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The stage analysis and countermeasures of coal spontaneous combustion based on “five stages” division
The "three stages" division of coal spontaneous combustion is fuzzy and lacks adequate risk and warning levels corresponding to its divisions; additionally, the targeted prevention measures for each stage have not bee... |
Exploring the Public Health of Travel Behaviors in High-Speed Railway Environment during the COVID-19 Pandemic from the Perspective of Trip Chain: A Case Study of Beijing–Tianjin–Hebei Urban Agglomeration, China
The outbreak and spreading of COVID-19 since early 2020 have dramatically impacted public health and the tr... |
Genome-wide classification and expression analysis of MYB transcription factor families in rice and Arabidopsis
Background:The MYB gene family comprises one of the richest groups of transcription factors in plants. Plant MYB proteins are characterized by a highly conserved MYB DNA-binding domain. MYB proteins are clas... |
The Metabotropic Purinergic P2Y Receptor Family as Novel Drug Target in Epilepsy
Epilepsy encompasses a heterogeneous group of neurological syndromes which are characterized by recurrent seizures affecting over 60 million people worldwide. Current anti-epileptic drugs (AEDs) are mainly designed to target ion channels ... |
Bedside EEG predicts longitudinal behavioural changes in disorders of consciousness
A B S T R A C TProviding an accurate prognosis for prolonged disorder of consciousness (pDOC) patients remains a clinical challenge. Large cross-sectional studies have demonstrated the diagnostic and prognostic value of functional brai... |
Health and Economic Burden of Post-Partum Staphylococcus aureus Breast Abscess
Objectives: To determine the health and economic burdens of post-partum Staphylococcus aureus breast abscess.Study design: We conducted a matched cohort study (N = 216) in a population of pregnant women (N = 32,770) who delivered at our cen... |
Untargeted LC-MS Metabolomics Differentiates Between Virulent and Avirulent Clinical Strains of Pseudomonas aeruginosa
[formula] CH2690.A CH2690.B CH2690.C ESP058.A ESP058.B ESP058.C ESP067.A ESP067.B ESP067.C F1997.A F1997.B F1997.C MHH17704.A MHH17704.B MHH17704.C Psae1439.A Psae1439.B Psae1439.C ZG8038581181.A ZG... |
Predictors of competing mortality to invasive breast cancer incidence in the Canadian National Breast Screening study
Background: Evaluating the cost-effectiveness of breast cancer screening requires estimates of the absolute risk of breast cancer, which is modified by various risk factors. Breast cancer incidence, an... |
Transcriptomic Analysis of Carboxylic Acid Challenge in Escherichia coli: Beyond Membrane Damage
Carboxylic acids are an attractive biorenewable chemical. Enormous progress has been made in engineering microbes for production of these compounds though titers remain lower than desired. Here we used transcriptome analys... |
Emotional intelligence of nurses caring for COVID-19 patients: A cross-sectional study
# Introduction
World health organization declared the COVID-19 crisis as a pandemic with a public health emergency [bib_ref] COVID-19: Emerging compassion, courage and resilience in the face of misinformation and..., Smith [/bib_r... |
Disseminated tumour cells as a prognostic biomarker in colorectal cancer
BACKGROUND: The study was performed to determine detection rate and prognostic relevance of disseminated tumour cells (DTC) in patients receiving curatively intended surgery for colorectal cancer (CRC). METHODS: The study population consisted of ... |
Metastatic HPV‐related oropharyngeal carcinoma cured with chemoradiotherapy: importance of pretherapy biomolecular assessment
Pretherapy assessment has a crucial role in the management of advanced oropharyngeal carcinoma. The case report represents an example of how translational research may help to optimize the ther... |
A Case Report of Lifesaving Intravenous Bolus Epinephrine Administration in a Case of Severe Refractory Anaphylactic Shock
# Introduction
Anaphylaxis is an acute hypersensitivity reaction to a stimulus that can be life-threatening if early measures are not taken promptly [bib_ref] The epidemiology of anaphylaxis, Yu... |
In Vitro Characterization of Poly(Lactic Acid)/ Poly(Hydroxybutyrate)/ Thermoplastic Starch Blends for Tissue Engineering Application
Complex in vitro characterization of a blended material based on Poly(Lactic Acid), Poly(Hydroxybutyrate), and Thermoplastic Starch (PLA/PHB/TPS) was performed in order to evaluate its ... |
Marginal bone loss 1 year after implantation: a systematic review for fixed and removable restorations
