Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Architecture and adhesive activity of the Haemophilus influenzae Hsf adhesin. | Haemophilus influenzae type b is an important cause of meningitis and other serious invasive diseases and initiates infection by colonizing the upper respiratory tract. Among the major adhesins in H. influenzae type b is a nonpilus protein called Hsf, a large protein that forms fiber-like structures on the bacterial su... | ['Adhesins, Bacterial', 'Amino Acid Sequence', 'Bacterial Adhesion', 'Cell Line', 'Epithelial Cells', 'Haemophilus influenzae type b', 'Humans', 'Models, Molecular', 'Molecular Sequence Data', 'Protein Structure, Tertiary', 'Sequence Alignment'] | 15,968,077 | [['D12.776.097.120.050', 'D12.776.543.100.050', 'D23.050.161.050'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G06.099.050'], ['A11.251.210'], ['A11.436'], ['B03.440.450.600.450.330.150', 'B03.660.250.550.290.330.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['L01.453.245.667'], ['G02.111.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cloning of three endoglucanase genes from Thermomonospora curvata into Escherichia coli. | A BamHI genomic library from Thermomonospora curvata was constructed in E. coli using cosmid vector pHC79. Four clones able to hydrolyze CMC were isolated. Restriction digests and Southern gel analysis revealed the presence of three different endoglucanase genes. DNA fragments contained in all of the endoglucanase cosm... | ['Bacteria', 'Bacterial Proteins', 'Cellulase', 'Cloning, Molecular', 'Cosmids', 'DNA, Bacterial', 'Escherichia coli', 'Genes, Bacterial', 'Recombinant Proteins'] | 1,366,986 | [['B03'], ['D12.776.097'], ['D08.811.277.450.420.200.200'], ['E05.393.220'], ['G05.360.337.500', 'G05.360.600.250'], ['D13.444.308.212'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['D12.776.828']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gamma spectrometric measurements of depth-related radionuclide distribution in walls. | The method for depth-related radionuclide distribution was evolved for approximate determination of the spatial lay-out of radionuclides in materials. The method is based on different attenuation coefficients for various energies of gamma radiation. For each material, the attenuation coefficient decreases with rising e... | ['Algorithms', 'Construction Materials', 'Radiation Dosage', 'Radioisotopes', 'Radiometry', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Spectrometry, Gamma'] | 19,857,972 | [['G17.035', 'L01.224.050'], ['J01.637.241'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['D01.496.749'], ['E05.799'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.44... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Women's experiences with second trimester prenatal diagnosis. | By means of questionnaires, 100 women were asked for their experiences concerning prenatal diagnosis. At four standardized stages of the pregnancy a questionnaire was filled in asking for: expectation, knowledge, attitude towards termination of the pregnancy in case of abnormal findings, reactions to the counselling an... | ['Abortion, Induced', 'Amniocentesis', 'Attitude', 'Counseling', 'Decision Making', 'Female', 'Humans', 'Pregnancy', 'Pregnancy Trimester, Second', 'Prenatal Diagnosis', 'Risk', 'Surveys and Questionnaires'] | 7,145,848 | [['E04.520.050'], ['E01.370.225.500.384.050', 'E01.370.225.998.329.309', 'E01.370.378.630.050', 'E04.665.600.309', 'E05.200.500.384.050', 'E05.200.998.329.309', 'E05.242.384.050'], ['F01.100'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bone Marrow-Derived Mesenchymal Stem Cells Protect Islet Grafts Against Endoplasmic Reticulum Stress-Induced Apoptosis During the Early Stage After Transplantation. | Early loss of grafted islets is the main obstacle to achieve favorable outcomes of islet transplantation. Mesenchymal stem cells are known to have a protective effect; however, its mechanism remains unclear. We hypothesized that bone marrow-derived mesenchymal stem cells (BMSCs) can protect grafted islets against endop... | ['Animals', 'Apoptosis', 'Bone Marrow', 'Endoplasmic Reticulum Stress', 'Humans', 'Islets of Langerhans', 'Islets of Langerhans Transplantation', 'Mesenchymal Stem Cells', 'Mice', 'Mice, Inbred BALB C'] | 29,569,832 | [['B01.050'], ['G04.146.954.035'], ['A15.382.216'], ['G04.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.734.414', 'A06.300.414'], ['E02.095.147.500.250', 'E04.270.550', 'E04.936.225.375'], ['A11.329.830.500', 'A11.872.590.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Met5-enkephalin-Arg6-Gly7-Leu8 immunoreactivity in the human gut. | The presence of the proenkephalin A-derived peptide Met5-enkephalin-Arg6-Gly7-Leu8 was demonstrated throughout the human gastrointestinal tract. Highest concentrations of Met5-enkephalin-Arg6-Gly7-Leu8, as assessed by radioimmunoassay, were measured in the separated muscularis externa, while lower levels were found in ... | ['Colon', 'Cross Reactions', 'Digestive System', 'Enkephalin, Methionine', 'Gastric Mucosa', 'Gastrointestinal Neoplasms', 'Humans', 'Immune Sera', 'Intestinal Mucosa', 'Intestine, Small', 'Radioimmunoassay', 'Rectum', 'Stomach'] | 3,797,340 | [['A03.556.124.526.356', 'A03.556.249.249.356'], ['G12.122.281'], ['A03'], ['D12.644.400.575.281.381', 'D12.776.631.650.575.281.381'], ['A03.556.875.875.440', 'A10.615.550.291'], ['C04.588.274.476', 'C06.301.371', 'C06.405.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A12.207.152.846.500', 'D12.776.124.486.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Service users, metaphors and teamworking in mental health. | Despite the United Kingdom's recent governmental mental health policy directives aimed at strengthening professional collaboration and increasing service user involvement, the prevailing mental health care culture remains steeped in a discourse of treatment and care, control and compliance and professional expertise. D... | ['Attitude to Health', 'Community Mental Health Services', 'Cooperative Behavior', 'Humans', 'Mental Disorders', 'Metaphor', 'Nursing Services', 'Patient Care Team', 'Psychiatric Nursing', 'Surveys and Questionnaires', 'United Kingdom'] | 15,544,662 | [['F01.100.150', 'N05.300.150'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['F01.145.813.115'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['K01.400.899.500', 'K01.752.798.500'], ['N02.421.539'], ['N04.590.715'], ['H02.478.676.710', 'N02.421.533.778'], ['E05.318.308.980', 'N05.715.360.300.80... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Humanities [K]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Hepatic and pancreatic metabolism and biliary excretion of the protease inhibitor camostat mesilate. | The hepatic metabolism and biliary and pancreatic excretion of the serine protease inhibitor camostat mesilate and its metabolites FOY-251 and GBA were studied in rats in vivo and in in sutu liver-perfusion experiments. After oral feeding (100 mg/kg) and iv infusion (5 mg/kg.h) of camostat mesilate, the original compou... | ['Administration, Oral', 'Animals', 'Benzoates', 'Bile', 'Gabexate', 'Guanidines', 'Liver', 'Male', 'Pancreas', 'Pancreatic Juice', 'Perfusion', 'Protease Inhibitors', 'Rats', 'Rats, Inbred Strains', 'Spectrophotometry, Ultraviolet'] | 1,787,334 | [['E02.319.267.100'], ['B01.050'], ['D02.241.223.100', 'D02.455.426.559.389.127'], ['A12.200.087'], ['D02.078.370.380'], ['D02.078.370'], ['A03.620'], ['A03.734'], ['A12.200.567'], ['E05.680'], ['D27.505.519.389.745'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ultrastructural studies on the morula in cattle. | Embryos at morula stage were ultrastructurally examined. Blastomeres of normal embryos are characterized by the presence of ribosomes, short single and branched cisterns of endoplasmic reticulum, small spherical mitochondria and vacuolar-granular structures. An enhanced autophagy and the presence of numerous and large ... | ['Animals', 'Blastomeres', 'Cattle', 'Microscopy, Electron', 'Morula', 'Ribosomes', 'Vacuoles'] | 2,238,797 | [['B01.050'], ['A11.872.700.250.130', 'A16.094'], ['B01.050.150.900.649.313.500.380.271'], ['E01.370.350.515.402', 'E05.595.402'], ['A16.615'], ['A11.284.430.214.190.875.811'], ['A11.284.430.214.190.875.190.920']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts of the knee at 3T MRI: a comparison between intermediate-weighted fat-suppressed spin echo and Dual Echo Steady State sequences. | BACKGROUND: Choice of appropriate MR pulse sequence is important for any research studies using imaging-derived data. The aim of this study was to compare semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts using intermediate-weighted (IW) fat-suppressed (fs) spin echo and Du... | ['Adult', 'Aged', 'Bone Cysts', 'Bone Marrow Diseases', 'Edema', 'Female', 'Humans', 'Image Interpretation, Computer-Assisted', 'Knee Joint', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Pain', 'Signal Processing, Computer-Assisted', 'Spin Labels'] | 21,906,292 | [['M01.060.116'], ['M01.060.116.100'], ['C04.182.089', 'C05.116.070'], ['C15.378.190'], ['C23.888.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['A02.835.583.475'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C23.888.592.612', 'F02.830.816... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Controlled-release methylphenidate improves attention during on-road driving by adolescents with attention-deficit/hyperactivity disorder. | BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with a 3- to 4-fold increase in both driving-related accidents and associated injuries. Methylphenidate (MPH) is the most commonly prescribed psychostimulant medication for ADHD. It has been demonstrated to improve performance on a driving simula... | ['Adolescent', 'Attention', 'Attention Deficit Disorder with Hyperactivity', 'Automobile Driving', 'Central Nervous System Stimulants', 'Drug Administration Schedule', 'Humans', 'Impulsive Behavior', 'Male', 'Methylphenidate', 'Treatment Outcome'] | 15,243,010 | [['M01.060.057'], ['F02.830.104.214'], ['F03.625.094.150'], ['I03.125'], ['D27.505.696.282', 'D27.505.954.427.220'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.527'], ['D02.241.223.601.600', 'D03.383.621.460'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Immortalization of subpopulations of respiratory epithelial cells from transgenic mice bearing SV40 large T antigen. | Murine lung epithelial (MLE) cell lines were produced from lung tumors derived from transgenic mice bearing the viral oncogene, SV40 large T antigen, under transcriptional control of the promoter-enhancer region of the human surfactant protein C (SP-C) gene. Cells were selected on the basis of increased murine cystic f... | ['Animals', 'Antigens, Polyomavirus Transforming', 'Cell Separation', 'Cell Transformation, Viral', 'Clusterin', 'Cystic Fibrosis Transmembrane Conductance Regulator', 'Epithelium', 'Glycoproteins', 'Lung', 'Membrane Proteins', 'Mice', 'Mice, Transgenic', 'Molecular Chaperones', 'RNA, Messenger', 'Tumor Cells, Cultured... | 7,524,342 | [['B01.050'], ['D12.776.624.664.520.090', 'D12.776.964.700.090', 'D23.050.285.062.090', 'D23.050.327.062.090'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['C04.697.098.500.160', 'C23.550.727.098.500.160', 'G06.920.143'], ['D12.776.395.207', 'D12.776.580.215'], ['D12.776.157.530.100.304.500', 'D12.776.