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Illuminating novel biological aspects and potential new therapeutic approaches for chronic myeloproliferative malignancies
This review reflects the presentations and discussion at the 14th post-American Society of Hematology (ASH) International Workshop on Chronic Myeloproliferative Malignancies, which took place on t... |
Utility of Transcranial Magnetic Simulation in Studying Upper Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis
Citation: Geevasinga, N.; Van den Bos, M.; Menon, P.; Vucic, S. Utility of Transcranial Magnetic Simulation in Studying Upper Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis. Brain Sci. 202... |
Influence of polymer size, liposomal composition, surface charge, and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid)
Background: Liposomes containing pH-sensitive polymers are promising candidates for the treatment of tumors and localized infection. This s... |
Models of turfgrass seed germination related to water content
Turfgrasses have been widely utilized by humans to enhance the environment for more than several centuries. Seed germination is of great importance in the development of the turfgrass industry. In this study, the seed germination models of the responses of ... |
LncRNA MALAT1 functions as a biomarker of no-reflow phenomenon in ST-segment elevation myocardial infarction patients receiving primary percutaneous coronary intervention
MALAT1 was reported to sponge miR-30e, miR-126 and miR-155 in the pathogenesis of many diseases. Plasma miR-30e can indicate the risk of no-reflow d... |
A pulse of mid-Pleistocene rift volcanism in Ethiopia at the dawn of modern humans
LNE and 31-01-LE are 3shown. Ages shown are the weighted mean ± standard error of the mean (1σ), and in brackets 4 the arithmetic mean ± one standard deviation. While both methods of error reporting are 5 equally valid, for consistency ... |
Coexistence of granuloma annulare and chronic spontaneous urticaria*
[bib_ref] Etiology, diagnosis, and therapeutic management of granuloma annulare: an update, Thornsberry [/bib_ref] [bib_ref] Interstitial type granuloma annulare associated with Sjögren's syndrome, Sumikawa [/bib_ref] [fig_ref] Figure 1: Annular ery... |
Multilayer Dye Aggregation at Dye/TiO2 Interface via π…π Stacking and Hydrogen Bond and Its Impact on Solar Cell Performance: A DFT Analysis
Multilayer dye aggregation at the dye/TiO 2 interface of dye-sensitized solar cells is probed via firstprinciples calculations, using p-methyl red azo dye as an example. Our calc... |
Firearm bullet settling into the lumbar spinal canal without causing neurological deficit: A report of two cases
Background: Uncertainty still exists regarding the treatment of the patients presenting with gunshot wounds to the spine. Neurological insults, cerebrospinal fluid fistula, infection, lead or copper toxicit... |
Participatory Development and Analysis of a Fuzzy Cognitive Map of the Establishment of a Bio-Based Economy in the Humber Region
Fuzzy Cognitive Mapping (FCM) is a widely used participatory modelling methodology in which stakeholders collaboratively develop a 'cognitive map' (a weighted, directed graph), representing ... |
Chronotherapy for morning blood pressure surge in hypertensive patients: a systematic review and meta-analysis
Background:The morning blood pressure surge (MBPS) is related to an exaggerated risk of cardiovascular diseases and mortality. With increasing attention on circadian change in blood pressure and extensive use... |
Elements of Psychological Medicine; an Introduction to the Practical Study of Insanity, Adapted for Students and Junior Practitioners