This systematic review analyses the difference of the mean marginal bone loss (MBL) 1 year after implantation depending on the fixation of the restoration. 889 publications on controlled clinical trials were identifi... |
The short and long-term effects of aerobic, strength, or mixed exercise programs on schizophrenia symptomatology
The purpose of this study was to compare the effects of three different physical exercise programs on the symptomatology, body composition, physical activity, physical fitness, and quality of life of indivi... |
Lost in translation—the use of remote and on-animal sensing for extensive livestock systems
# Introduction
Remote and on-animal sensors underpin the development of Precision Livestock Farming (PLF). These technologies have been demonstrated in intensive livestock production resulting in decreased labor costs and in ... |
Renal Hypoxia in CKD; Pathophysiology and Detecting Methods
Chronic kidney disease (CKD) is a major public health problem. Accumulating evidence suggests that CKD aggravates renal hypoxia, and in turn, renal hypoxia accelerates CKD progression. To eliminate this vicious cycle, hypoxia-related therapies, such as hypoxi... |
Keratoconus with Central Serous Chorioretinopathy: A Rare Combination
Keratoconus and central serous chorioretinopathy are two rare diseases. They can occur together in some individuals. We report a case of a 48-year-old man, who presented to our clinic with decreased visual acuity on his left eye. Physical examinatio... |
Barriers to and Facilitators of Human Papillomavirus Vaccination Among People Aged 9 to 26 Years: A Systematic Review
Background: Cervical and oropharyngeal cancers are associated with human papillomavirus (HPV) infection, which can be prevented with the vaccines. However, uptake of the HPV vaccine remains low in many... |
Case report
Introduction: Amyloid light chain (AL) results from the deposition of immunoglobulin light chain fragments, and can affect multiple organs/systems. Our patient was diagnosed as scleroderma repeatedly because of extensive skin thickening and hardening, but the treatment was not effective. We did extensive l... |
Directional local field potentials: A tool to optimize deep brain stimulation
[bib_ref] Directional deep brain stimulation: an intraoperative double-blind pilot study, Pollo [/bib_ref] [bib_ref] Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease..., Timmermann [/bib... |
Effect of Genomic and Amino Acid Sequence Mutation on Virulence and Therapeutic Target of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS COV-2)
The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It is one of the RNA coronaviruses which share the highest mutation rat... |
Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy
Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, norma... |
Environmental Factors and Ventilation Affect Concentrations of Microorganisms in Hospital Wards of Southern Thailand
Hospitals tend to have high density of occupancy. Poor indoor environmental quality in hospital buildings can exacerbate the health problems of patients and also harm visitors and staff. is study invest... |
Stochastic dynamics of macromolecular-assembly networks
The formation and regulation of macromolecular complexes provides the backbone of most cellular processes, including gene regulation and signal transduction. The inherent complexity of assembling macromolecular structures makes current computational methods stron... |
Delocalization of Electrons in Strong Insulators at High Dynamic Pressures
Systematics of material responses to shock flows at high dynamic pressures are discussed. Dissipation in shock flows drives structural and electronic transitions or crossovers, such as used to synthesize metallic liquid hydrogen and most probab... |
Role of Intelligent Management Systems in Surgical Punctuality and Quality of Care
Objective. e main objective is to illustrate the role of intelligent management systems in surgical punctuality and quality of care. Methods. 72 registered nurses were selected from our operating room, and 180 patients who needed surger... |
Easy and Versatile Synthesis of Bulk Quantities of Highly Enriched 13C-Graphene Materials for Biological and Safety Applications
[bib_ref] Scalable production of large quantities of defect-free few-layer graphene by shear exfoliation..., Paton [/bib_ref] [bib_ref] Highly Decoupled Graphene Multilayers: Turbostraticit... |
Synthesis of Quinolin-2-one Alkaloid Derivatives and Their Inhibitory Activities against HIV-1 Reverse Transcriptase
Based on an established common pharmacophore of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNTTIs), a series of quinolin-2-one derivatives were synthesized and assayed for their in vitro act... |
