic Adult Population: A Nationwide Survey (KNHANES 2011–2013)
BackgroundMany studies have reported an association between glycated hemoglobin A1c (HbA1c) and metabolic syndrome (MetS) in non-diabetes patients. Each component of MetS is in fact relat... |
Myricetin 3-O-β-D-Galactopyranoside Exhibits Potential Anti-Osteoporotic Properties in Human Bone Marrow-Derived Mesenchymal Stromal Cells via Stimulation of Osteoblastogenesis and Suppression of Adipogenesis
# Introduction
During osteoporosis progression, it was shown that the differential tendencies of bone marrow... |
Clinical characteristics and infectivity of asymptomatic carriers of SARS-CoV-2 (Review)
# Introduction
In December 2019, the first case of pneumonia of unknown etiology was identified in Wuhan, China. Subsequently, the pathogen was isolated and officially named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-... |
Quantitative Particle Uptake by Cells as Analyzed by Different Methods
Figure SI-I.2.1: (a) Schematic diagram of a SNARF-1 dextran loaded PEM pH sensor capsule. (b) Fluorescence microscopy images of sensor capsules under acidic (yellow fluorescence, shown in green false colors) and alkaline (red fluorescence) conditio... |
Health impacts of parental migration on left-behind children and adolescents: a systematic review and meta-analysis
Background Globally, a growing number of children and adolescents are left behind when parents migrate.We investigated the effect of parental migration on the health of left behind-children and adolescen... |
Posterior placoid-like maculopathy and macular hole associated with vitamin A deficiency
A B S T R A C TPurpose: To report a case of bilateral posterior placoid-like maculopathy and a macular hole associated with vitamin A deficiency. Observations: A 72-year-old male presented with nyctalopia and progressive vision lo... |
The impact of the COVID lockdown on alcohol consumption in the Netherlands. The role of living arrangements and social isolation
A B S T R A C TBackground: The COVID-19 pandemic and the subsequent lockdown have a strong impact on health and health behaviours, such as alcohol consumption. Although there is some evidenc... |
Tension pneumothorax as a severe complication of endobronchial ultrasound-guided transbronchial fine needle aspiration of mediastinal lymph nodes
StreszczenieW pracy zaprezentowano opis przypadku odmy opłucnowej prężnej, która wystąpiła u pacjenta z rozedmą pęcherzową i przewlekłą obturacyjną chorobą płuc po wykonaniu... |
Premorbid traumatic stress and veteran responses to the COVID‐19 pandemic
The COVID-19 pandemic has had unprecedented effects on lifestyle stability and physical and mental health. We examined the impact of preexisting posttraumatic stress disorder (PTSD), alcohol use disorder (AUD), and depression on biopsychosocial ... |
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
## A b s t r a c t
Herein we report the discovery and SAR of a nov... |
Genome-Wide Association Study of Relative Telomere Length
Telomere function is essential to maintaining the physical integrity of linear chromosomes and healthy human aging. The probability of forming proper telomere structures depends on the length of the telomeric DNA tract. We attempted to identify common genetic v... |
The emergence of neoadjuvant therapy in advanced melanoma
The discovery of immunotherapy and targeted therapy has introduced new and effective treatment options for advanced melanoma, providing therapeutic options where none existed before. The natural extension of these novel therapies is to identify their role in th... |
Right to health and social justice in Bangladesh: ethical dilemmas and obligations of state and non-state actors to ensure health for urban poor
Background: The world is urbanizing rapidly; more than half the world's population now lives in urban areas, leading to significant transition in lifestyles and social behavi... |
Exploring the applications of hyaluronic acid‐based nanoparticles for diagnosis and treatment of bacterial infections
Hyaluronic acid (HA) has become a topic of significant interest in drug delivery research due to its excellent properties, including biosafety, biodegradability, and nonimmunogenicity. Moreover, due to... |
Clinical valve thrombosis post-transcatheter aortic valve implantation with hypoattenuating leaflet thickening in computed tomography: anticoagulation is the answer
A 59-year-old woman presented to the emergency room in acute pulmonary oedema. Her past medical history included aortic valve replacement in 2005 for seve... |
Urinary Potassium and Kidney Function Decline in the Population—Observational Study
Citation: Cirillo, M.; Bilancio, G.; Cavallo, P.; Palladino, R.; Zulli, E.; Villa, R.; Veneziano, R.; Laurenzi, M. Urinary Potassium and Kidney Function Decline in the Population-Observational Study.Nutrients 2021, 13, 2747. https://
... |
COVID-19 pandemic: health impact of staying at home, social distancing and ‘lockdown’ measures—a systematic review of systematic reviews
A B S T R A C TBackground To systematically review the evidence published in systematic reviews (SR) on the health impact of staying at home, social distancing and lockdown measures.... |