Medical Officer to the Clifton Hall Retreat, &c
M.DMedical Officer to the Clifton Hall Retreat, &c
181 Review XII.
Medicine, in Manchester, and which he has published at the request of ... |
Physical activity and the prevention, reduction, and treatment of alcohol and/or substance use across the lifespan (The PHASE review): protocol for a systematic review
Background: Alcohol and substance use results in significant human and economic cost globally and is associated with economic costs of £21 billion and ... |
Identification of QTNs and Their Candidate Genes for 100-Seed Weight in Soybean (Glycine max L.) Using Multi-Locus Genome-Wide Association Studies
100-seed weight (100-SW) in soybeans is a yield component trait and controlled by multiple genes with different effects, but limited information is available for its quanti... |
Hepatobiliary case report and literature review of hepatic reactive lymphoid hyperplasia with positive anti-smooth muscle antibody and anti-nuclear antibody tests
Hepatic reactive lymphoid hyperplasia (RLH) is a rare benign tumor of the liver that exhibits similar imaging characteristics to those of other hepatic mali... |
Postoperative radiotherapy is effective in improving survival of patients with stage pIII-N2 non-small-cell lung Cancer after pneumonectomy
Background: There were few reports of postoperative radiotherapy (PORT) in stage pIII-N2 Non-small-cell Lung Cancer (NSCLC) patients receiving pneumonectomy followed by adjuvant c... |
Identification of benign and malignant thyroid nodules by in vivo iodine concentration measurement using single-source dual energy CT
This study proposed to determine whether in vivo iodine concentration measurement by single-source dual energy (SSDE) CT can improve differentiation between benign and malignant thyroid... |
Design and Implementation of a Distant-Learning Clinical Research Mentorship Program: The Accra-Toronto Collaboration
PURPOSE For many oncology training programs in low-and middle-income countries, dedicated time for research education and mentorship of trainees is limited. Here, we report a 1-year-long collaboration ... |
Hemorrhagic Bullous Henoch-Schönlein Purpura: Case Report and Review of the Literature
Henoch-Schönlein Purpura (HSP) or IgA vasculitis is the most common systemic vasculitis of childhood and may affect skin, joints, gastrointestinal tract, and kidneys. Skin manifestations of HSP are characteristic and include a non-t... |
Doctor Referral of Overweight People to Low Energy total diet replacement Treatment (DROPLET): pragmatic randomised controlled trial
[bib_ref] From quantum dynamics to the canonical distribution: general picture and rigorous example, Tasaki [/bib_ref] [bib_ref] Entanglement and the foundations of statistical mechanic... |
Patterns of care for older patients with stage IV non‐small cell lung cancer in the immunotherapy era
Background:Historically, older patients with advanced lung cancer have often received no systemic treatment. Immunotherapy has improved outcomes in clinical trials, but its dissemination and implementation at the popu... |
A MT-TL1 variant identified by whole exome sequencing in an individual with intellectual disability, epilepsy, and spastic tetraparesis
The genetic etiology of intellectual disability remains elusive in almost half of all affected individuals. Within the Solve-RD consortium, systematic re-analysis of whole exome seque... |
Bilateral Mandibular Condylar Fractures with Associated External Auditory Canal Fractures and Otorrhagia
Case reportA 19-year-old female fell 20 feet from a roof and presented with a complete laceration of the lower lip and bilateral otorrhagia. A maxillofacial computed tomography (CT) exam(Fig. 1) revealed a nondispl... |
Application of inulin in bread: A review of technological properties and factors affecting its stability
Due to its dual function, inulin is an important prebiotic compound in the cereal industry, especially in bread production. In other words, improving technological features and creating health properties (such as r... |
Current data and strategy in glioblastoma multiforme
Glioblastoma multiforme (GBM) or astrocytoma grade IV on WHO classification is the most aggressive and the most frequent of all primary brain tumors. Glioblastoma is multiforme, resistant to therapeutic interventions illustrating the heterogeneity exhibited by this ... |
Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death
The tumor cell-selective killing activity of the adenovirus type 2 early region 4 ORF4 (E4orf4) protein is poorly defined at the molecular level. Here, we show that the tumoricidal effect of E4orf4 is typi... |