An Update on the Implications of New Psychoactive Substances in Public Health
Citation: Simão, A.Y.; Antunes, M.; Cabral, E.; Oliveira, P.; Rosendo, L.M.; Brinca, A.T.; Alves, E.; Marques, H.; Rosado, T.; Passarinha, L.A.; et al. An
# Brief introduction
According to the United Nations Office on Drugs and Crime (UNODC... |
Dual Action of Lysophosphatidate-Functionalised Titanium: Interactions with Human (MG63) Osteoblasts and Methicillin Resistant Staphylococcus aureus
Titanium (Ti) is a widely used material for surgical implants; total joint replacements (TJRs), screws and plates for fixing bones and dental implants are forged from Ti.... |
The spike glycoprotein of SARS-CoV-2: A review of how mutations of spike glycoproteins have driven the emergence of variants with high transmissibility and immune escape
[bib_ref] Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus, Sevajol [/bib_ref] [bib_ref] Coronaviruses lacking ... |
Ganzfeld Stimulation or Sleep Enhance Long Term Motor Memory Consolidation Compared to Normal Viewing in Saccadic Adaptation Paradigm
Adaptation of saccade amplitude in response to intra-saccadic target displacement is a type of implicit motor learning which is required to compensate for physiological changes in sacca... |
Which urban land covers/uses are associated with residents’ mortality? A cross-sectional, ecological, pan-European study of 233 cities
Strengths and limitations of this study ► This was a large international study of 233 cities within 24 countries. ► We used high-quality, internationally comparable land cover/use data... |
Comparison of cardiovascular response to sinusoidal and constant lower body negative pressure with reference to very mild whole-body heating
Background:The purpose of the present study was to compare sinusoidal versus constant lower body negative pressure (LBNP) with reference to very mild whole-body heating. Sinusoid... |
Design of Artificial Enzymes Bearing Several Active Centers: New Trends, Opportunities and Problems
# Introduction
Humankind demands that chemical production should be as sustainable and clean as possible [bib_ref] Green Chemistry: Principles and Practice, Anastas [/bib_ref] [bib_ref] Fundamentals of green chemistry... |
The use of statins was associated with reduced COVID-19 mortality: a systematic review and meta-analysis
Background: Statins are widely used to treat people with metabolic and cardiovascular disorders. The effect of statins on coronavirus disease 2019 (COVID-19) is unclear. To investigate the association between stati... |
Obesity and Cancer Metastasis: Molecular and Translational Perspectives
Simple Summary: A major challenge in treating cancer is when the cancer spreads from its original site to other parts of the body, a process also known as metastasis. In order to survive, the cancer cells must communicate with their environment fo... |
Acute exacerbation of unclassifiable idiopathic interstitial pneumonia: comparison with idiopathic pulmonary fibrosis
Background: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is well known as a lifethreatening condition during its clinical course. However, the clinical features and prognosis in AE of u... |
Accurate Sparse-Projection Image Reconstruction via Nonlocal TV Regularization
Sparse-projection image reconstruction is a useful approach to lower the radiation dose; however, the incompleteness of projection data will cause degeneration of imaging quality. As a typical compressive sensing method, total variation has... |
Characterization of Inner Retinal Hyperreflective Alterations in Early Cognitive Impairment on Adaptive Optics Scanning Laser Ophthalmoscopy
Citation: Zhang YS, Onishi AC, Zhou N, et al. Characterization of inner retinal hyperreflective alterations in early cognitive impairment on adaptive optics scanning laser ophtha... |
N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality.To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs-such ... |
The human DEAD-box helicase DDX3X as a regulator of mRNA translation
The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins, it has non-conventional functions that are independent of its enzymatic activity, e... |
Alcohol use in opioid agonist treatment
Alcohol misuse among individuals receiving agonist treatment for an opioid use disorder is common and is associated with significant morbidity and mortality. At present, though substantial research highlights effective strategies for the screening, diagnosis and management of an... |
Rhein for treating diabetes mellitus: A pharmacological and mechanistic overview
With the extension of life expectancy and changes in lifestyle, the prevalence of diabetes mellitus is increasing worldwide. Rheum palmatum L. a natural botanical medicine, has been used for thousands of years to prevent and treat diabete... |