Exercise and Atrial Fibrillation: Some Good News and Some Bad News
Atrial fibrillation (AF) is considered as the most common sustained arrhythmia in adults, whose incidence rate is on the rise due to the increase in the mean age of the global population. In recent years, many efforts have been made to identify effecti... |
Improved power for TB Phase IIa trials using a model-based pharmacokinetic–pharmacodynamic approach compared with commonly used analysis methods
Background:The demand for new anti-TB drugs is high, but development programmes are long and costly. Consequently there is a need for new strategies capable of accelerating t... |
Identifying and prioritizing strategies for comprehensive liver cancer control in Asia
Background: Liver cancer is both common and burdensome in Asia. Effective liver cancer control, however, is hindered by a complex etiology and a lack of coordination across clinical disciplines. We sought to identify strategies for ... |
Primary Pulmonary Hodgkin Lymphoma
Primary pulmonary Hodgkin lymphoma (PPHL) is a rare disease. Herein, we report a case of PPHL with diagnostic concerns encountered during initial evaluation which is of paramount importance to keep the differential diagnosis in cases with high index of suspicion for this rare entity.... |
Biotechnical paving of recombinant enterocin A as the candidate of anti-Listeria agent
Background: Enterocin A is a classic IIa bacteriocin isolated firstly from Enterococcus faecium CTC492 with selective antimicrobial activity against Listeria strains. However, the application of enterocin A as an anti-Listeria agent... |
Depression Predicts All-Cause Mortality
OBJECTIVEdDepression affects up to 20-25% of adults with type 2 diabetes and may increase all-cause mortality, but few well-designed studies have examined the effects of depression on the full range of cardiovascular disease outcomes in type 2 diabetes.RESEARCH DESIGN AND METHOD... |
Evolution of echovirus 11 in a chronically infected immunodeficient patient
Deep sequencing was used to determine complete nucleotide sequences of echovirus 11 (EV11) strains isolated from a chronically infected patient with CVID as well as from cases of acute enterovirus infection. Phylogenetic analysis showed that E... |
The European Cystic Fibrosis Society Patient Registry: valuable lessons learned on how to sustain a disease registry
Background: Disease registries have the invaluable potential to provide an insight into the natural history of the disease under investigation, to provide useful information (e.g. through health indicat... |
Extragenital lichen sclerosus et atrophicus within a skin graft scar
# Introduction
Lichen sclerosus et atrophicus (LSA) is rare chronic relapsing skin condition typically arising in postmenopausal women and prepubescent children in the genital area. Only 6% of cases occur in extragenital skin without concomitant an... |
Primary and secondary dystonic syndromes: an update
Purpose of reviewThe dystonias are a common but complex group of disorders that show considerable variation in cause and clinical presentation. The purpose of this review is to highlight the most important discoveries and insights from across the field over the perio... |
Health-related quality of life after gastric cancer treatment in Brazil: Narrative review and reflections
# Introduction
Most gastric adenocarcinomas affect men approximately 60-70 years of age. Approximately 65% of patients are over 50 years old. Gastric cancer is the third most common type of cancer among men and ... |
The EROP-Moscow oligopeptide database
Natural oligopeptides may regulate nearly all vital processes. To date, the chemical structures of nearly 6000 oligopeptides have been identified from .1000 organisms representing all the biological kingdoms. We have compiled the known physical, chemical and biological properties ... |
Infectious Complications in Home Parenteral Nutrition: A Systematic Review and Meta-Analysis Comparing Peripherally-Inserted Central Catheters with Other Central Catheters
## Question 1. described as randomized
Was the study described as randomized? A study does not satisfy quality criteria as randomized simply beca... |
Pitch and Timbre Interfere When Both Are Parametrically Varied
Pitch and timbre perception are both based on the frequency content of sound, but previous perceptual experiments have disagreed about whether these two dimensions are processed independently from each other. We tested the interaction of pitch and timbre v... |
Promoter- and cell-specific epigenetic regulation of CD44, Cyclin D2, GLIPR1 and PTEN by Methyl-CpG binding proteins and histone modifications
Background :The aim of the current study was to analyze the involvement of methyl-CpG binding proteins (MBDs) and histone modifications on the regulation of CD44, Cyclin D2, GL... |
Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo
Primary infection with virus can stimulate a vigorous cytotoxic T cell response. The magnitude of the antigen-specific component versus the bystander component of a primary T cell response remains cont... |
Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line
Humans use a family of more than 400 olfactory receptors (ORs) to detect odorants. However, deorphanization of ORs is a critical issue because the functional properties of more than 80% of ORs remain unknown, thus, hamper... |
A meta-analysis comparing stereotactic body radiotherapy vs conventional radiotherapy in inoperable stage I non-small cell lung cancer
Background: Stereotactic body radiotherapy (SBRT) superseded conventional radiotherapy (CRT) for the treatment of patients with inoperable early stage non-small cell lung cancer (NSCLC... |
Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
[bib_ref] Aging and health -a systems biology perspective. introduction, Jazwinski [/bib_ref] [bib_ref] Complex systems dynamics in aging: new evidence, continuing questions, Cohen [/bib_ref] [bib_ref] Does the human immune system ever... |
The Evolution of Polycentric Governance in the Galapagos Small-Scale Fishing Sector
Addressing the multiple anthropogenic and non-anthropogenic factors affecting small-scale fisheries requires collaboration from diverse regions, geographical scales, and administrative levels in order to prevent a potential misfit betw... |
Structural and functional neural adaptations in obstructive sleep apnea: An activation likelihood estimation meta-analysis
a b s t r a c tObstructive sleep apnea (OSA) is a common multisystem chronic disorder. Functional and structural neuroimaging has been widely applied in patients with OSA, but these studies have o... |
Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation
ACER2 is a critical sphingolipid metabolizing enzyme, and has been shown to be remarkably upregulated following various stimuli such as DNA damage. However, the transcriptional regulatory mechanism of ACER2... |
Actual Anatomical and Dosimetric Changes of Parotid Glands in Nasopharyngeal Carcinoma Patients during Intensity Modulated Radiation Therapy
The goal of this study was to evaluate the actual anatomical and dosimetric changes of parotid glands in nasopharyngeal carcinoma patients during intensity modulated radiation th... |
Clinical Outcomes of In-office Sutureless Amniotic Membrane Transplantation in Persistent Epithelial Defect
Purpose: To investigate the efficacy of outpatient clinic-based sutureless amniotic membrane transplantation (AMT) along with therapeutic contact lens (T-lens) application in eyes with persistent epithelial defe... |
Review of Laser Raman Spectroscopy for Surgical Breast Cancer Detection: Stochastic Backpropagation Neural Networks
Laser Raman spectroscopy (LRS) is a highly specific biomolecular technique which has been shown to have the ability to distinguish malignant and normal breast tissue. This paper discusses significant adv... |
High Rates of Three Common GJB2 Mutations c.516G>C, c.-23+1G>A, c.235delC in Deaf Patients from Southern Siberia Are Due to the Founder Effect
The mutations in the GJB2 gene (13q12.11, MIM 121011) encoding transmembrane protein connexin 26 (Cx26) account for a significant portion of hereditary hearing loss worldwide. ... |
Managing bevacizumab-induced intraocular inflammation
The outcome of four cases of sterile endophthalmitis that developed after intravitreal injections of bevacizumab has been reported here. All four eyes received 1.25 mg/0.05 ml intravitreal bevacizumab from 0.2-ml aliquots for different etiologies. The inflammation ... |
Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis
This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors.Supplement to: Huhn M,... |
Spontaneous Gastric Perforation in a Case of Collagenous Gastritis
Collagenous gastritis is an extremely rare disease, both in children and adults. Symptoms vary depending on the extent of collagenous changes in the bowel. In most of the children, iron deficiency anemia and abdominal pain are the presenting symptoms. ... |
Near-Infrared Plasmonic Assemblies of Gold Nanoparticles with Multimodal Function for Targeted Cancer Theragnosis
Here we report a novel assembly structure of near-infrared plasmonic gold nanoparticles (AuNPs), possessing both photoacoustic (PA) and photothermal (PT) properties. The template for the plasmonic AuNP ass... |
Co-Selection of Resistance to Antibiotics, Biocides and Heavy Metals, and Its Relevance to Foodborne Pathogens
Concerns have been raised
# Introduction
Biocides, in the broadest sense, are substances formulated to be harmful to (or to otherwise control) living organisms [bib_ref] Assessment of the Antibiotic Resistan... |
Lost but not forgotten: A population‐based study of mortality and care trajectories among people living with HIV who are lost to follow‐up in Ontario, Canada
ObjectivesSelection as a consequence of volunteer participation in, and loss to follow-up from, cohort studies may bias estimates of mortality and other health o... |
Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1
Background: Human immunodeficiency virus type 1 (HIV-1) uses cellular proteins and machinery to ensure transmission to uninfected cells. Although the host proteins involved in the transport of viral components t... |
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