Estimating the cost of referral and willingness to pay for referral to higher-level health facilities: a case series study from an integrated community case management programme in Uganda
Background: Integrated community case management (iCCM) relies on community health workers (CHWs) managing children with malaria, p... |
Epsilon wave disappearance by catheter ablation for ventricular arrhythmia from the left ventricular outflow tract
# Introduction
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is pathologically characterized by fibrofatty replacements. [bib_ref] Arrhythmogenic right ventricular cardiomyopathy, Basso [/bib_r... |
Applying a Yin–Yang Perspective to the Theory of Paradox: A Review of Chinese Management
This paper examines the paradox in management through the yin-yang lens and how to apply the yin-yang perspective in Chinese indigenous management research through a literature review. Compared with several western philosophical p... |
A Case of Recurrent Vogt-Koyanagi-Harada Disease Successfully Treated with Adalimumab in Young Female Adult Patient
## A case of recurrent vogt-koyanagi-harada disease successfully treated with adalimumab in young female adult patient
Dear Editor, Vogt-Koyanagi-Harada (VKH) disease is characterized by diffuse, bilat... |
Determinants of quality of shared sanitation facilities in informal settlements: case study of Kisumu, Kenya
Background: Shared facilities are not recognised as improved sanitation due to challenges of maintenance as they easily can be avenues for the spread of diseases. Thus there is need to evaluate the quality of s... |
Simultaneous assessment of cell morphology and adhesion using aluminum nanoslit-based plasmonic biosensing chips
A variety of physiological and pathological processes rely on cell adhesion, which is most often tracked by changes in cellular morphology. We previously reported a novel gold nanoslit-based biosensor that ... |
Prospective multicentre cross-sectional audit among older Australians accessing health and residential aged care services: protocol for a national advance care directive prevalence study
# Introduction background
Advance care planning (ACP) is a coordinated communication and planning process that aims to clarify and... |
Idiopathic small bowel diaphragm disease: a case report
Small bowel diaphragm disease is a rare condition usually associated with the prolonged use of non-steroidal antiinf lammatory drugs (NSAID) and that can be mistaken and treated as other pathologies. We describe a case of a 64-year-old man with a prolonged course... |
Stress, physical activity, and screen‐related sedentary behaviour within the first month of the COVID‐19 pandemic
This study investigated how stress, physical activity and sedentary behaviours, of a small sample of Canadians, changed within the first month (i.e. March/April) of the COVID-19 pandemic and the reasons/ba... |
Flow Cytometric Diagnosis of Paroxysmal Nocturnal Hemoglobinuria: Pearls and Pitfalls – A Critical Review Article
A R T I C L E I N F O A B S T R A C TParoxysmal Nocturnal Hemoglobinuria (PNH) is a rare blood disorder characterized by chronic intravascular hemolysis, thromboses in unusual sites and cytopenias related ... |
Overweight and Obesity Among Chinese College Students: An Exploration of Gender as Related to External Environmental Influences
[bib_ref] Physical activity, food choice, and weight management goals and practices among U.S...., Lowry [/bib_ref] [bib_ref] College weight gain and behavior transitions: Male and female di... |
A method for independent component graph analysis of resting‐state fMRI
A method for independent component graph analysis of resting-statefMRI DemetriusRibeirodePaula 1 | ErikZiegler 2 | PubudithaM.Abeyasinghe 1 | TusharK.Das 1 | Carlo Cavaliere 2,3 | MarcoAiello 3 | LizetteHeine 2 | CaroldiPerri 2 | AthenaDemertzi 2,... |
Tracheal tube misplacement in the thoracic cavity: A case report
BACKGROUNDPenetrating neck injuries require prompt recognition, diagnosis and management of critical airways. This case demonstrates an emergent situation that a "medical negligence" was avoided with the aid of end-tidal carbon dioxide (ETCO 2 ) waveform... |
Sexual and Reproductive Health Problems of Female University Students in Iran: A Qualitative Study
Objective: Youth is defined as the time of transition into adulthood and an important period in a person's life. During this period new behavior is learned easier than adulthood. Therefore, special attention has to be ne... |
Copper-based fluorinated reagents for the synthesis of CF2R-containing molecules (R ≠ F)