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improving First Aid Management of Epilepsy by Trainee Teachers of the Federal College of Education (Technical), Akoka - Lagos, South West Nigeria--Can Health Education have an Effect? | BACKGROUND: lt is estimated that epilepsy affects approximately 50 million people worldwide and about 40 million of them live in developing countries. Studies have indicated high rates of poor knowledge, negative attitude and poor first aid management skills of students with epilepsy among practicing teachers. However,... | ['Adult', 'Epilepsy', 'Female', 'First Aid', 'Health Education', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Nigeria', 'Quality Improvement', 'Schools', 'Surveys and Questionnaires'] | 27,276,753 | [['M01.060.116'], ['C10.228.140.490'], ['E02.365.305'], ['I02.233.332', 'N02.421.726.407'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.058.290.190.565'], ['J01.293.754', 'N04.761.744'], ['I02.783', 'J03.832'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.30... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Inmunoferon, an immunomodulator of natural origin, does not affect the rat liver cytochrome P-450 and phase II conjugation enzymes. | Inmunoferon is a glycoconjugate of natural origin with immunomodulatory properties. It has recently been shown to regulate TNF-alpha expression induced by lipopolysaccharide (LPS) challenge through a hypothalamo-pituitary-adrenal (HPA)-dependent mechanism. Inmunoferon is orally administered to immunocompromised patient... | ['Adjuvants, Immunologic', 'Animals', 'Anti-Bacterial Agents', 'Biotransformation', 'Calcium Phosphates', 'Cytochrome P-450 Enzyme System', 'Glycopeptides', 'Liver', 'Macrolides', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Tumor Necrosis Factor-alpha'] | 12,743,622 | [['D27.505.696.477.067'], ['B01.050'], ['D27.505.954.122.085'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['D01.029.260.700.675.374.075', 'D01.146.360', 'D01.695.625.675.650.075'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['D09.400.420', 'D12.644.233'], ['A03.620'], ['D02.540.505', 'D02.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical validity of a Personality Inventory for Children (PIC) profile typology. | We evaluated the validity of a profile typology for the Personality Inventory for Children (PIC), a parent-informant measure of child psychiatric status. For referred children, we studied (a) the convergence of PIC profile types with diagnoses according to the Diagnostic and Statistical Manual of Mental Disorders (3rd ... | ['Child', 'Child Behavior Disorders', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Personality Assessment', 'Personality Inventory', 'Psychometrics', 'Reproducibility of Results', 'Social Environment'] | 1,613,660 | [['M01.060.406'], ['F03.625.141'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F04.513'], ['F04.711.647.513'], ['F04.711.780'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['I01.880.853.500']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Trace element content of commercial shampoos: impact on trace element levels in hair. | Popular shampoos were screened for their contents in trace elements, using ICP-MS detection in a semi-quantitative mode. Hair samples from volunteers were analyzed before and after hair washing with selected shampoos to demonstrate the effect of the contamination and the impact on occupational medicine. While some sham... | ['Hair', 'Hair Preparations', 'Humans', 'Mass Spectrometry', 'Trace Elements'] | 10,418,166 | [['A17.360'], ['D27.720.269.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.566'], ['D01.268.811', 'D27.505.696.494.555', 'G07.203.300.681.500.555', 'J02.500.681.500.555']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Antigenic changes in cultured murine lymphomas after retransplantation into syngeneic hosts. | When cultured murine lymphomas were retransplanted into syngeneic hosts, the quantitative representation of H-2 antigens and Moloney leukemia virus-determined cell-surface antigens tended to revert to the antigenic pattern characteristic of the corresponding lines propagated in vivo. In some instances, a complete rever... | ['Animals', 'Antigen-Antibody Reactions', 'Antigens, Neoplasm', 'Antigens, Viral', 'Cells, Cultured', 'Lymphoma', 'Mice', 'Moloney murine leukemia virus', 'Neoplasm Transplantation', 'Neoplasms, Experimental', 'Transplantation, Homologous'] | 1,127,719 | [['B01.050'], ['G12.122'], ['D23.050.285'], ['D23.050.327'], ['A11.251'], ['C04.557.386', 'C15.604.515.569', 'C20.683.515.761'], ['B01.050.150.900.649.313.992.635.505.500'], ['B04.613.807.375.525.596', 'B04.820.650.375.525.596'], ['E05.624'], ['C04.619', 'E05.598.500.496'], ['E04.936.864']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Renal tubular acidosis associated with type III glycogenosis. | Two children who presented with severe failure to thrive were found to have Type III glycogen storage disease. They both also had defects of tubular acidification, an association not previously described. The nature of the tubular lesion is characterized and the explanation and therapeutic implications are discussed. | ['Acidosis, Renal Tubular', 'Glycogen Storage Disease', 'Glycogen Storage Disease Type III', 'Humans', 'Infant', 'Infant, Newborn', 'Male'] | 294,126 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MS1 Peptide Ion Intensity Chromatograms in MS2 (SWATH) Data Independent Acquisitions. Improving Post Acquisition Analysis of Proteomic Experiments. | Quantitative analysis of discovery-based proteomic workflows now relies on high-throughput large-scale methods for identification and quantitation of proteins and post-translational modifications. Advancements in label-free quantitative techniques, using either data-dependent or data-independent mass spectrometric acqu... | ['Animals', 'High-Throughput Screening Assays', 'Liver', 'Mice', 'Peptides', 'Protein Kinase Inhibitors', 'Proteomics', 'Reproducibility of Results', 'Software'] | 25,987,414 | [['B01.050'], ['E05.916.680'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.644'], ['D27.505.519.389.755'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['L01.224.900']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
p42-MAP kinase is activated in EGF-stimulated interphase but not in metaphase-arrested HeLa cells. | It is known that cellular signals produced in response to an inappropriate spindle formation cause the cell to be arrested at metaphase (M) in the cell cycle. We report here that the 42-kDa isoform of MAPK (ERK2) was tyrosyl-phosphorylated and activated in response to epidermal growth factor (EGF) in interphase but not... | ['Enzyme Activation', 'Epidermal Growth Factor', 'ErbB Receptors', 'HeLa Cells', 'Humans', 'Interphase', 'Metaphase', 'Mitogen-Activated Protein Kinase 1', 'Phosphorylation', 'Tyrosine'] | 9,989,589 | [['G02.111.263', 'G03.328'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative Effectiveness and Safety of Polymer-Free Biolimus-Eluting Stent and Durable Polymer Everolimus-Eluting Stent in All-Comer Patients Who Underwent Percutaneous Coronary Interventions. | We aim to compare Polymer-Free Biolimus-Eluting Stent (PF-BES) with Durable Polymer Everolimus-Eluting stent (DP-EES) in unselected patients. PF-BES showed a favorable profile in high-bleeding risk patients who underwent percutaneous coronary intervention. Limited data are available on PF-BES compared with second-gener... | ['Absorbable Implants', 'Aged', 'Drug-Eluting Stents', 'Everolimus', 'Female', 'Follow-Up Studies', 'Humans', 'Immunosuppressive Agents', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Percutaneous Coronary Intervention', 'Prospective Studies', 'Prosthesis Design', 'Sirolimus', 'Treatment Outcome'] | 31,103,132 | [['E07.695.025'], ['M01.060.116.100'], ['E07.695.750.500'], ['D02.540.505.760.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nutritional development and the target weight debate. | Postnatal nutrition has immediate and long-lasting effects on beef heifer reproductive efficiency, longevity, and productivity. This article reviews the effects of nutrients and nutritional management on reproduction in developing heifers. In addition, the current debate on the preferred target weight for heifers at br... | ['Animal Husbandry', 'Animal Nutritional Physiological Phenomena', 'Animals', 'Body Weight', 'Breeding', 'Cattle', 'Female', 'Food Industry', 'Meat', 'Nutritional Status', 'Reproduction', 'Sexual Development'] | 24,182,433 | [['J01.040.090'], ['G07.203.650.161'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E05.820.150', 'G05.090'], ['B01.050.150.900.649.313.500.380.271'], ['J01.576.423'], ['G07.203.300.600', 'J02.500.600'], ['G07.203.650.650', 'N01.224.... | ['Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
The surface glycoprotein of a natural feline leukemia virus subgroup A variant, FeLV-945, as a determinant of disease outcome. | Feline leukemia virus (FeLV) is a natural retrovirus of domestic cats associated with degenerative, proliferative and malignant diseases. Studies of FeLV infection in a cohort of naturally infected cats were undertaken to examine FeLV variation, the selective pressures operative in FeLV infection that lead to predomina... | ['Animals', 'Cats', 'Leukemia Virus, Feline', 'Leukemia, Feline', 'Membrane Glycoproteins', 'Receptors, Virus'] | 21,764,142 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['B04.613.807.375.500', 'B04.820.650.375.500'], ['C01.925.782.815.622', 'C04.557.337.385', 'C22.180.500'], ['D12.776.395.550', 'D12.776.543.550'], ['D12.776.543.750.830']] | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immunohistochemical distribution of alpha-neo-endorphin/dynorphin neuronal systems in rat brain: evidence for colocalization. | alpha-Neo-endorphin and dynorphin immunoreactivities in rat brain were visualized by double antibody immunofluorescence of frozen sections. Antibodies were used that were specific for their respective antigens. The pattern of neuronal immunostaining produced by alpha-neo-endorphin and dynorphin antisera in adjacent ser... | ['Animals', 'Antibody Specificity', 'Brain', 'Colchicine', 'Dynorphins', 'Endorphins', 'Fluorescent Antibody Technique', 'Nerve Endings', 'Neurons', 'Protein Precursors', 'Rats'] | 6,124,001 | [['B01.050'], ['G12.100'], ['A08.186.211'], ['D03.132.225'], ['D12.644.400.575.180', 'D12.776.631.650.575.180'], ['D12.644.400.575.241', 'D12.776.631.650.575.241'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['A08.800.550'], [... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synergistic effects of BuChE non-UU phenotype and paraoxonase (PON1) 55 M allele on the risk of systemic lupus erythematosus: influence on lipid and lipoprotein metabolism and oxidative stress, preliminary report. | There is some evidence indicating lipid peroxidation can affect progression of atherosclerosis, cardiovascular diseases (CVDs) and glomerulonephritis in systemic lupus erythematosus (SLE) patients. Human butyrylcholinesterase (BuChE) and paraoxonase-1 (PON1) are two major bioscavenger enzymes that are associated with i... | ['Adolescent', 'Adult', 'Aged', 'Aryldialkylphosphatase', 'Biomarkers', 'Butyrylcholinesterase', 'Case-Control Studies', 'Cholesterol, LDL', 'Female', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Humans', 'Iran', 'Lipid Peroxidation', 'Lupus Erythematosus, Systemic', 'Male', 'Malondialdehyde', 'Middle Aged',... | 24,399,815 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D08.811.277.352.660.500'], ['D23.101'], ['D08.811.277.352.100.170.250'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'], ['G05.330'],... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Induction of hematopoietic cell apoptosis by the serum from immune-mediated aplastic anemia mice]. | OBJECTIVE: To explore the mechanism of the impairment of hematopoietic stem/progenitor cells in aplastic anemia(AA) mice.METHODS: The hematopoietic cells from normal mice bone marrow were incubated with serum from AA mice in the presence of recombinant GM-CSF and IL-3. Parallel controls, i.e. hematopoietic cells from n... | ['Anemia, Aplastic', 'Animals', 'Apoptosis', 'Cells, Cultured', 'Culture Media, Conditioned', 'Female', 'Hematopoietic Stem Cells', 'Immune Sera', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred DBA'] | 11,189,493 | [['C15.378.071.085', 'C15.378.190.223.250'], ['B01.050'], ['G04.146.954.035'], ['A11.251'], ['D27.720.470.305.250', 'E07.206.250'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.573', 'D12.776.377.715.548.114.573', 'D20.215.401'], ['B0... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Accidental guide catheter fracture in mechanical thrombectomy. | Endovascular thrombectomy is now the standard of care for large vessel occlusion stroke. The aim is to achieve rapid and complete recanalisation while avoiding complications. Apart from the conventional complications of neurointerventional procedures, mechanical thrombectomy has its unique set of complications, inheren... | ['Aged, 80 and over', 'Autopsy', 'Equipment Failure', 'Fatal Outcome', 'Humans', 'Infarction, Middle Cerebral Artery', 'Magnetic Resonance Imaging', 'Male', 'Stroke', 'Thrombectomy', 'Treatment Outcome'] | 30,463,502 | [['M01.060.116.100.080'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['E05.325'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.150.477.200.450', 'C10.228.140.300.510.200.387', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
ALG3 contributes to the malignancy of non-small cell lung cancer and is negatively regulated by MiR-98-5p. | OBJECTIVE: Alpha-1,3-mannosyltransferase (ALG3) is an oncoprotein associated with multiple malignancies. We aimed to investigate the role and potential mechanisms of ALG3 in non-small cell lung cancer (NSCLC).METHODS: We detected the expressions of ALG3 in NSCLC tissues and adjacent tissues by RT-PCR, western blot and ... | ['Biomarkers, Tumor', 'Carcinoma, Non-Small-Cell Lung', 'Cell Movement', 'Cell Proliferation', 'Disease Progression', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Lung Neoplasms', 'Mannosyltransferases', 'MicroRNAs', 'Prognosis'] | 31,899,049 | [['D23.101.140'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C23.550.291.656'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], [... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolation and some characteristics of a subgroup J-like avian leukosis virus associated with myeloid leukosis in meat-type chickens in the United States. | Several subgroup J-like avian leukosis viruses (ALV-Js) were isolated from broiler breeder (BB) and commercial broiler flocks experiencing myeloid leukosis (ML) at 4 wk of age or older. In all cases, diagnosis of ML was based on the presence of typical gross and microscopic lesions in affected tissues. The isolates wer... | ['Animals', 'Antigens, Viral', 'Avian Leukosis', 'Avian Leukosis Virus', 'Chick Embryo', 'Chickens', 'Kidney', 'Liver', 'Meat', 'Polymerase Chain Reaction', 'United States'] | 10,494,407 | [['B01.050'], ['D23.050.327'], ['C01.925.782.815.096', 'C01.925.928.120', 'C04.557.337.372.216', 'C04.619.531.216', 'C22.131.094'], ['B04.613.807.070.100', 'B04.820.650.070.100'], ['A13.350.150', 'A16.331.200'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['A05.810.453'], ['A03.620'], ['G07.203.300.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
[Carpal tunnel syndrome. Diagnostic and prognostic value of the tourniquet test]. | The tourniquet test devised by Gilliatt was used in 54 patients with carpal tunnel syndrome and its value was assessed in diagnosis and prognosis. The test procedures dysaesthesia in the median territory when the tourniquet is inflated above the systolic pressure. The value of the test was similar to that of electrical... | ['Carpal Tunnel Syndrome', 'Humans', 'Postoperative Period', 'Prognosis', 'Time Factors', 'Tourniquets'] | 6,234,623 | [['C10.668.829.500.500.200', 'C10.668.829.550.200', 'C26.844.150.206'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.614.750', 'N02.421.585.753.750'], ['E01.789'], ['G01.910.857'], ['E07.926']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
PGC-1á Controls Mitochondrial Biogenesis in Drug-Resistant Colorectal Cancer Cells by Regulating Endoplasmic Reticulum Stress. | Anti-cancer drug resistance is a serious issue for patients with colorectal cancer (CRC). Although recent studies have shown the mechanism by which CRC cells become drug resistant, novel strategies for overcoming this drug resistance have not yet been developed. To address this problem, we characterized 5-fluorouracil ... | ['Antioxidants', 'Apoptosis', 'Cell Line, Tumor', 'Colorectal Neoplasms', 'Cytoprotection', 'Drug Resistance, Neoplasm', 'Endoplasmic Reticulum Stress', 'Fluorouracil', 'Humans', 'Mitochondria', 'Models, Biological', 'Organelle Biogenesis', 'Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha', 'Reacti... | 30,959,809 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['G07.690.773.500'], ['G07.690.773.984.395'], ['G04... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Activity and synergistic antimicrobial activity between diketopiperazines against bacteria in vitro. | The aim of the present study was to determine the synergistic effects of diketopiperazines [cyclo-(L-Pro-L-Leu) (1), cyclo-(D-Pro-L-Leu) (2), and cyclo-(D-Pro-L-Tyr) (3)] purified from a Bacillus sp. N strain associated with entomopathogenic nematode Rhabditis (Oscheius) sp. on the growth of bacteria. The minimum inhib... | ['Anti-Bacterial Agents', 'Bacteria', 'Cell Line', 'Diketopiperazines', 'Drug Synergism', 'Humans', 'Microbial Sensitivity Tests'] | 23,070,715 | [['D27.505.954.122.085'], ['B03'], ['A11.251.210'], ['D03.383.606.385'], ['G07.690.773.968.477'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comprehensive population screening in the Ashkenazi Jewish population for recurrent disease-causing variants. | The Ashkenazi Jewish (AJ) population has an increased risk for a variety of recessive diseases due to historical founder effects and genetic drift. For some, the disease-causing founder mutations have been identified and well-characterized, but for others, further study is necessary. The purpose of this study is to ass... | ['Female', 'Founder Effect', 'Genes, Recessive', 'Genetic Carrier Screening', 'Genetic Diseases, Inborn', 'Genetic Predisposition to Disease', 'Genetic Testing', 'Genetics, Population', 'Genotype', 'Heterozygote', 'Humans', 'Jews', 'Male', 'Mutation'] | 27,415,407 | [['G05.285'], ['G05.360.340.024.340.415', 'G05.420.325'], ['E01.370.225.562.250', 'E05.200.562.250', 'E05.393.435.250', 'N02.421.308.200', 'N02.421.726.233.221.250'], ['C16.320'], ['C23.550.291.687.500', 'G05.380.355'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['H01.1... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Transcriptional Characterization of Stage I Epithelial Ovarian Cancer: A Multicentric Study. | Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, and... | ['Biomarkers, Tumor', 'Carcinoma, Ovarian Epithelial', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation, Neoplastic', 'Gene Regulatory Networks', 'Humans', 'Metabolic Networks and Pathways', 'Neoplasm Grading', 'Neoplasm Staging', 'Ovarian Neoplasms', 'Signal Transduction', 'Transcription, Genetic'] | 31,805,750 | [['D23.101.140'], ['C04.557.470.200.295', 'C04.588.322.455.199', 'C13.351.500.056.630.705.350', 'C13.351.937.418.685.350', 'C19.344.410.199', 'C19.391.630.705.350'], ['E05.393.332'], ['G05.308.370'], ['G05.360.080.689.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.493'], ['E01.789.612'], ['E01.789.625'],... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Need fulfillment in the sexual relationships of HIV-infected men who have sex with men. | This article explores the associations among sexual need fulfillment, partner selection, and risky sexual behavior, using a functional/motivational perspective. The authors suggest that sexual needs influence partner selection (e.g., steady versus nonsteady), and engaging in UAI is influenced by sexual needs and partne... | ['Adult', 'Aged', 'Anal Canal', 'Decision Making', 'HIV Seropositivity', 'Homosexuality, Male', 'Humans', 'Male', 'Middle Aged', 'Personal Satisfaction', 'Sexual Partners', 'Surveys and Questionnaires', 'United States', 'Unsafe Sex'] | 16,006,208 | [['M01.060.116'], ['M01.060.116.100'], ['A03.556.124.526.070', 'A03.556.249.249.070'], ['F02.463.785.373'], ['C01.221.250.875.500', 'C01.221.812.640.400.500', 'C01.778.640.400.500', 'C01.925.782.815.616.400.500', 'C01.925.813.400.500', 'C20.673.480.500'], ['F01.145.802.975.500.600', 'G08.686.867.500.600'], ['B01.050.15... | ['Named Groups [M]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Differential effects of Tyr-MIF-1, MIF-1, and naloxone on peptide YY-induced hyperphagia. | Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) and MIF-1 (Pro-Leu-Gly-NH2) act as opiate antagonists in various behavioral systems including ingestion. Central injection of peptide YY (PYY) elicits a powerful feeding response in satiated rats, and the opioid antagonist naloxone decreases eating in a variety of conditions including PY... | ['Animals', 'Behavior, Animal', 'Feeding Behavior', 'Hyperphagia', 'MSH Release-Inhibiting Hormone', 'Male', 'Naloxone', 'Peptide YY', 'Peptides', 'Rats', 'Rats, Sprague-Dawley'] | 7,911,993 | [['B01.050'], ['F01.145.113'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['C23.888.821.645'], ['D06.472.699.327.700.500', 'D12.644.400.400.700.500', 'D12.644.548.365.700.500', 'D12.776.631.650.405.700.500'], ['D03.132.577.249.706', 'D03.605.497.750', 'D03.633.400.686.750', 'D04.615.723.795.706'], ['D06.472... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Evaluation of MRI in the diagnosis of rheumatoid arthritis]. | OBJECTIVE: to study the features of rheumatoid arthritis (RA) on MRI of hands and wrists and compare MRI with clinical manifestations and laboratory tests of RA.METHODS: a total of 25 patients fulfilling the 2009 ACR/EULAR RA criteria were enrolled. MRI and plain films of hands and wrists and clinical data of swollen j... | ['Adolescent', 'Adult', 'Aged', 'Arthritis, Rheumatoid', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Young Adult'] | 21,211,324 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['M01.060.116.815']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Activities of rifamycin derivatives against wild-type and rpoB mutants of Chlamydia trachomatis. | Rifalazil, a semisynthetic rifamycin, was shown previously to have exceptional potency against Chlamydia trachomatis (MIC of 0.00025 microg/ml). We therefore tested 250 additional rifamycin derivatives and identified 12 with activities that are eightfold more potent than that of rifalazil. These compounds also showed e... | ['Anti-Bacterial Agents', 'Chlamydia Infections', 'Chlamydia trachomatis', 'Humans', 'Mutation, Missense', 'Rifamycins'] | 16,127,086 | [['D27.505.954.122.085'], ['C01.150.252.400.210.125', 'C01.150.252.734.301', 'C01.221.812.281.301', 'C01.778.281.301', 'C12.294.668.281.301', 'C13.351.500.711.281.301'], ['B03.440.190.190.190.