The roles of highly conserved, non‐catalytic residues in class A β‐lactamases
S2Supplementary Figure 1. Gels displaying soluble fractions of cell cultures expressing WT and mutant BlaC. NCnegative control, cells containing empty vector. Red frame shows the position of BlaC at 31 kDa, green frame shows the position of ... |
Phase Diagram for a Lysyl‐Phosphatidylglycerol Analogue in Biomimetic Mixed Monolayers with Phosphatidylglycerol: Insights into the Tunable Properties of Bacterial Membranes
Ion pairing between the major phospholipids of the Staphylococcus aureus plasma membrane (phosphatidylglycerol -PG and lysyl-phosphatidylglycerol... |
Memory and communication efficient algorithm for decentralized counting of nodes in networks
Node counting on a graph is subject to some fundamental theoretical limitations, yet a solution to such problems is necessary in many applications of graph theory to real-world systems, such as collective robotics and distribu... |
Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors
Innovative immunotherapies based on immune checkpoint targeting antibodies and engineered T cells are transforming the way we approach cancer treatment. However, although these T cell centered strategies result in marked and durable... |
The social contagion of temporal discounting in small social networks
Decisions often require a tradeoff between immediate and long-term gratification. How individuals resolve such tradeoffs reflects constructs such as temporal discounting, the degree that individuals devalue delayed rewards. Recent research has start... |
Protocol for a Delphi consensus exercise to identify a core set of criteria for selecting health related outcome measures (HROM) to be used in primary health care
Background: Promoting the collection and use of health related outcome measures (HROM) in daily practice has long been a goal for improving and assessing th... |
A seeded propagation of Cu, Zn-superoxide dismutase aggregates in amyotrophic lateral sclerosis
# Introduction
Many proteins gain physiological functions by folding into their own unique three-dimensional structures, and any disturbance during this folding process potentially disrupts protein functions, which is con... |
COVID-19 and Cardiac Arrhythmias: a Contemporary Review
Purpose of Review A significant proportion of patients infected by the severe acute respiratory syndrome-coronavirus (SARS-CoV2) (COVID-19) also have disorders affecting the cardiac rhythm. In this review, we provide an in-depth review of the pathophysiological m... |
Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions
Long noncoding RNAs (lncRNAs) regulate gene expression via their RNA product or through transcriptional interference, yet a strategy to differentiate these two processes is lacking. To address this, we... |
Global biogeography of SAR11 marine bacteria
## Figure s3
Shifts in sea surface temperature predicted from IPCC climate models.
## Table s1
Source of sequences making up the SAR11 ITS database.
## Table s2
Metagenome sample sets used in this study.
## Table s3
Environmental data associated with metagenomes used i... |
Child development: analysis of a new concept1
# Introduction
Child Development (CD) is a fundamental part of human development, emphasizing that the brain architecture is shaped in the first years, from the interaction of genetic inheritance and influences of the environment in which the child lives [bib_ref] The Li... |
Permeability Measures Predict Hemorrhagic Transformation after Ischemic Stroke
Objective: We sought to examine the diagnostic utility of existing predictors of any hemorrhagic transformation (HT) and compare them with new perfusion imaging permeability measures in ischemic stroke patients receiving alteplase only. Met... |
Diet-Quality Scores and Prevalence of Nonalcoholic Fatty Liver Disease: A Population Study Using Proton-Magnetic Resonance Spectroscopy
Objective Knowledge of the epidemiology of nonalcoholic fatty liver disease (NAFLD) is incomplete because liver biopsy cannot be performed on the general population to assess disease ... |
The grain quality of wheat wild relatives in the evolutionary context
Key message We evaluated the potential of wheat wild relatives for the improvement in grain quality characteristics including micronutrients (Fe, Zn) and gluten and identified diploid wheats and the timopheevii lineage as the most promising resource... |
Trends in socioeconomic inequalities in five major risk factors for cardiovascular disease in the Korean population: a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey, 2001–2014
MenEducation(yr) ≥13 56.