Over the years, the development of new methodologies for the introduction of various fluorinated motifs has gained a significant interest due to the importance of fluorine-containing molecules in the pharmaceutical and agrochemica... |
Pharmacokinetic interactions and tolerability of rosuvastatin and ezetimibe: an open-label, randomized, multiple-dose, crossover study in healthy male volunteers
# Introduction
Globally, cardiovascular disease (CAD) is a major cause of morbidity and death. Dyslipidemia, hypertension, diabetes mellitus (DM), and obes... |
Dynamics of the excised base release in thymine DNA glycosylase during DNA repair process
Thymine DNA glycosylase (TDG) initiates base excision repair by cleaving the N-glycosidic bond between the sugar and target base. After catalysis, the release of excised base is a requisite step to terminate the catalytic cycle a... |
Effect of Metoprolol Succinate in Patients with Stable Angina and Elevated Heart Rate Receiving Low-Dose β-Blocker Therapy
Aims: β-blockers are underused in Chinese patients with coronary heart disease. The prescribed dose is often low. The aim of this study was to investigate the effect of metoprolol succinate doses ... |
Role of Polar Phonons in the Photo Excited State of Metal Halide Perovskites
The exciton binding energies presented in the paper have been calculated using 'semi-cubic' unit cells. These structures have been obtained by allowing all atoms to relax (keeping the experimental lattice shape and volume fixed) using damped ... |
Correlation between initial tumour volume and treatment duration on Dabrafenib: observation study of subjects with BRAF mutant melanoma on the BRF112680 trial
Background: Planar-based measurements of lesions in metastatic melanoma have limitations in estimating tumor burden of a patient and in predicting response to t... |
A Randomized Double-Blind, Placebo-Controlled Study on Anti-Stress Effects of Nelumbinis Semen
Citation: Ye, M.; Bae, H.; Park, S.; Lew, J.; Kim, K.S.; Shim, I. A Randomized Double-Blind, Placebo-Controlled Study on Anti-Stress Effects of Nelumbinis Semen. Int.
# Introduction
Depression is a common mood disease chara... |
The breast cancer somatic 'muta-ome': tackling the complexity
ER = estrogen receptor; GI = genomic instability; HD = homozygous deletion; SNP = single-nucleotide polymorphism.
Acquired somatic mutations are responsible for approximately 90% of breast tumours. However, only one somatic aberration, amplification of the ... |
Examining the readiness of best evidence in medical education guides for integration into educational practice: A meta-synthesis
Background To support evidence-informed education, health professions education (HPE) stakeholders encourage the creation and use of knowledge syntheses or reviews. However, it is unclear if... |
Xtrapol8 enables automatic elucidation of low-occupancy intermediate-states in crystallographic studies
Unstable states studied in kinetic, time-resolved and ligand-based crystallography are often characterized by a low occupancy, which hinders structure determination by conventional methods. To automatically extract ... |
Stuck in the middle: a systematic review of authorship in collaborative health research in Africa, 2014–2016
[bib_ref] The characteristics of highly cited researchers in, Confraria [/bib_ref] [bib_ref] Authorship trends in the Lancet global health, Iyer [/bib_ref]
# Introduction
Despite increases in African researc... |
Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review
Introduction: As a result of the increased use of radiotherapy (RT) and improved long-term overall survival of patients with cancers of the head and neck (HN), the frequency of radiationinduced sarcomas of the head and neck (RISHN) may be increasing.... |
A member of the Whirly family is a multifunctional RNA- and DNA-binding protein that is essential for chloroplast biogenesis
Whirly' proteins comprise a plant-specific protein family whose members have been described as DNA-binding proteins that influence nuclear transcription and telomere maintenance, and that associ... |
A case of recalcitrant silicone granuloma treated with adalimumab: A case report
Liquid silicone is a relatively inexpensive injectable used for soft tissue augmentation. Injection of silicone is associated with a risk of delayed granuloma formation associated with elevated levels of tumour necrosis factor-α. We repor... |
Online community engagement in response to COVID‐19 pandemic
| 729LETTER TO THE EDITOR were used to mitigate these issues. We recognize that community engagement is difficult during crises due to changing lifestyles and commitments with some CFs volunteering to deliver necessities in their community. Whilst not observ... |