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590.650'], ['D03.633.400.811', 'D04.345.295.750']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes. | The CXC chemokine stromal cell-derived factor (SDF)-1 is produced constitutively in different tissues. It is the only known ligand for CXCR4, which is widely expressed in leukocytes and in some tissue cells, and acts as coreceptor for X4 HIV strains. Because of the general interest in the mechanisms that regulate the a... | ['Amino Acid Sequence', 'B-Lymphocytes', 'Cathepsin G', 'Cathepsins', 'Cells, Cultured', 'Chemokine CXCL12', 'Chemokines, CXC', 'Humans', 'Killer Cells, Natural', 'Lymphocytes', 'Membrane Proteins', 'Molecular Sequence Data', 'Oligopeptides', 'Peptides', 'Serine Endopeptidases', 'Serine Proteinase Inhibitors', 'T-Lymph... | 11,241,273 | [['G02.111.570.060', 'L01.453.245.667.060'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['D08.811.277.656.224.350', 'D08.811.277.656.300.760.066', 'D08.811.277.656.959.350.066'], ['D08.811.277.656.224'], ['A11.251'], ['D12.644.276.374.200.120... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of region, herd size, and milk production on reasons cows leave the herd. | Dairy Herd Improvement Holstein herd summary records (n = 11,259) were obtained for the year ending 1998. Reasons cows reportedly left the herd based on termination codes were analyzed for the effect of region, herd size, and herd milk production level. Regions were: North, Midsouth, and South. Herd sizes were: small (... | ['Animals', 'Cattle', 'Female', 'Lactation', 'Mastitis, Bovine', 'Milk', 'Mortality', 'North America', 'Population Density', 'Reproduction', 'Retrospective Studies', 'South America'] | 11,132,870 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G08.686.523', 'G08.686.702.500'], ['C22.196.581'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.525', 'J02.200.700', 'J02.500.350.525'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.505.400.975.550', 'N06.850.520.308.985.550'], ['Z01.107.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Correct in vivo processing of a chimeric ubiquitin-proapolipoprotein A-I fusion protein in baculovirus-infected insect cells. | The cDNA coding for human proapolipoprotein A-I was expressed as a ubiquitin fusion under the control of the polyhedrin promoter in baculovirus-infected Sf9 Spodoptera frugiperda insect cells. The fusion protein was expressed at high level and was quantitatively cleaved in vivo. The cleaved product was purified and its... | ['Amino Acid Sequence', 'Animals', 'Apolipoprotein A-I', 'Apolipoproteins A', 'Baculoviridae', 'Base Sequence', 'Cell Line', 'DNA, Complementary', 'Electrophoresis, Polyacrylamide Gel', 'Humans', 'Lipoproteins, HDL', 'Molecular Sequence Data', 'Molecular Weight', 'Moths', 'Protein Precursors', 'Protein Processing, Post... | 7,764,450 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D10.532.091.200.100', 'D12.776.070.400.200.100', 'D12.776.521.120.200.100'], ['D10.532.091.200', 'D12.776.070.400.200', 'D12.776.521.120.200'], ['B04.280.065', 'B04.525.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['D13.44... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Analysis of the Complete Genome Sequence of Bacillus atrophaeus | Bacillus atrophaeus GQJK17 was isolated from the rhizosphere of Lycium barbarum L. in China, which was shown to be a plant growth-promoting rhizobacterium as a new biological agent against pathogenic fungi and gram-positive bacteria. We present its biological characteristics and complete genome sequence, which contains... | ['Bacillus', 'Biological Control Agents', 'China', 'Fungi', 'Genome, Bacterial', 'Lycium', 'Plant Development', 'Rhizosphere'] | 30,046,614 | [['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['D20.215.113'], ['Z01.252.474.164'], ['B01.300'], ['G05.360.340.358.207'], ['B01.650.940.800.575.912.250.908.500.310'], ['G07.345.625', 'G15.589'], ['G16.500.275.157.625', 'G16.500.853', 'N... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Surgical treatment of glioblastoma in the elderly: the impact of complications. | The diagnosis of glioblastoma (GBM) often carries a dismal prognosis, with a median survival of 14.6 months. A particular challenge is the diagnosis of GBM in the elderly population (age > 75 years), who have significant comorbidities, present with worse functional status, and are at higher risk with surgical treatment... | ['Aged', 'Aged, 80 and over', 'Aging', 'Brain Neoplasms', 'Female', 'Glioblastoma', 'Humans', 'Karnofsky Performance Status', 'Male', 'Neurosurgical Procedures', 'Postoperative Complications', 'Retrospective Studies'] | 29,392,589 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C04.557.465.625.600.380.080.335', 'C04.557.470.670.380.080.335', 'C04.557.580.625.600.380.080.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.980.438.475.456.500.500', '... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Randomized controlled trial of exercise training for older people (Sendai Silver Center Trial; SSCT): study design and primary outcome. | Physical exercise is expected to improve and maintain physical function in older people, thus promoting health and preventing or postponing the onset of disability in later life. The Sendai Silver Center Trial (SSCT) was a randomized controlled trial designed to evaluate the efficacy of exercise training among healthy ... | ['Aged', 'Aged, 80 and over', 'Aging', 'Exercise', 'Female', 'Geriatric Assessment', 'Health Promotion', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Oxygen Consumption', 'Physical Endurance', 'Research Design'] | 10,695,262 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['G11.427.410.698.277', 'I03.350'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Simultaneous infections with different serogroups of Legionella pneumophila investigated by routine methods and Fourier transform infrared spectroscopy. | Simultaneous infections with different Legionella spp. have rarely been described in the literature. We now report on seven sporadic cases of legionellosis of which three were simultaneous infections caused by multiple Legionella pneumophila serogroups. Four different legionellae were involved. L. pneumophila serogroup... | ['Humans', 'Legionella', "Legionnaires' Disease", 'Serotyping', 'Spectrophotometry, Infrared'] | 3,384,922 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.440.400.425.450.450', 'B03.660.250.460.460'], ['C01.150.252.400.500.501', 'C01.748.382.380', 'C08.730.382.380'], ['E01.370.225.812.742', 'E01.370.225.875.150.125.890', 'E05.200.812.742', 'E05.200.875.150.125.890', 'E05.478.594.780'], ['E05.196.712.726.676', 'E05.1... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
LncGPR107 drives the self-renewal of liver tumor initiating cells and liver tumorigenesis through GPR107-dependent manner. | BACKGROUND: With self-renewal and differentiation properties, liver tumor initiating cells (TICs) are the reasons for tumor initiation, metastasis and drug resistance. G protein coupled receptors (GPCR) are critical modulators in many physiological and pathological processes. While, their roles in liver TICs are unknow... | ['Aged', 'Animals', 'Biomarkers, Tumor', 'Carcinoma, Hepatocellular', 'Cell Line, Tumor', 'Cell Self Renewal', 'Cell Transformation, Neoplastic', 'Disease Models, Animal', 'Female', 'Gene Expression Regulation, Neoplastic', 'Heterografts', 'Humans', 'Liver Neoplasms', 'Male', 'Mice', 'Middle Aged', 'Neoplastic Stem Cel... | 29,925,408 | [['M01.060.116.100'], ['B01.050'], ['D23.101.140'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.144.220.235', 'G04.161.750.500.375', 'G05.113.415', 'G07.345.249.410.750.500.625'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C2... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
In silico evolutionary analysis of Helicobacter pylori outer membrane phospholipase A (OMPLA). | BACKGROUND: In the past decade, researchers have proposed that the pldA gene for outer membrane phospholipase A (OMPLA) is important for bacterial colonization of the human gastric ventricle. Several conserved Helicobacter pylori genes have distinct genotypes in different parts of the world, biogeographic patterns that... | ['Bacterial Outer Membrane Proteins', 'Computational Biology', 'Evolution, Molecular', 'Helicobacter pylori', 'Molecular Sequence Data', 'Phospholipases A1', 'Phylogeny', 'Sequence Analysis, DNA'] | 22,974,200 | [['D12.776.097.120', 'D12.776.543.100'], ['H01.158.273.180', 'L01.313.124'], ['G05.045.250', 'G16.075.250'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['L01.453.245.667'], ['D08.811.277.352.100.680.750.875'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.760.700']] | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Extractive spectrophotometric determination of some anti-inflammatory agents with methylene violet. | A fairly sensitive spectrophotometric method for the determination of ibuprofen, ketoprofen, piroxicam, diclofenac sodium, mefenamic acid or enfenamic acid in bulk samples and pharmaceutical preparations is described, based on the formation of a chloroform-soluble, coloured ion-association complex between the drug and ... | ['Anti-Inflammatory Agents, Non-Steroidal', 'Chemical Phenomena', 'Chemistry', 'Phenothiazines', 'Spectrophotometry, Atomic'] | 2,757,224 | [['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['G02'], ['H01.181'], ['D02.886.369', 'D03.633.300.783'], ['E05.196.712.726.551', 'E05.196.867.826.551']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