## Men
Education(yr) ≥13 56.6(56.6-56.7) 46.6(46.5-46.7) 42.0(41.9... |
A Mechanistic Review of β-Carotene, Lutein, and Zeaxanthin in Eye Health and Disease
Carotenoids are natural lipid-soluble antioxidants abundantly found as colorful pigments in fruits and vegetables. At least 600 carotenoids occur naturally, although about 20 of them, including β-carotene, α-carotene, lycopene, lutein... |
Venom immunotherapy: safety and tolerability of the build‐up phase with depot versus aqueous preparations
## R e s e a r c h l e t t e r venom immunotherapy: safety and tolerability of the build-up phase with depot versus aqueous preparations
To the Editor, Insect stings can cause an allergic reaction ranging from l... |
COVID-19 what have we learned? The rise of social machines and connected devices in pandemic management following the concepts of predictive, preventive and personalized medicine
Objectives Review, compare and critically assess digital technology responses to the COVID-19 pandemic around the world. The specific point ... |
HMDB 3.0—The Human Metabolome Database in 2013
The Human Metabolome Database (HMDB) (www. hmdb.ca) is a resource dedicated to providing scientists with the most current and comprehensive coverage of the human metabolome. Since its first release in 2007, the HMDB has been used to facilitate research for nearly 1000 pub... |
Utility of 3-D printing for cardiac resynchronization device implantation in congenital heart disease
# Introduction
Three-dimensional (3D) printing is increasingly being used to visualize relationships of anatomical structures and is becoming more popular in planning cardiac procedures. [bib_ref] Cardiac 3D printin... |
Coronavirus Pandemic: What Nuclear Medicine Departments Should Know
## Severe acute respiratory syndrome coronavirus 2
COVID-19 is caused by a novel b-coronavirus (1) that has been given the name ''severe acute respiratory syndrome coronavirus 2'' (SARS-CoV-2). It belongs to the Coronaviridae family and is an envelo... |
Cisplatin resistance-related multi-omics differences and the establishment of machine learning models
Objectives: Platinum-based chemotherapies are currently the first-line treatment of non-small cell lung cancer. This study will improve our understanding of the causes of resistance to cisplatin, especially in lung ad... |
Nuclear glycogenolysis modulates histone acetylation: a novel mechanism of epigenetic regulation in cancer
Nuclear glycogenolysis modulates histone acetylation: a novel mechanism of epigenetic regulation in cancer Open Access Cancer Communicationsdongxifeng@sdu.edu.cnNuclear glycogenolysis modulates histone acetylatio... |
Seroconversion after anti‐SARS‐CoV‐2 mRNA vaccinations among moderate‐to‐severe psoriatic patients receiving systemic biologicals—Prospective observational cohort study
It is unclear whether biological antipsoriatic therapies affect seroconversion after messenger ribonucleic acid (mRNA)-based antisevere acute respirat... |
Spontaneous Neural Dynamics and Multi-scale Network Organization
Spontaneous neural activity has historically been viewed as task-irrelevant noise that should be controlled for via experimental design, and removed through data analysis. However, electrophysiology and functional MRI studies of spontaneous activity patt... |
Allosteric Recognition of Homomeric and Heteromeric Pairs of Monosaccharides by a Foldamer Capsule
The recognition of either homomeric or heteromeric pairs of pentoses in an aromatic oligoamide double helical foldamer capsule was evidenced by circular dichroism (CD), NMR spectroscopy, and X-ray crystallography.T he ca... |
Post‐COVID‐19 fatal Aspergillus endocarditis: A case report
## | introduc ti on
Aspergillus endocarditis (AE) has been reported in immunocompromised and immunocompetent patients with a history of open-heart surgery, valve replacement, or intravenous drug use. The high mortality rate among survivors is very important... |
Vitamin E Acetate as a Plausible Cause of Acute Vaping-related Illness
# Introduction and background
"Vaping" (i.e., heating) is the practice of inhaling an aerosol created by heating a liquid or wax containing substances, such as nicotine, cannabinoids such as tetrahydrocannabinol (THC), cannabidiol, additives, and... |