Systemic Immunosuppression in High-Risk Penetrating Keratoplasty: A Systematic Review
Cornea transplantation has a high success rate and typically only requires topical immunomodulation. However, in high-risk cases, systemic immunosuppression can be used. We conducted a systematic review on the efficacy and side effec... |
Point-of-Care Virologic Testing to Improve Outcomes of HIV-Infected Children in Zambia: A Clinical Trial Protocol
# Introduction
Despite recent advances in prevention science, pediatric AIDS remains an important public health problem in many countries with high HIV burden. In 2014, an estimated 170,000 children were... |
Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
# Introduction
Recent developments in nanotechnology have enabled new research strategies to flourish in the field of drug delivery. There has been considerable interest in developing nanoparticles as effective drug carriers. [bib_re... |
Disposal of iNKT cell deficiency and an increase in expression of SLAM signaling factors characterizes sarcoidosis remission: a 4-year longitudinal study
Background: Invariant NKT (iNKT) cells are regulatory lymphocytes that may be important in disorders with increased Th1 responses. We utilized a 4-year longitudinal ... |
High prevalence of unawareness of HCV infection status among both HCV-seronegative and seropositive people living with human immunodeficiency virus in Taiwan
ObjectivesHCV infection status awareness is crucial in the HCV care continuum for both HCV-seropositive (HCV-positive status awareness) and seronegative (HCV-neg... |
Timing of Histologic Progression from Chorio-Deciduitis to Chorio-Deciduo-Amnionitis in the Setting of Preterm Labor and Preterm Premature Rupture of Membranes with Sterile Amniotic Fluid
BackgroundHistologic chorio-deciduitis and chorio-deciduo-amnionitis (amnionitis) in extra-placental membranes are known to represe... |
Increasing secular trends in height and obesity in children with type 1 diabetes: JSGIT cohort
BackgroundRecently, anthropometric indices in children with type 1 diabetes mellitus (T1DM) have begun to change.ObjectiveTo examine secular trends in patients' anthropometric indices.SubjectsJapanese children with T1DM from... |
The Inhaler Technique Questionnaire (InTeQ): Development and Validation of a Brief Patient-Reported Measure
Citation: Lizano-Barrantes, C.; Garin, O.; Dima, A.L.; van Ganse, E.; de Bruin, M.; Belhassen, M.; Mayoral, K.; Pont, À.; Ferrer, M. The Inhaler Technique Questionnaire (InTeQ): Development and Validation of a B... |
Prediction of organic homolytic bond dissociation enthalpies at near chemical accuracy with sub-second computational cost
Bond dissociation enthalpies (BDEs) of organic molecules play a fundamental role in determining chemical reactivity and selectivity. However, BDE computations at sufficiently high levels of quantum... |
Evaluating changes in the prevalence of female genital mutilation/cutting among 0-14 years old girls in Nigeria using data from multiple surveys: A novel Bayesian hierarchical spatio-temporal model
Female genital mutilation/cutting (FGM/C) is considered a public health and human rights concern, mainly concentrated in ... |
Exopolysaccharides produced by marine bacteria and their applications as glycosaminoglycan-like molecules
Although polysaccharides are ubiquitous and the most abundant renewable bio-components, their studies, covered by the glycochemistry and glycobiology fields, remain a challenge due to their high molecular diversit... |
A case report of nonepisodic angioedema with eosinophilia in a Korean patient and a review of the Korean literature
Episodic angioedema with eosinophilia (EAE) is characterized by recurrent angioedema, peripheral eosinophilia, elevated serum IgM, fever, weight gain, and a benign course lacking any internal organ invol... |
Alemtuzumab in Multiple Sclerosis: Short- and Long-Term Effects of Immunodepletion on the Peripheral Treg Compartment
Treatment with alemtuzumab is followed by an early increase in Treg frequencies.Whether naïve and memory subsets are differentially affected and how depletion influences dysfunctional MS-Treg is unclea... |
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer mortality. Although advances have been made in understanding the pathogenesis of PDAC, the outcome still remains poor. The aim of this study is to conduct a metaanalysis to evaluate the precise association between SMAD4 loss and clinicopatho... |
Prevalence of HCV NS3 pre-treatment resistance associated amino acid variants within a Scottish cohort