High Concentration of Sodium Metasilicate Impairs Autophagic Flux and Induces Apoptosis in Human Umbilical Vein Endothelial Cells. | Silicon-doped materials have been widely used in bone regeneration research; however, a consensus on the safety range of silicon ions has not been reached and its toxicity mechanism remains to be further elucidated. This study aims to explore whether high level of sodium metasilicate can induce toxicity effect in human... | ['Apoptosis', 'Apoptosis Regulatory Proteins', 'Autophagic Cell Death', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Silicates'] | 30,600,495 | [['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['G04.011.500', 'G04.146.954.053'], ['A11.436.275.682'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.578.725', 'D01.837.725.700.760']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Methyl parathion-induced sperm shape abnormalities in mouse. | Metacid 50, the commercial grade of methyl parathion (O,O-dimethyl-O-4-nitrophenyl phosphorothionate), a commonly used organophosphorus insecticide, was tested for its genotoxicity in Swiss albino mice using the sperm abnormality assay. Sperms of albino mice were examined at two time intervals, 1 week and 5 weeks after... | ['Animals', 'Body Weight', 'Dose-Response Relationship, Drug', 'Male', 'Methyl Parathion', 'Mice', 'Mice, Inbred Strains', 'Mutagens', 'Reference Values', 'Spermatozoa'] | 1,381,479 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.705.400.625.600.500', 'D02.705.539.345.600.500', 'D02.886.300.692.600.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. | We conducted a 1000 Genomes-imputed genome-wide association study (GWAS) meta-analysis for nicotine dependence, defined by the Fagerstr?m Test for Nicotine Dependence in 17 074 ever smokers from five European-ancestry samples. We followed up novel variants in 7469 ever smokers from five independent European-ancestry sa... | ['European Continental Ancestry Group', 'Female', 'Genetic Predisposition to Disease', 'Genome-Wide Association Study', 'Humans', 'Male', 'Polymorphism, Single Nucleotide', 'RNA Splice Sites', 'Receptors, Nicotinic', 'Tobacco Use Disorder'] | 26,440,539 | [['M01.686.508.400'], ['C23.550.291.687.500', 'G05.380.355'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N06.850.520.470.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795.598'], ['D13.444.735.544.550', 'G02.111.570.080.... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Tolerance of radiotherapy combined with adjuvant chemotherapy in breast cancer. | Forty-three postmenopausal breast cancer patients with axillary lymph node metastasis were randomized to receive postoperative radiotherapy (45 Gy) or the combination of radiotherapy and 6 months of chemotherapy. Forty-three premenopausal patients had postoperative radiotherapy and were randomized to receive one of two... | ['Antineoplastic Combined Chemotherapy Protocols', 'Axilla', 'Breast Neoplasms', 'Combined Modality Therapy', 'Cyclophosphamide', 'Doxorubicin', 'Female', 'Fluorouracil', 'Humans', 'Lymphatic Metastasis', 'Menopause', 'Methotrexate', 'Middle Aged', 'Pulmonary Fibrosis', 'Radiotherapy, High-Energy', 'Random Allocation'] | 3,120,758 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['A01.378.800.090'], ['C04.588.180', 'C17.800.090.500'], ['E02.186'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['D03.383.742.698.875.404'], ['B01.050.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Erratum to "IL8 and serum soluble TRAIL levels following anti-VEGF monoclonal antibody treatment in patients with metastatic colon cancer" [Clin. Lab. 2012; 58:501-505]. | BACKGROUND: Colorectal cancer is the third most common human cancer and the third leading cause of cancer related death. BevacizumAb is a humanized monoclonal antibody developed against vascular endothelial growth factor (VEGF) for the treatment of metastatic cancers. Our goal was to evaluate the possibility of using s... | ['Adenocarcinoma', 'Angiogenesis Inhibitors', 'Antibodies, Monoclonal, Humanized', 'Bevacizumab', 'Biomarkers, Tumor', 'Colonic Neoplasms', 'Female', 'Humans', 'Interleukin-8', 'Male', 'Middle Aged', 'Prognosis', 'Survival Rate', 'TNF-Related Apoptosis-Inducing Ligand', 'Vascular Endothelial Growth Factor A'] | 23,163,132 | [['C04.557.470.200.025'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['D12.776.124.486.485.114.224.060.375', 'D12.776.124.790.651.114.224.060.438', 'D12.776.377.715.548.114.224.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Neonatal cutaneous hematopoiesis disclosing congenital rubella]. | INTRODUCTION: Congenital rubella, which should disappear with widespread vaccination and mandatory obstetrical care, can occur as a purpuric eruption in the newborn. We report a case of blueberry muffin baby.CASE REPORT: An infant delivered after an "uneventful" pregnancy presented a generalized "purpuric" eruption and... | ['Diagnosis, Differential', 'Hematopoiesis', 'Humans', 'Infant, Newborn', 'Male', 'Rubella Syndrome, Congenital', 'Skin Diseases, Viral'] | 8,761,088 | [['E01.171'], ['G04.152.825', 'G09.188.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C01.925.782.930.700.700.700', 'C16.131.077.790'], ['C01.925.825', 'C17.800.838.790']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A physiological model for tert-amyl methyl ether and tert-amyl alcohol: hypothesis testing of model structures. | The oxygenate tert-amyl methyl ether (TAME) is a gasoline fuel additive used to reduce carbon monoxide in automobile emissions. To evaluate the relative health risk of TAME as a gasoline additive, information is needed on its pharmacokinetics and toxicity. The objective of this study was to use a physiologically-based ... | ['Administration, Inhalation', 'Animals', 'Glucuronates', 'Liver', 'Male', 'Models, Biological', 'Pentanols', 'Protein Binding', 'Rats', 'Rats, Inbred F344', 'Statistics as Topic', 'Time Factors', 'Tosylarginine Methyl Ester'] | 10,367,338 | [['E02.319.267.050'], ['B01.050'], ['D02.241.081.844.915.162', 'D02.241.152.811.162', 'D02.241.511.902.915.162', 'D09.811.922.162'], ['A03.620'], ['E05.599.395'], ['D02.033.415.640', 'D10.289.640'], ['G02.111.679', 'G03.808'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.200', 'B01.050.150.900... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
The Association Between Retinal Neuronal Layer and Brain Structure is Disrupted in Patients with Cognitive Impairment and Alzheimer's Disease. | Both healthy and pathological aging due to Alzheimer's disease (AD) are associated with decreased brain grey matter volume (GMV) and disrupted white matter (WM) microstructure. Thinner macular ganglion cell-inner plexiform layer (GC-IPL) measured by spectral-domain optical coherence tomography has been reported in pati... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Brain', 'Cognitive Dysfunction', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Retinal Ganglion Cells', 'Retinal Neurons'] | 27,567,815 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['A08.186.211'], ['F03.615.250.700'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.711.513'], ['A08.675.650.850.875', 'A09.371.729.831.875', 'A11.671.650.850.875'], ['A08.675.650.... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Retrieval of morphine-associated context induces cFos in dentate gyrus neurons. | Addiction has been proposed to emerge from associations between the drug and the reward-associated contexts. This associative learning has a cellular correlate, as there are more cFos+ neurons in the hippocampal dentate gyrus (DG) after psychostimulant conditioned place preference (CPP) versus saline controls. However,... | ['Analysis of Variance', 'Animals', 'Conditioning, Operant', 'Dentate Gyrus', 'Gene Expression Regulation', 'Mental Recall', 'Mice', 'Morphine', 'Narcotics', 'Neurons', 'Proto-Oncogene Proteins c-fos', 'Time Factors'] | 25,424,867 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['F02.463.425.179.509'], ['A08.186.211.180.405.200', 'A08.186.211.200.885.287.500.345.200'], ['G05.308'], ['F02.463.425.540.641'], ['B01.050.150.900.649.313.992.635.505.500'], ['D03.132.577.249.562.571', 'D03.605.497.607.587', 'D03.633.400... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model. | The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco-Apc1638N (B6) and A/JCrIBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the ApcMin mod... | ['Adenomatous Polyposis Coli', 'Animals', 'Epidermal Cyst', 'Female', 'Fibromatosis, Aggressive', 'Gastrointestinal Neoplasms', 'Genetic Predisposition to Disease', 'Loss of Heterozygosity', 'Male', 'Mammary Neoplasms, Animal', 'Mice', 'Mice, Inbred A', 'Mice, Inbred BALB C', 'Mice, Inbred C3H', 'Mice, Inbred C57BL', '... | 10,451,698 | [['C04.557.470.035.215.100', 'C04.588.274.476.411.307.089', 'C04.700.100', 'C06.301.371.411.307.090', 'C06.405.249.411.307.090', 'C06.405.469.158.356.090', 'C06.405.469.491.307.090', 'C06.405.469.578.249', 'C16.320.700.100'], ['B01.050'], ['C04.182.254'], ['C04.557.450.565.590.340.410'], ['C04.588.274.476', 'C06.301.37... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing. | Recent studies suggest that dementia in the most elderly (90 years of age and above) is only modestly related to Alzheimer's disease pathology. This raises the possibility that other, as yet unknown, disease processes may underlie dementia in this rapidly growing demographic group, and that efforts designed to combat A... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Baltimore', 'Brain', 'Dementia', 'Female', 'Humans', 'Intracranial Arteriosclerosis', 'Longitudinal Studies', 'Male', 'Neurofibrillary Tangles', 'Plaque, Amyloid', 'Prevalence', 'Prospective Studies', 'Risk', 'Severity of Illness Index'] | 20,647,264 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['Z01.107.567.875.500.500.100', 'Z01.433.100'], ['A08.186.211'], ['C10.228.140.380', 'F03.615.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.51... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Further studies by Christoph Scheiner concerning the optics of the eye. | The physician, mathematician and astronomer was born in 1573 in Wald near Mindelheim in Swabia, Germany. He died in 1650 in Neisse in Silesia. He discovered the sun spots and also dealt with the physiological optics of the eye. Further observations of Scheiner's are represented, i.e. from his books Oculus and Rosa Ursi... | ['Eye', 'Germany', 'History, 16th Century', 'History, 17th Century', 'Humans', 'Ophthalmology', 'Optics and Photonics', 'Vision, Ocular'] | 7,995,230 | [['A01.456.505.420', 'A09.371'], ['Z01.542.315'], ['K01.400.475.750'], ['K01.400.504.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.810.468'], ['H01.671.617', 'J01.293.688'], ['F02.830.816.964', 'G02.111.820.480.900', 'G04.835.480.900', 'G11.561.790.964', 'G14.935']] | ['Anatomy [A]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 |
Mismatch repair in the antimutator Escherichia coli mud. | Antimutators are genetic mutants that produce mutations at reduced rates compared to the wild type strain. They are interesting because they may provide insights into the mechanisms by which spontaneous mutations occur. We have investigated a reported antimutator strain of Escherichia coli termed mud for its possible m... | ['Bacteriophage lambda', 'Base Pair Mismatch', 'DNA Repair', 'Escherichia coli', 'Genetic Vectors', 'Mutation', 'Transformation, Genetic'] | 12,517,409 | [['B04.123.150.800.230', 'B04.123.205.230', 'B04.280.090.800.230'], ['G05.365.590.060'], ['G02.111.222', 'G05.219'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.337'], ['G05.365.590'], ['G05.728.865']] | ['Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of oral sodium polyacrylate in rat gastrointestinal alkali burns. | Alkali-induced injuries of the esophagus and stomach are currently medically managed with steroids and antibiotics. We investigated whether treatment with sodium polyacrylate (PANa), a proposed mucosal protectant, could decrease the deleterious effect of alkali injuries or prevent alkali injuries. Rats were randomized ... | ['Acrylic Resins', 'Animals', 'Burns, Chemical', 'Digestive System', 'Gastric Mucosa', 'Male', 'Rats', 'Rats, Inbred Strains', 'Sodium Hydroxide'] | 3,381,486 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['B01.050'], ['C26.200.156'], ['A03'], ['A03.556.875.875.440', 'A10.615.550.291'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['D01.045.250.750', 'D01.248.497.158... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