Random selection of factors preserves the correlation structure in a linear factor model to a high degree
In a very high-dimensional vector space, two randomly-chosen vectors are almost orthogonal with high probability. Starting from this observation, we develop a statistical factor model, the random factor model, in ... |
Motor intervention with and without Nintendo® Wii for children with developmental coordination disorder: protocol for a randomized clinical trial
Background: Despite the benefits highlighted by motor interventions based on virtual reality for children with Developmental Coordination Disorder (DCD), there are still dou... |
Development and psychometric testing of an abridged version of Dundee Ready Educational Environment Measure (DREEM)
Background: Dundee Ready Educational Environment Measure (DREEM) is a 50-item tool to assess the educational environment of medical institutions as perceived by the students. This cross-sectional study d... |
Induced abortion and effecting factors of ever married women in the Southeast Anatolian Project Region, Turkey: a cross sectional study
Background: Nearly 10% of the population of Turkey lives in the Southeast Anatolian Project (SEAP) region. The population growth rate and the rate of unintended pregnancies are high a... |
Assessing infant cognition in field settings using eye-tracking: a pilot cohort trial in Sierra Leone
Objectives To investigate the feasibility of eyetracking-based testing of the speed of visual orienting in malnourished young children at rural clinics in Sierra Leone. Design Prospective dual cohort study nested in a... |
First Case Report of Developmental Bilateral Cataract with a Novel Mutation in the ZEB2 Gene Observed in Mowat-Wilson Syndrome
Background: Mowat-Wilson syndrome (MWS) is extremely rare multisystemic autosomal dominant disorder caused by mutations in the Zinc Finger E-Box Binding Homeobox 2 (ZEB2) gene. Ocular patholog... |
Safety and immunogenicity of a hybrid-type vaccine booster in BBIBP-CorV recipients in a randomized phase 2 trial
is a potential broad-spectrum recombinant COVID-19 vaccine that integrates the antigens from multiple SARS-CoV-2 strains into a single immunogen. Here, we evaluate the safety and immunogenicity of NVSI-06-... |
Validation of Visual Analogue Scales of job demand and job control at the workplace: a cross-sectional study
Supplementary Appendix 2 Relationships between each visual analog scale and items of Karasek questionnaire
Supplementary Appendix 2 Relationships between each visual analog scale and items of Karasek questionna... |
Cholesterol Slows down the Lateral Mobility of an Oxidized Phospholipid in a Supported Lipid Bilayer
We investigated the mobility and phase-partitioning of the fluorescent oxidized phospholipid analogue 1-palmitoyl-2-glutaroyl-sn-glycero-3-phospho-N-Alexa647-ethanolamine (PGPE-Alexa647) in supported lipid bilayers. Co... |
Sensitive and quantitative detection of cardiac troponin I with upconverting nanoparticle lateral flow test with minimized interference
Measurement of cardiac troponin I (cTnI) should be feasible for point-of-care testing (POCT) to diagnose acute myocardial infarction (AMI). Lateral flow immunoassays (LFIAs) have been... |
The Emerging Applications of Nanotechnology in Neuroimaging: A Comprehensive Review
Neuroimaging modalities such as computer tomography and magnetic resonance imaging have greatly improved in their ability to achieve higher spatial resolution of neurovascular and soft tissue neuroanatomy, allowing for increased accura... |
The APOE ε4 exerts differential effects on familial and other subtypes of Alzheimer's disease
Introduction: The genetic risk effects of apolipoprotein E (APOE) on familial Alzheimer's disease (FAD) with or without gene mutations, sporadic AD (SAD), and normal controls (NC) remain unclear in the Chinese population. Met... |
A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence
# Introduction
Cellular senescence is an aging-related growth arrest of cells that contributes to the pathology of many diseases of the elderly, such as diabetes, cardiovascular disease, and cancer 1,2 . Senescence w... |