a b s t r a c tBackground: Protease inhibitors (PI) including boceprevir, telaprevir and simeprevir have revolutionised HCV genotype 1 treatment since their introduction. A number of pre-treatment resistance associat... |
An improved method for the isolation and identification of unknown proteins that bind to known DNA sequences by affinity capture and mass spectrometry
Transcription of a gene can be regulated at many different levels. One such fundamental level is interaction between protein and DNA. Protein(s) binds to distinct sites... |
## Supplementary
## Removal efficiency re(d bc )
[formula] D BC4 D BC5 D BC3 D BC1 D BC2 D BC3 D BC4 D BC5 [/formula]
BC-containing particle BC-free particle
[formula] Amount of non-BC coating R D BC -resolved num. conc. N air (D BC ) D BC -resolved num. conc. N rain (D BC ) [/formula]
Hygroscopicity of non-BC mater... |
Delayed Onset of Pleural Effusion After Thoracic Radiation Therapy for Hodgkin Lymphoma: A Case Report With Over 30-Year Follow-Up
Pleural effusion after thoracic radiation therapy is an important adverse event affecting the patient's quality of life. A 58-year-old woman was referred to our hospital with the complaint... |
Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly emergent tick-borne bunyavirus first discovered in 2009 in China. SFTSV is a growing public health problem that may become mor... |
IgM Augments Complement Bactericidal Activity with Serum from a Patient with a Novel CD79a Mutation
Antibody replacement therapy for patients with antibody deficiencies contains only IgG. As a result, concurrent IgM and IgA deficiency present in a large proportion of antibody deficient patients persists. Especially pa... |
Nitric oxide and mitochondria in metabolic syndrome
Metabolic syndrome (MS) is a cluster of metabolic disorders that collectively increase the risk of cardiovascular disease. Nitric oxide (NO) plays a crucial role in the pathogeneses of MS components and is involved in different mitochondrial signaling pathways that c... |
A review of the therapeutic role of the new third-generation TKI olverembatinib in chronic myeloid leukemia
Several tyrosine kinase inhibitors (TKIs) have been developed as targeted therapies to inhibit the oncogenic activity of several tyrosine kinases in chronic myeloid leukemia (CML), acute lymphoid leukemia (ALL),... |
Ataxia-telangiectasia mutated (ATM) gene mutation in a patient with primary cutaneous marginal zone lymphoma
# Introduction
Primary cutaneous marginal B-cell lymphoma (PCMZL), a type of extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue, is a common indolent non-Hodgkin lymphoma that typica... |
The role of long non-coding RNAs in cardiac development and disease
Cells display a set of RNA molecules at one time point, reflecting thus the cellular transcriptional steady state, configuring therefore its transcriptome. It is basically composed of two different classes of RNA molecules; protein-coding RNAs (cRNAs)... |
ycf1, the most promising plastid DNA barcode of land plants
A DNA barcode is a DNA fragment used to identify species. For land plants, DNA fragments of plastid genome could be the primary consideration. Unfortunately, most of the plastid candidate barcodes lack species-level resolution. The identification of DNA barco... |
Detecting Transforming Growth Factor-β Release from Liver Cells Using an Aptasensor Integrated with Microfluidics
We developed a cell-culture/biosensor platform consisting of aptamer-modified Au electrodes integrated with reconfigurable microfluidics for monitoring of transforming growth factor-beta 1 (TGF-β1), an imp... |
Long-term effects and costs of pelvic floor muscle training for prolapse: trial follow-up record-linkage study
Introduction and hypothesis Pelvic organ prolapse affects around 40% of women aged over 50 years. A multicentre parallel group randomised trial (the Pelvic Organ Prolapse PhysiotherapY (POPPY) trial) demonstr... |
A Retrospective Comparison of Ultrasound-Assisted Catheter-Directed Thrombolysis and Catheter-Directed Thrombolysis Alone for Treatment of Proximal Deep Vein Thrombosis
Background Recent studies have suggested that catheterdirected thrombolysis (CDT) reduces development of postthrombotic syndrome (PTS). Ultrasound-ass... |
Fever as a first presentation of castration-resistant prostate cancer: A case report
Rationale: Cancer is a well-recognized cause of fever, which is related to cytokines produced by malignant cells. Prostate cancer presenting with fever and other inflammatory markers as a paraneoplastic syndrome rarely occurs.Patients... |
A comprehensive review of the progress of cell migration inducing hyaluronidase 1