NKCC1 does not accumulate chloride in developing retinal neurons. | GABA excites immature neurons due to their relatively high intracellular chloride concentration. This initial high concentration is commonly attributed to the ubiquitous chloride cotransporter NKCC1, which uses a sodium gradient to accumulate chloride. Here we tested this hypothesis in immature retinal amacrine and gan... | ['Age Factors', 'Animals', 'Animals, Newborn', 'Bumetanide', 'Calcium', 'Chlorides', 'Drug Interactions', 'Gene Expression Regulation, Developmental', 'Mice', 'Mice, Knockout', 'Nerve Tissue Proteins', 'Neurons', 'Retina', 'Sodium Potassium Chloride Symporter Inhibitors', 'Sodium-Potassium-Chloride Symporters', 'Solute... | 17,493,914 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['B01.050.050.282'], ['D02.065.884.150', 'D02.241.223.100.050.300.200', 'D02.455.426.559.389.127.020.452.500', 'D02.886.590.700.150'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D01.210.450.150', 'D01.248.497.158.215'], ['G07.690.773.968'], ['G05.308.3... | ['Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Transcatheter mitral valve implantation via transapical approach: an early experience. | OBJECTIVES: As many as 50% of patients with severe symptomatic mitral valve regurgitation are denied surgical valve replacement or repair due to high operative risk. We describe an early series of cases of transcatheter implantation with a CardiAQ™ mitral valve via a transapical approach.METHODS: Three consecutive pati... | ['Aged', 'Aged, 80 and over', 'Female', 'Heart Valve Prosthesis', 'Heart Valve Prosthesis Implantation', 'Humans', 'Male', 'Mitral Valve', 'Mitral Valve Insufficiency', 'Treatment Outcome'] | 25,653,251 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.695.310'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.541.510.507'], ['C14.280.484.461'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Preservation of biochemical liver function with low-dose soy-based lipids in children with intestinal failure-associated liver disease. | OBJECTIVES: Intestinal failure-associated liver disease (IFALD) contributes to significant morbidity in pediatric patients with intestinal failure (IF); however, the use of parenteral nutrition (PN) with a fish oil-based intravenous (IV) emulsion (FO) has been associated with biochemical reversal of cholestasis and imp... | ['Bilirubin', 'Boston', 'Child Development', 'Cholestasis', 'Compassionate Use Trials', 'Fat Emulsions, Intravenous', 'Fish Oils', 'Follow-Up Studies', 'Hepatic Insufficiency', 'Hospitals, Pediatric', 'Humans', 'Infant', 'Infant Nutrition Disorders', 'Infant Nutritional Physiological Phenomena', 'Liver', 'Malabsorption... | 25,714,580 | [['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['Z01.107.567.875.550.510.210', 'Z01.433.210'], ['F01.525.200', 'G07.345.374.750'], ['C06.130.120.135'], ['E02.931.500', 'E05.290.250.199', 'E05.337.300.199'], ['D26.255.165.260.270', 'D26.776.708.733.500', 'D27.505.9... | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Family ethics in caring for newborns with impairments. | The technological advances of modern society mean that family members have expanded obligations to care for newborns with severe impairments, who would have died in previous eras. This biological imbalance has created a moral one as well, for to care is to be penalized. Often this moral heroism can be sustained as a va... | ['Congenital Abnormalities', 'Ethics', 'Family', 'Female', 'Home Nursing', 'Humans', 'Infant', 'Infant, Newborn', 'Infant, Newborn, Diseases', 'Male', 'Marriage', 'Moral Obligations', 'Morals', 'Personhood', 'Social Justice', 'Social Responsibility'] | 10,282,297 | [['C16.131'], ['K01.752.566.479', 'N05.350'], ['F01.829.263', 'I01.880.853.150'], ['E02.760.611.470', 'N02.421.143.524.470', 'N02.421.533.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C16.614'], ['F01.829.263.315.500.500', 'I01.240.361.500.500', 'I01.880.853.150.423.500... | ['Diseases [C]', 'Humanities [K]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Mouse model for abortive rabies infection of the central nervous system. | When adult mice were injected by the footpad route with the attenuated rabies virus ERA/BHK, serum- and brain-associated antibody and interferon were produced, nonspecific cytotoxic cells and virus-specific cytolytic T cells in the spleen were activated, and a nonlethal infection of the central nervous system occurred.... | ['Animals', 'Antibodies, Viral', 'B-Lymphocytes', 'Central Nervous System Diseases', 'Cyclophosphamide', 'Disease Models, Animal', 'Immunosuppression', 'Interferons', 'Mice', 'Mice, Inbred A', 'Mice, Nude', 'Rabies', 'Rabies virus', 'T-Lymphocytes'] | 6,163,717 | [['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['C10.228'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['C22.232', 'E05.598.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fractal analysis of mammographic lesions: a prospective, blinded trial. | Mammography has become the mainstay of breast cancer screening. However, widespread mammography has led to an increase of the number of breast biopsies done for benign disease. Therefore, a method to better discriminate benign from malignant lesions is needed. Fractal analysis is a mathematical method which can quantif... | ['Analysis of Variance', 'Breast Neoplasms', 'Carcinoma in Situ', 'Carcinoma, Ductal, Breast', 'Data Interpretation, Statistical', 'Female', 'Fibroadenoma', 'Fibrocystic Breast Disease', 'Fractals', 'Humans', 'Mammography', 'Prospective Studies', 'ROC Curve', 'Sensitivity and Specificity', 'Single-Blind Method'] | 9,776,508 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.240'], ['C04.557.470.200.025.232.500', 'C04.557.470.615.132.500', 'C04.588.180.390', 'C17.800.090.500.390'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Learning new gait patterns is enhanced by specificity of training rather than progression of task difficulty. | The use of motor learning strategies may enhance rehabilitation outcomes of individuals with neurological injuries (e.g., stroke or cerebral palsy). A common strategy to facilitate learning of challenging tasks is to use sequential progression - i.e., initially reduce task difficulty and slowly increase task difficulty... | ['Adult', 'Biomechanical Phenomena', 'Feedback, Sensory', 'Female', 'Gait', 'Humans', 'Learning', 'Male', 'Middle Aged', 'Rehabilitation'] | 30,905,405 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['F04.754.137.301.500', 'F04.754.308.500.500', 'F04.754.339', 'G07.410.732.500'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['M01.060.116.630'], ['E02.760.169.063.500', 'E02.831',... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Skin permeability of various non-steroidal anti-inflammatory drugs in man. | The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic rel... | ['Absorption', 'Administration, Topical', 'Anti-Inflammatory Agents', 'Humans', 'Kinetics', 'Salicylates', 'Skin'] | 3,747,720 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['E02.319.267.120'], ['D27.505.954.158'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D02.241.223.100.300.595', 'D02.241.511.390.595', 'D02.455.426.559.389.127.281.595', 'D02.455.426.559.389.657.410.595'], ['A17... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. | Human skin is exposed daily to solar ultraviolet (UV) radiation. UV induces the matrix metalloproteinases collagenase, 92-kD gelatinase, and stromelysin, which degrade skin connective tissue and may contribute to premature skin aging (photoaging). Pretreatment of skin with all-trans retinoic acid (tRA) inhibits UV indu... | ['Activating Transcription Factor 2', 'Antineoplastic Agents', 'Calcium-Calmodulin-Dependent Protein Kinases', 'Cyclic AMP Response Element-Binding Protein', 'ErbB Receptors', 'Gene Expression', 'Humans', 'JNK Mitogen-Activated Protein Kinases', 'Mitogen-Activated Protein Kinases', 'Nerve Tissue Proteins', 'Promoter Re... | 9,502,786 | [['D12.776.260.108.061.750', 'D12.776.930.127.061.750'], ['D27.505.954.248'], ['D08.811.913.696.620.682.700.125', 'D12.644.360.100', 'D12.776.476.100'], ['D12.776.260.108.184', 'D12.776.930.127.184'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['G05.297'], ['B01.0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Influence of nitrogen depletion in the growth of N. oleoabundans on the release of cellular components after beadmilling. | Cell disruption by bead milling of Neochloris oleoabundans grown under nitrogen repleted (NR) and nitrogen depleted (ND) conditions was evaluated based on the release of biochemicals and biomass to the supernatant. Additionally, energy consumption for cell disruption was calculated per kg of released component. Bead mi... | ['Biomass', 'Biotechnology', 'Chlorophyta', 'Energy Metabolism', 'Lipid Metabolism', 'Lipids', 'Microalgae', 'Nitrogen', 'Proteins'] | 27,128,193 | [['G16.500.275.157.100', 'N06.230.124.100'], ['H01.158.550', 'J01.897.120'], ['B01.650.940.150'], ['G03.295'], ['G03.458'], ['D10'], ['B05.080.500.600.500'], ['D01.268.604', 'D01.362.625'], ['D12.776']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Which is important for preschoolers' production and repair of statements: what the listener knows or what the listener says? | Three- and four-year-olds participated in a referential communication task wherein they requested stickers from a knowledgeable or ignorant adult to complete a card. Following inadequate initial requests children were provided with three different feedback types: goal substitution (i.e. an incorrect sticker was provide... | ['Child Language', 'Child, Preschool', 'Communication', 'Cues', 'Feedback, Psychological', 'Female', 'Humans', 'Language Development', 'Male', 'Psychology, Child'] | 22,152,344 | [['F01.525.200.310.250'], ['M01.060.406.448'], ['F01.145.209', 'L01.143'], ['F02.463.425.234'], ['F01.058.288', 'F04.754.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.525.200.310'], ['F04.096.628.193']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