Genetic polymorphism of merozoite surface protein 2 and prevalence of K76T pfcrt mutation in Plasmodium falciparum field isolates from Congolese children with asymptomatic infections
Background: In order to prepare the field site for future interventions, the prevalence of asymptomatic Plasmodium falciparum infection ... |
Effect of atorvastatin on iron metabolism regulation in patients with chronic kidney disease – a randomized double blind crossover study
Introduction:To determine the effect of 6-month administration of atorvastatin on hepcidin and hemojuvelin levels, inflammatory parameters and iron metabolism in patients with chroni... |
Elevated Striatal Dopamine Function in Immigrants and Their Children: A Risk Mechanism for Psychosis
Migration is a major risk factor for schizophrenia but the neurochemical processes involved are unknown. One candidate mechanism is through elevations in striatal dopamine synthesis and release. The objective of this r... |
Development of Walking indicators to advance the quality of spinal cord injury rehabilitation: SCI-High Project
Objective: To describe the development of structure, process and outcome indicators that will advance the quality of walking rehabilitation for Canadians with spinal cord injury or disease (SCI/D) by 2020. M... |
Relationship Between Diffusion Tensor Imaging (DTI) Findings and Cognition Following Pediatric TBI: A Meta-Analytic Review
This study meta-analyzed research examining relationships between diffusion tensor imaging and cognition following pediatric traumatic brain injury (TBI). Data from 14 studies that correlated frac... |
Evaluating the psychometric properties of an e-based version of the 39-item Parkinson’s Disease Questionnaire
Background: The 39-item Parkinson's Disease Questionnaire (PDQ-39) is the most thoroughly validated and extensively used self-report measure for the assessment of health-related quality of life in people with ... |
Ridinilazole, a narrow spectrum antibiotic for treatment of Clostridioides difficile infection, enhances preservation of microbiota-dependent bile acids
CM. Ridinilazole, a narrow spectrum antibiotic for treatment of Clostridioides difficile infection, enhances preservation of microbiota-dependent bile acids.
# Intro... |
Adipose tissue area as a predictor for the efficacy of apatinib in platinum-resistant ovarian cancer: an exploratory imaging biomarker analysis of the AEROC trial
Background: Vascular endothelial growth factor (VEGF)-targeted therapy is effective in patients with ovarian cancer. Whether adipose tissue (AT) could predi... |
Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population
A B S T R A C TBackground: Inherited methylmalonic acidemia is characterized by mitochondrial dysfunction, oxidative stress, and da... |
Validation of automated Alberta Stroke Program Early CT Score (ASPECTS) software for detection of early ischemic changes on non-contrast brain CT scans
Purpose In ASPECTS, 10 brain regions are scored visually for presence of acute ischemic stroke damage. We evaluated automated ASPECTS in comparison to expert readers. ... |
Oral management of a patient with down syndrome and agammaglobulinemia: a case report
Background: Down syndrome is characterized by a variety of dysmorphic features and congenital malformations, such as congenital heart disease, gastrointestinal disease, and other conditions like leukemia and autoimmune disorders. Pat... |
Internalized Sexual Stigma among Lesbian, Gay, and Bisexual Individuals in Taiwan: Its Related Factors and Association with Mental Health Problems
# Introduction
## Internalized stigma
Internalized stigma is a process whereby individuals endorse stereotypes about their personal characteristics, such as race and eth... |
Remote cognitive assessment in severe mental illness: a scoping review
Many individuals living with severe mental illness, such as schizophrenia, present cognitive deficits and reasoning biases negatively impacting clinical and functional trajectories. Remote cognitive assessment presents many opportunities for advanc... |
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