The gene cell migration inducing hyaluronidase 1 (CEMIP) is on chromosome 15q25 and codes for a 150-kDa protein with an N-terminal secretion signal, a G8 domain, 2 GG domains, and several repeats. It was first described as a specific pro... |
PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208
Colorectal cancer (CRC) is the third most common cancer worldwide. The standard treatment in locally advanced rectal cancer is preoperative radiation alone or in combination with chemotherapy, foll... |
ICU Pad Project: application of modern computer technology in pediatric postoperative cardiac intensive care. Pilot study
## Quality in medicine
After cardiac surgery procedures, all vital functions of the patient must be monitored carefully with particular focus on hemodynamic parameters. Optimizing the function o... |
Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance
Background: Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival. The last three decades has witnessed a change ... |
Increasing physical activity levels following treatment for cervical cancer: an intervention mapping approach
Purpose The purpose of this study was to utilise the intervention mapping (IM) protocol as a framework with which to develop an intervention underpinned by relevant behaviour change theory to promote physical ... |
Third Line Eribulin for Triple-negative Metastatic Breast Ductal Carcinoma Resulting in Extended Progression-free Survival of 57 Months
# Introduction
Triple-negative breast cancer (TNBC) is a term that has been applied to breast cancers that lack expression of the estrogen receptor (ER), progesterone receptor (PR),... |
Feeding Difficulty in an Infant with Stickler‘s Syndrome
Stickler syndrome or hereditary progressive arthro-ophthalmopathy is an autosomal dominant condition characterized by ocular manifestations, arthritic changes, orofacial features, and deafness, in variable degrees. This is a case report of a 48-day-old infant wh... |
Identifying clusters of leprosy patients in India: A comparison of methods
BackgroundPreventive interventions with post-exposure prophylaxis (PEP) are needed in leprosy highendemic areas to interrupt the transmission of Mycobacterium leprae. Program managers intend to use Geographic Information Systems (GIS) to target... |
The Spatial Differentiation and Driving Forces of Ecological Welfare Performance in the Yangtze River Economic Belt
Ecological welfare performance contributes directly to human well-being and regional sustainable development. Improving the regional ecological welfare performance in the process of pursuing green and su... |
Applications of water molecules for analysis of macromolecule properties
a b s t r a c tWater molecules maintain proteins' structures, functions, stabilities and dynamics. They can occupy certain positions or pass quickly via a protein's interior. Regardless of their behaviour, water molecules can be used for the anal... |
Interactions between Microbial Food Safety and Environmental Sustainability in the Fresh Produce Supply Chain
# Introduction
Fresh produce is being increasingly recognized as a source of foodborne outbreaks. The burden of such outbreaks includes economic losses, healthcare costs, loss of productivity, reductions in ... |
The beginning and the end of SNARE‐induced membrane fusion
Membrane fusion is not a spontaneous process. Physiologically, the formation of coiled-coil protein complexes, the SNAREpins, bridges the membrane of a vesicle and a target membrane, brings them in close contact, and provides the energy necessary for their fus... |
The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study
ObjectiveTo study the involvement of the anterior nuclei of the thalamus (ANT) as compared to the involvement of the hippocampus in the processes of encoding and recognition during visual and verbal m... |
Association of Use of Omega-3 Polyunsaturated Fatty Acids With Changes in Severity of Anxiety Symptoms
et al. Association of use of omega-3 polyunsaturated fatty acids with changes in severity of anxiety symptoms: a systematic review and meta-analysis. JAMA Netw Open.
[fig] 21: Hakimian J, Minasyan A, Zhe-Ying L, et a... |
Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells
In non-small cell lung carcinoma (NSCLC), stimulation of toll-like receptor 7 (TLR7), a receptor for single stranded RNA, is linked to tumor progression and resistance... |
Strategies for Interfering With Bacterial Early Stage Biofilms
Biofilm-related bacteria show high resistance to antimicrobial treatments, posing a remarkable challenge to human health. Given bacterial dormancy and high expression of efflux pumps, persistent infections caused by mature biofilms are not easy to treat, t... |
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