CE-MRA of the lower extremities using HYPR stack-of-stars. | PURPOSE: To investigate the properties of HYPR (HighlY constrained back PRojection) processing-the temporal fidelity and the improvements of spatial/temporal resolution-for contrast-enhanced MR angiography in a pilot study of the lower extremities in healthy volunteers.MATERIALS AND METHODS: HYPR processing with a radi... | ['Artifacts', 'Contrast Media', 'Humans', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Leg', 'Magnetic Resonance Angiography', 'Pilot Projects'] | 19,306,427 | [['E05.047'], ['D27.505.259.500', 'D27.720.259'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.400', 'L01.224.308.410'], ['A01.378.610.500'], ['E01.370.350.825.500.500', 'E01.370.370.050.500'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Apoptosis and impaired axonal regeneration of sensory neurons after nerve crush in diabetic rats. | We investigated the possible induction of apoptosis of dorsal root ganglion (DRG) neurons and the defect of nerve regeneration after crush injury with reference to the JNK/c-jun and cAMP pathway in streptozocin-induced diabetic rats. In addition, the effects of a PGE1 analogue were tested in diabetic rats. At day 0 (be... | ['Afferent Pathways', 'Alprostadil', 'Animals', 'Apoptosis', 'Axons', 'Carrier Proteins', 'Cyclic AMP', 'Diabetes Mellitus, Experimental', 'Diabetic Neuropathies', 'Disease Models, Animal', 'Ganglia, Spinal', 'Immunohistochemistry', 'In Situ Nick-End Labeling', 'Male', 'Nerve Crush', 'Nerve Regeneration', 'Phosphorylat... | 10,757,497 | [['A08.612.220'], ['D10.251.355.255.550.250.100', 'D10.251.355.325.050', 'D23.469.050.175.725.250.100'], ['B01.050'], ['G04.146.954.035'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['D12.776.157'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Trends and opportunities in geropsychiatric nursing: enhancing practice through specialization and interprofessional education. | Forecasted changes in the demographics of the United States suggest there will be an unprecedented need for health care professionals with specific training in geropsychiatric care. An aging society, the dearth of geropsychiatric health care professionals, the shortage of educators, and the lack of interprofessional ge... | ['Aged', 'Competency-Based Education', 'Education, Nursing', 'Geriatric Nursing', 'Humans', 'Interdisciplinary Studies', 'Patient Care Team', 'Program Development', 'Psychiatric Nursing', 'United States'] | 23,656,377 | [['M01.060.116.100'], ['I02.158.210'], ['I02.358.462'], ['H02.478.676.236', 'N02.421.533.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.158.405'], ['N04.590.715'], ['N04.452.760'], ['H02.478.676.710', 'N02.421.533.778'], ['Z01.107.567.875']] | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Muscle-pair specific distribution and grip-type modulation of neural common input to extrinsic digit flexors. | To gain insight into the synergistic control of hand muscles, we have recently quantified the strength of correlated neural activity across motor units from extrinsic digit flexors during a five-digit object-hold task. We found stronger synchrony and coherence across motor units from thumb and index finger flexor muscl... | ['Adult', 'Female', 'Fingers', 'Hand', 'Hand Strength', 'Humans', 'Male', 'Motor Activity', 'Muscle, Skeletal'] | 16,723,414 | [['M01.060.116'], ['A01.378.800.667.430'], ['A01.378.800.667'], ['E01.370.600.425.500', 'G11.427.560.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.632', 'G11.427.410.698'], ['A02.633.567', 'A10.690.552.500']] | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2. | The regulation of PLD2 activation is poorly understood at present. Transient transfection of COS-7 with a mycPLD2 construct results in elevated levels of PLD2 enzymatic activity and tyrosyl phosphorylation. To investigate whether this phosphorylation affects PLD2 enzymatic activity, anti-myc immunoprecipitates were tre... | ['Adaptor Proteins, Signal Transducing', 'Animals', 'COS Cells', 'Chlorocebus aethiops', 'Dose-Response Relationship, Drug', 'GRB2 Adaptor Protein', 'Gene Expression Regulation', 'Multiprotein Complexes', 'Phospholipase D', 'Protein Binding', 'Protein Tyrosine Phosphatase, Non-Receptor Type 1', 'Protein Tyrosine Phosph... | 15,896,299 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['A11.251.210.172.500', 'A11.329.228.220'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['G07.690.773.875', 'G07.690.936.500'], ['D12.644.360.024.290', 'D12.776.157.057.041', 'D12.776.476.024.377'], ['G05.308'], ['D05.500'], ['D08.811... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bovine tendons. Aging and collagen cross-linking. | The level of cross-linking between the polypeptide chains of the collagen molecules in bovine tendons of different ages has been assessed by measuring quantitatively through densitometry the changes in the ratios of individual cyanogen bromide peptides separated on polyacrylamide gels. An increase in the number of cros... | ['Aging', 'Animals', 'Animals, Newborn', 'Cattle', 'Collagen', 'Macromolecular Substances', 'Peptide Fragments', 'Tendons'] | 670,217 | [['G07.345.124'], ['B01.050'], ['B01.050.050.282'], ['B01.050.150.900.649.313.500.380.271'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D05'], ['D12.644.541'], ['A02.880']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Usefulness of magnetic resonance spectroscopy for diagnosis of hepatic encephalopathy in a patient with relapsing confusional syndrome. | Magnetic resonance spectroscopy allows the assessment of several metabolites in brain tissue. In patients with hepatic encephalopathy, this technique shows a rise in glutamine and a decrease in myoinositol in brain tissue. However, the role of magnetic resonance spectroscopy in the diagnosis of hepatic encephalopathy i... | ['Biopsy', 'Brain', 'Confusion', 'Diagnosis, Differential', 'Female', 'Hepatic Encephalopathy', 'Humans', 'Liver', 'Liver Cirrhosis', 'Magnetic Resonance Spectroscopy', 'Middle Aged', 'Recurrence'] | 11,713,951 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['A08.186.211'], ['C10.597.606.337', 'C23.888.592.604.339', 'F01.700.250'], ['E01.171'], ['C06.552.308.500.356', 'C10.228.140.163.360', 'C18.452.132.360'], ['B01.050.150.900.64... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population-based cohort study in Sweden. | AIMS: Type 1 diabetes mellitus (T1DM) is an autoimmune disease with potential mechanistic links to immune-related cancers. We aimed at examining the overall and specific cancer risks among hospitalized T1DM patients from the national registers in Sweden.METHODS: A T1DM research cohort was created by identifying T1DM pa... | ['Adolescent', 'Age Distribution', 'Carcinoma, Squamous Cell', 'Cohort Studies', 'Diabetes Mellitus, Type 1', 'Female', 'Hospitalization', 'Humans', 'Incidence', 'Leukemia', 'Male', 'Medical Record Linkage', 'Neoplasms', 'Risk Factors', 'Skin Neoplasms', 'Stomach Neoplasms', 'Sweden'] | 20,636,960 | [['M01.060.057'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Human phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomas. | Cancer cells reorganize their metabolic pathways to fuel demanding rates of proliferation. Oftentimes, these metabolic phenotypes lie downstream of prominent oncogenes. The lipid signaling molecule phosphatidic acid (PtdOH), which is produced by the hydrolytic enzyme phospholipase D (PLD), has been identified as a crit... | ['Amino Acid Sequence', 'Brain Neoplasms', 'Cell Line, Tumor', 'Enzyme Inhibitors', 'Glioma', 'Humans', 'Molecular Sequence Data', 'Phospholipase D', 'Pyrimidines', 'Signal Transduction', 'Structure-Activity Relationship', 'TOR Serine-Threonine Kinases'] | 25,646,564 | [['G02.111.570.060', 'L01.453.245.667.060'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['A11.251.210.190', 'A11.251.860.180'], ['D27.505.519.389'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Influence of parental gender and self-reported health and illness on parent-reported child health. | BACKGROUND: Although there is clear evidence of the influence of parental factors on child health outcomes, the influence of parental perceptions of their health and illness on the reporting of child health remains primarily unknown.OBJECTIVES: To examine relationships between parents' reporting of their own health and... | ['Adolescent', 'Adult', 'Attitude to Health', 'Australia', 'Chi-Square Distribution', 'Child', 'Child Welfare', 'Child, Preschool', 'Confounding Factors, Epidemiologic', 'Data Collection', 'Female', 'Health Status', 'Humans', 'Logistic Models', 'Male', 'Parents', 'Population Surveillance', 'Sex Factors', 'Surveys and Q... | 11,099,598 | [['M01.060.057'], ['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['Z01.639.100', 'Z01.678.100.373'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['M01.060.406'], ['I01.880.787.293'], ['M01.060.406.448'], ['N05.715.350.240', 'N06.850.490.718'], ['E05.318.308', 'L01.399... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
The influence of fibrillin-1 and physical activity upon tendon tissue morphology and mechanical properties in mice. | Fibrillin-1 mutations cause pathological changes in connective tissue that constitute the complex phenotype of Marfan syndrome. In this study, we used fibrillin-1 hypomorphic and haploinsufficient mice (Fbn1mgr/mgR and Fbn1+/- mice, respectively) to investigate the impact of fibrillin-1 deficiency alone or in combinati... | ['Animals', 'Biomechanical Phenomena', 'Fibrillin-1', 'Male', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Physical Conditioning, Animal', 'Tendons'] | 31,724,332 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['D09.400.430.875.500', 'D12.776.395.341.500', 'D12.776.860.300.400.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['G11.427.410.698.277.280'], ['A02.880']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
How do acetabular version and femoral head coverage change with skeletal maturity? | BACKGROUND: Normal changes in acetabular version over the course of skeletal development have not been well characterized. Knowledge of normal version development is important because acetabular retroversion has been implicated in several pathologic hip processes.QUESTIONS/PURPOSES: The purpose of this study was to cha... | ['Acetabulum', 'Adolescent', 'Child', 'Female', 'Femur Head', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Osteogenesis', 'Reference Values', 'Retrospective Studies', 'Tomography, X-Ray Computed'] | 25,344,405 | [['A02.835.232.043.825.108'], ['M01.060.057'], ['M01.060.406'], ['A02.835.232.043.150.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['G07.345.500.325.377.625.050.500.729', 'G11.427.578.050.500.729'], ['E05.978.810'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.... | ['Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Kinetic study employing UV derivative spectroscopy of DM-COOK, antitumor and antimetastatic agent. | The hydrolysis of p-(3,3-dimethyl-l-triazeno)benzoic acid potassium salt (1;DM-COOK) a highly active antimetastatic and anti-disseminative agent, has been studied in buffered aqueous solution over a pH range of 2.8-8.8 degrees C. The pH dependence of the pseudo first-order rate constants showed two different routes. Un... | ['Chemical Phenomena', 'Chemistry', 'Hydrogen-Ion Concentration', 'Kinetics', 'Spectrophotometry, Ultraviolet', 'Temperature', 'Triazenes'] | 2,402,528 | [['G02'], ['H01.181'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['D02.925']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. | CONTEXT: Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure. Previous studies have not had adequate statistical power to measure the effects of exercise training on clinical outcomes.OBJECTIVE: To test the efficacy and safety of exercise training among patients... | ['Aged', 'Ambulatory Care', 'Chronic Disease', 'Exercise', 'Exercise Therapy', 'Female', 'Heart Failure', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Quality of Life', 'Self Care'] | 19,351,941 | [['M01.060.116.100'], ['E02.760.106', 'N02.421.585.106'], ['C23.550.291.500'], ['G11.427.410.698.277', 'I03.350'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['C14.280.434'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['I01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Crystal structure of the anticoagulant slow form of thrombin. | Using the thrombin mutant R77aA devoid of the site of autoproteolytic degradation at exosite I, we have solved for the first time the structure of thrombin free of any inhibitors and effector molecules and stabilized in the Na(+)-free slow form. The slow form shows subtle differences compared with the currently availab... | ['Anticoagulants', 'Crystallography', 'Humans', 'Hydrogen Bonding', 'Hydrolysis', 'Models, Molecular', 'Mutagenesis, Site-Directed', 'Protein Conformation', 'Substrate Specificity', 'Thrombin'] | 12,205,081 | [['D27.505.954.502.119'], ['E05.196.309', 'H01.181.529.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.282'], ['G02.380'], ['E05.599.595'], ['E05.393.420.601.575'], ['G02.111.570.820.709'], ['G02.111.835'], ['D08.811.277.656.300.760.855', 'D08.811.277.656.959.350.855', 'D12.776.124.125.890', 'D23.119.960'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Muscarinic acetylcholine receptor immunoreactivity in the amygdala--I. Cellular distribution correlated with fear-induced behavior. | This study examined the distribution of muscarinic acetylcholine receptor-immunoreactive neurons in the amygdaloid complex of the rat, with emphasis on the central nucleus. The monoclonal antibody M35 raised against purified muscarinic acetylcholine receptor protein was used to visualize muscarinic acetylcholine recept... | ['Amygdala', 'Animals', 'Behavior, Animal', 'Fear', 'Immunohistochemistry', 'Male', 'Neurons', 'Rats', 'Rats, Wistar', 'Receptors, Muscarinic'] | 8,971,759 | [['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['B01.050'], ['F01.145.113'], ['F01.470.361'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', ... | ['Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Maternal performance differences between porcine stress syndrome-normal and -carrier Landrace females. | Differences between porcine stress syndrome (PSS) normal (NN) and carrier (Nn) Landrace dams were determined for adjusted number of pigs born alive, adjusted number of pigs at 21 d, adjusted 21-d litter weight, proportion of pigs surviving to 21 d, and farrowing interval. Data were analyzed from a total of 841 females,... | ['Alleles', 'Animals', 'Breeding', 'Female', 'Gene Frequency', 'Heterozygote', 'Phenotype', 'Reproduction', 'Stress, Physiological', 'Swine', 'Swine Diseases', 'Syndrome'] | 9,419,983 | [['G05.360.340.024.340.030'], ['B01.050'], ['E05.820.150', 'G05.090'], ['G05.330'], ['G05.380.383'], ['G05.695'], ['G08.686.784'], ['G07.775'], ['B01.050.150.900.649.313.500.880'], ['C22.905'], ['C23.550.288.500']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Semisynthesis of libiguin A and its analogues by trans-lactonization of phragmalin. | Libiguins are limonoids with highly potent sexual activity enhancing effects, originally isolated from the Madagascarian Meliaceae species Neobeguea mahafalensis, where they exist in only minute quantities. Their low natural abundance has hampered mapping of their biological effects. Here we describe an approach to the... | ['Limonins', 'Meliaceae', 'Molecular Conformation'] | 24,716,657 | [['D02.455.849.919.490'], ['B01.650.940.800.575.912.250.715'], ['G02.111.570.820']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Notch signaling is required for the maintenance of enteric neural crest progenitors. | Notch signaling is involved in neurogenesis, including that of the peripheral nervous system as derived from neural crest cells (NCCs). However, it remains unclear which step is regulated by this signaling. To address this question, we took advantage of the Cre-loxP system to specifically eliminate the protein O-fucosy... | ['Animals', 'Apoptosis', 'Cell Count', 'Cell Differentiation', 'Cell Lineage', 'Cell Movement', 'Cell Proliferation', 'Embryo, Mammalian', 'Enteric Nervous System', 'Fucosyltransferases', 'Gene Expression Regulation, Developmental', 'Gene Targeting', 'Ligands', 'Mice', 'Mice, Knockout', 'Models, Biological', 'Neural Cr... | 18,832,397 | [['B01.050'], ['G04.146.954.035'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.152'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['A16.254'], ['A08.800.050.150'], ['D08.811.913.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The socially enriched environment in early age alters the exploratory activity and ability for learning in rats]. | The effects of socially enriched environment on exploration activity in early age and avoidance learning in adult rats were studied. Rats reared in enriched environment were housed with mother and three young rats before weaning. Control rats were housed with mother only. An increase in exporation activity in the open-... | ['Animals', 'Animals, Suckling', 'Avoidance Learning', 'Exploratory Behavior', 'Female', 'Learning', 'Maze Learning', 'Rats', 'Rats, Wistar', 'Social Environment'] | 10,984,911 | [['B01.050'], ['B01.050.050.293'], ['F02.463.425.097', 'F02.463.785.373.173'], ['F01.145.387', 'F01.658.370'], ['F02.463.425', 'F02.784.629.529'], ['F02.463.425.874.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['I01.880.853.500']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Diaper dermatitis: a therapeutic dilemma. Results of a double-blind placebo controlled trial of miconazole nitrate 0.25%. | Diaper dermatitis, an acute inflammation of the skin in the diaper area, is the most common dermatologic disorder of infancy. This placebo-controlled, randomized, double-blind, parallel-group trial compared the efficacy and safety of miconazole nitrate 0.25% in a zinc oxide/petrolatum base with that of the ointment bas... | ['Antifungal Agents', 'Candida albicans', 'Candidiasis', 'Conjunctivitis', 'Diaper Rash', 'Double-Blind Method', 'Female', 'Fever', 'Humans', 'Infant', 'Male', 'Miconazole', 'Patient Dropouts', 'Severity of Illness Index', 'Skin', 'Time Factors', 'Treatment Outcome', 'Vomiting'] | 11,358,560 | [['D27.505.954.122.136'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['C01.150.703.160'], ['C11.187.183'], ['C17.800.174.255.400.250', 'C17.800.815.255.400.250'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['C23.888.119.344'], ['B01.050.150.900.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effects of sodium, hydrogen and magnesium ions on mitochondrial calcium sequestration in adult rat ventricular myocytes. | The effect of Na+, H+ and Mg2+ ions on net calcium exchange induced in digitonin-treated myocytes has been investigated. Raising the [Na] from 1.4 to 31.4 mM revealed a sodium-sensitive fraction of net calcium exchange with a K1/2 for Na+ ions of 12 mM, alongside the respiration-dependent accumulation of calcium. An ac... | ['Animals', 'Biological Transport', 'Calcium', 'Digitonin', 'Heart Ventricles', 'Hydrogen-Ion Concentration', 'Magnesium', 'Mitochondria, Heart', 'Myocardium', 'Rats', 'Sodium'] | 6,151,662 | [['B01.050'], ['G03.143'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D04.210.500.155.580.130.500.236', 'D09.408.180.261.236'], ['A07.541.560'], ['G02.300'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['A11.284.430.214.190.875.564.627.603', 'A11.284.835.626.627.603'], ['A02.633.580', 'A07.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Melatonin protects primary cultures of rat cortical neurones from NMDA excitotoxicity and hypoxia/reoxygenation. | Studies on rat cortical cultures show that glutamate (10 microM) or hypoxia followed by reoxygenation causes damage to the cells as indexed by a release of lactate dehydrogenase (LDH). These effects could be counteracted by the N-methyl-D-aspartate (NMDA) antagonist MK-801 (2 microM) but not by the kainate/AMPA antagon... | ['6-Cyano-7-nitroquinoxaline-2,3-dione', 'Animals', 'Cells, Cultured', 'Cerebral Cortex', 'Excitatory Amino Acid Antagonists', 'Hypoxia, Brain', 'L-Lactate Dehydrogenase', 'Melatonin', 'N-Methylaspartate', 'Neurons', 'Neuroprotective Agents', 'Oxygen', 'Rats', 'Reactive Oxygen Species'] | 9,369,308 | [['D03.633.100.857.160'], ['B01.050'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['C10.228.140.624', 'C23.888.852.079.797'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['D03.633.100.473.914.481', 'D06.472.506'], ['D12.125.067.500.400', 'D12.125.11... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Plasmapheresis in the treatment of hyperthyroidism associated with agranulocytosis: A case report. | Plasmapheresis, also known as therapeutic plasma exchange, is used in the treatment of several disorders. Temporary improvement after plasmapheresis in cases with thyrotoxicosis has been reported. A 55-year-old woman presented with agranulocytosis induced by propylthiouracil and clinical signs of heart failure. Three s... | ['Agranulocytosis', 'Antithyroid Agents', 'Female', 'Humans', 'Hyperthyroidism', 'Middle Aged', 'Plasmapheresis', 'Propylthiouracil'] | 15,493,048 | [['C15.378.553.546.184'], ['D06.347.100', 'D27.505.696.399.450.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.874.397'], ['M01.060.116.630'], ['E02.120.770', 'E02.912.715', 'E04.292.869'], ['D03.383.742.698.875.842.708']] | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Symptomatic Rathke's cleft cysts; clinical and therapeutic data. | The authors report on a case of symptomatic Rathke's Cleft Cyst (RCC). The only clinical feature was headache. The cystic fluid was aspirated through a trans-sphenoidal approach. The postoperative course was uneventful. The rarity of symptomatic RCC (70 cases described in the literature; 30 operated patients) makes nec... | ['Adult', 'Craniopharyngioma', 'Female', 'Humans', 'Pituitary Gland', 'Pituitary Neoplasms', 'Tomography, X-Ray Computed'] | 3,347,332 | [['M01.060.116'], ['C04.557.465.625.200', 'C04.557.580.625.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A06.300.747', 'A06.688.357.750', 'A08.186.211.180.497.352.435.500', 'A08.186.211.200.317.357.352.435.500', 'A08.713.357.750'], ['C04.588.322.609', 'C04.588.614.250.195.885.500.600', 'C10.228.140.211.885.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Racial variation in antidepressant treatment in a Medicaid population. | BACKGROUND: Many studies have found racial and socioeconomic variation in medical care for a variety of conditions. Undertreatment of depression for individuals of all races is a concern, but especially may affect vulnerable populations such as Medicaid recipients and minorities. With this study, we examine racial diff... | ['Adult', 'African Americans', 'Aid to Families with Dependent Children', 'Antidepressive Agents', 'Delivery of Health Care', 'Depressive Disorder', 'Drug Prescriptions', 'Drug Utilization', 'European Continental Ancestry Group', 'Female', 'Health Policy', 'Humans', 'Male', 'Medicaid', 'Regression Analysis', 'Serotonin... | 10,695,640 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['N03.219.521.346.506.849.095'], ['D27.505.954.427.700.122'], ['N04.590.374', 'N05.300'], ['F03.600.300'], ['E02.319.307', 'N02.421.668.778.500'], ['N04.452.706.477'], ['M01.686.508.400'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.4... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Woman with virilizing congenital adrenal hyperplasia and Leydig cell tumor of the ovary. | We report the case of a 36-year-old woman with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, and corticosteroid replacement therapy since birth. She manifested persistent virilization and high testosterone levels that were attributed to nonadherence to medical treatment. The patient was referre... | ['Adrenal Hyperplasia, Congenital', 'Adult', 'Female', 'Humans', 'Leydig Cell Tumor', 'Ovarian Neoplasms', 'Virilism'] | 24,702,195 | [['C12.706.316.090.500', 'C13.351.875.253.090.500', 'C16.131.939.316.129.500', 'C16.320.033', 'C16.320.565.925.249', 'C18.452.648.925.249', 'C19.053.440', 'C19.391.119.090.500'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.475.750.847.249', 'C04.588.322.762.500.249', 'C04.588.945.440.915... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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