Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Sustained atrial tachycardia in adult patients. Electrophysiological characteristics, pharmacological response, possible mechanisms, and effects of radiofrequency ablation. | BACKGROUND: Mechanisms and electropharmacological characteristics in adult patients with atrial tachycardia (AT) are not well described. We proposed that a combination of electropharmacological characteristics, recording of monophasic action potential, and effects of radiofrequency ablation could further determine the ... | ['Adult', 'Aged', 'Cardiac Pacing, Artificial', 'Catheter Ablation', 'Electrophysiology', 'Female', 'Heart Atria', 'Humans', 'Male', 'Middle Aged', 'Tachycardia, Supraventricular'] | 8,087,935 | [['M01.060.116'], ['M01.060.116.100'], ['E02.331.200'], ['E02.808.750.500', 'E04.014.760.500'], ['H01.158.344.528', 'H01.158.782.236'], ['A07.541.358'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.067.845.880', 'C14.280.123.875.880', 'C23.550.073.845.880']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
A systematic approach to evaluation of the rearfoot, ankle, and leg in reconstructive surgery. | The current literature shows that proper alignment of the lower extremity allows for greater function throughout the gait cycle. Therefore, realignment should be one of the primary goals in the surgical management of lower-extremity deformities and pathology. Multiplanar radiographic angular relationships should be cri... | ['Ankle', 'Ankle Joint', 'Biomechanical Phenomena', 'Bone Malalignment', 'Foot Deformities', 'Foot Joints', 'Heel', 'Humans', 'Leg', 'Lower Extremity', 'Preoperative Care', 'Radiography', 'Reconstructive Surgical Procedures'] | 15,659,408 | [['A01.378.610.050'], ['A02.835.583.378.062'], ['G01.154.090', 'G01.374.089'], ['C05.116.214'], ['C05.330'], ['A02.835.583.378'], ['A01.378.610.250.510'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['A01.378.610'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['E01.370.350.700'], ['E04.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bodily embarrassment and judgment concern as separable factors in the measurement of medical embarrassment: psychometric development and links to treatment-seeking outcomes. | OBJECTIVES: Understanding why people do not always engage in medical examinations that might benefit them is a public health issue which is receiving increased attention. One area of promise involves the study of medical embarrassment, although current studies are weakened in that they measure medical embarrassment in ... | ['Adult', 'Attitude to Health', 'Body Image', 'Female', 'Humans', 'Judgment', 'Male', 'Patient Acceptance of Health Care', 'Psychology', 'Psychometrics', 'Shame', 'Surveys and Questionnaires', 'Treatment Outcome'] | 17,640,455 | [['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['F01.752.747.792.110', 'F02.463.593.112'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.785.626'], ['F01.100.150.750.500', 'F01.145.488.887.500', 'N05.300.150.800.500'], ['F04.096.628'], ['F04.711.780'], ['F01.470.483.666'], ['E05.318.308.980', 'N05.715.3... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Purification and molecular cloning of cDNA for an inducible antibacterial protein of larvae of a coleopteran insect, Holotrichia diomphalia. | Injection of Escherichia coli into larvae of the coleopteran Holotrichia diomphalia results in the appearance of antibacterial activity in the hemolymph. An antibacterial protein, named holotricin 2, was purified from larvae of this insect and characterized. A cDNA clone for holotricin 2 was isolated and its complete s... | ['Amino Acid Sequence', 'Animals', 'Anti-Bacterial Agents', 'Bacteria', 'Base Sequence', 'Chromatography, High Pressure Liquid', 'Cloning, Molecular', 'Coleoptera', 'DNA, Complementary', 'Hemolymph', 'Insect Hormones', 'Insect Proteins', 'Larva', 'Molecular Sequence Data'] | 8,188,641 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D27.505.954.122.085'], ['B03'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.181.400.300'], ['E05.393.220'], ['B01.050.500.131.617.720.500.500.375'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['A13.4... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Functional recovery and axonal growth following spinal cord transection is accelerated by sustained L-DOPA administration. | The eel, Anguilla anguilla, as with other fish species, recovers well from spinal cord injury. We assessed the quality of locomotion of spinally transected eels from measurements made from video recordings of individuals swimming at different speeds in a water tunnel. Following transection of the spinal cord just cauda... | ['Anguilla', 'Animals', 'Axons', 'Growth Cones', 'Levodopa', 'Motor Activity', 'Recovery of Function', 'Spinal Cord Injuries'] | 15,450,079 | [['B01.050.150.900.493.338.282'], ['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A11.284.180.075.249', 'A11.284.180.225.340', 'A11.284.180.610.345', 'A11.671.137.340', 'A11.671.240.340'], ['D02.092.311.200.480', 'D02.455.426.559.389.657.166.175.200.480', 'D12.125.072.050.685.40... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Captopril in congestive heart failure: improved left ventricular function with decreased metabolic cost. | The oral angiotensin-converting enzyme inhibitor captopril (CPT) produces beneficial hemodynamic and clinical responses in patients with chronic congestive heart failure (CHF). Cardiac output and stroke volume increase, along with a decrease in pulmonary capillary wedge pressure, indicating improved left ventricular fu... | ['Angiotensin-Converting Enzyme Inhibitors', 'Captopril', 'Heart Failure', 'Heart Ventricles', 'Hemodynamics', 'Humans', 'Hydralazine', 'Hypotension', 'Myocardium', 'Oxygen Consumption', 'Prazosin', 'Proline', 'Vasodilator Agents'] | 6,291,359 | [['D27.505.519.389.745.085'], ['D12.125.072.401.623.270'], ['C14.280.434'], ['A07.541.560'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.710.605.500'], ['C14.907.514'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['G03.680'], ['D03.633.100.786.750'], ['D12.125.072.401.623'], ['D27... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chondrosarcomatous cutaneous metastasis. A unique manifestation of sarcomatoid (metaplastic) breast carcinoma. | Breast carcinoma is the most common origin of cutaneous metastasis in women but is usually of ductal or lobular histotypes. Sarcomatoid (metaplastic) carcinoma of the breast, although a well-established aggressive neoplasm, is very uncommon. The metaplastic elements span all types of mesenchymal differentiation and hav... | ['Aged', 'Breast Neoplasms', 'Female', 'Humans', 'Metaplasia', 'Sarcoma', 'Skin Neoplasms'] | 8,902,102 | [['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.589'], ['C04.557.450.795'], ['C04.588.805', 'C17.800.882']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Thoracoscopy versus thoracotomy: a prospective comparison of trauma and quality of life. | BACKGROUND: Reliable comparisons of thoracoscopy (TCC) and anterolateral thoracotomy (ATT) with regard to trauma and post-operative quality of life are rare. This study was conducted to quantify the results of TCC, which was expected to show an advantage.METHODS: Using a matched-pair design (matching criteria: comparab... | ['Female', 'Humans', 'Male', 'Prospective Studies', 'Quality of Life', 'Thoracoscopy', 'Thoracotomy'] | 11,981,682 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E01.370.388.250.840', 'E04.502.250.840', 'E04.928.752'], ['E04.928.760']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Biomaterial scaffolds in cartilage-subchondral bone defects influencing the repair of autologous articular cartilage transplants. | The repair of articular cartilage typically involves the repair of cartilage-subchondral bone tissue defects. Although various bioactive materials have been used to repair bone defects, how these bioactive materials in subchondral bone defects influence the repair of autologous cartilage transplant remains unclear. The... | ['Alkaline Phosphatase', 'Animals', 'Biocompatible Materials', 'Biomechanical Phenomena', 'Bone Substitutes', 'Cartilage, Articular', 'Hyaline Cartilage', 'Hydroxyapatites', 'Lactic Acid', 'Materials Testing', 'Polyglycolic Acid', 'Polylactic Acid-Polyglycolic Acid Copolymer', 'Sheep', 'Tissue Scaffolds', 'Transplantat... | 22,684,516 | [['D08.811.277.352.650.035'], ['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['G01.154.090', 'G01.374.089'], ['D25.130.325', 'J01.637.051.130.325'], ['A02.165.407.150', 'A02.835.583.192'], ['A02.165.407', 'A10.165.382.400'], ['D01.029.260.700.675.374.075.025.300', 'D01.146.360.050.300', 'D01.578.122.47... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Seeing the forest through the trees: a comparison of different IAT variants measuring implicit alcohol associations. | Dual-process models propose that addictive behaviors are determined by an implicit, impulsive system and an explicit, reflective system. Consistent with these models, research has demonstrated implicit affective associations with alcohol, using the Implicit Association Test (IAT), that predict unique variance in drinki... | ['Affect', 'Alcoholism', 'Behavior, Addictive', 'Bipolar Disorder', 'Emotions', 'Genetic Association Studies', 'Genetic Variation', 'Humans', 'Reproducibility of Results', 'Surveys and Questionnaires'] | 19,781,863 | [['F01.470.047'], ['C25.775.100.250', 'F03.900.100.350'], ['F01.145.527.100.120'], ['F03.084.500'], ['F01.470'], ['E05.393.385'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.308.980', 'N05.715.360.300.800', 'N0... | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Application of recurrent neural network for online prediction of cell density of recombinant Pichia pastoris producing HBsAg. | Artificial neural networking (ANN) seems to be a promising soft sensor for implementing current approaches of quality by design (QbD) and process analytical technologies (PAT) in the biopharmaceutical industry. In this study, we aimed to implement best-fitted ANN architecture for online prediction of the biomass amount... | ['Bacterial Load', 'Biomass', 'Bioreactors', 'Fermentation', 'Hepatitis B Surface Antigens', 'Hepatitis B virus', 'Methanol', 'Neural Networks, Computer', 'Pichia', 'Recombinant Proteins'] | 30,707,051 | [['E01.370.225.875.150.115', 'E01.370.225.875.220.115', 'E05.200.875.150.115', 'E05.200.875.220.115', 'G06.099.100'], ['G16.500.275.157.100', 'N06.230.124.100'], ['E07.115', 'J01.897.120.115'], ['G02.111.158.249', 'G03.191.249'], ['D23.050.327.495.500.475'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['D02.033.623... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Hepatic arterial infusion enhances DOTATOC radiopeptide therapy in patients with neuroendocrine liver metastases. | Intravenously administered radiolabeled peptides targeting somatostatin receptors are used for the treatment of unresectable gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Recently, we demonstrated a high first-pass effect during intra-arterial (i.a.) administration of positron emission tomography (PET) label... | ['Adult', 'Aged', 'Chromogranin A', 'Female', 'Hepatic Artery', 'Humans', 'Infusions, Intra-Arterial', 'Liver Neoplasms', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neuroendocrine Tumors', 'Octreotide', 'Pancreatic Neoplasms', 'Pilot Projects', 'Positron-Emission Tomography', 'Radiopharmaceuticals', 'Tomogra... | 21,791,571 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.631.199.249'], ['A07.015.114.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.510.520'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C04.557.465.625.650', 'C04.557.580.625.650'], ['D04.345.566.65... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Williamsia spongiae sp. nov., an actinomycete isolated from the marine sponge Amphimedon viridis. | A novel actinobacterium, designated isolate B138T, was isolated from the marine sponge, Amphimedon viridis, which was collected from Praia Guaec? (S?o Paulo, Brazil), and its taxonomic position was established using data from a polyphasic study. The organism showed a combination of chemotaxonomic and morphological char... | ['Actinomycetales', 'Animals', 'Bacterial Typing Techniques', 'Base Composition', 'Brazil', 'DNA, Bacterial', 'Nucleic Acid Hybridization', 'Phylogeny', 'Porifera', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA'] | 28,100,308 | [['B03.510.024.049'], ['B01.050'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['G02.111.080'], ['Z01.107.757.176'], ['D13.444.308.212'], ['E05.393.661', 'G02.111.611'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B01.050.500.802'], ['D13.444.735.686.670'], ['E05.393.760.700']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model. | Familial dysautonomia (FD) is a severe neurodegenerative genetic disorder restricted to the Ashkenazi Jewish population. The most common mutation in FD patients is a T-to-C transition at position 6 of intron 20 of the IKBKAP gene. This mutation causes aberrant skipping of exon 20 in a tissue-specific manner, leading to... | ['Alternative Splicing', 'Animals', 'Carrier Proteins', 'Cell Line', 'Disease Models, Animal', 'Dysautonomia, Familial', 'Exons', 'Female', 'Gene Knock-In Techniques', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Introns', 'Male', 'Mice', 'Mice, Transgenic', 'Phosphatidylserines', 'Transcriptional Elonga... | 23,515,154 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['B01.050'], ['D12.776.157'], ['A11.251.210'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C10.177.575.300', 'C10.500.250.309', 'C10.574.500.493.250', 'C10.668.829.800.175.250', 'C16.131.666.310.309', 'C16.320.400.415.309'], ['G05.360.340.024.340.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Growth of non-phototrophic microorganisms using solar energy through mineral photocatalysis. | Phototrophy and chemotrophy are two dominant modes of microbial metabolism. To date, non-phototrophic microorganisms have been excluded from the solar light-centered phototrophic metabolism. Here we report a pathway that demonstrates a role of light in non-phototrophic microbial activity. In lab simulations, visible li... | ['Acidithiobacillus', 'Alcaligenes faecalis', 'Bacteria', 'Bioelectric Energy Sources', 'Biomass', 'Minerals', 'Phototrophic Processes', 'Solar Energy', 'Sunlight'] | 22,473,012 | [['B03.440.400.425.103', 'B03.660.250.015'], ['B03.440.400.425.115.050.200', 'B03.660.075.090.344.050.200'], ['B03'], ['E07.305.124.150'], ['G16.500.275.157.100', 'N06.230.124.100'], ['D01.578'], ['G02.111.669', 'G03.800'], ['G01.750.897', 'N06.230.132.644.500'], ['G01.358.500.505.650.836', 'G01.750.250.650.836', 'G01.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hepatic glycogen depletion in fed female rats induced by piroxicam. | The effects of i.p. piroxicam administration on hepatic glycogen levels and enzymatic activities of key enzymes involved into glycogen metabolism in fed female rats were studied. Liver glycogen concentrations in treated rats decreased with increasing time of treatment and doses of piroxicam administered. The fall in gl... | ['Animals', 'Body Weight', 'Female', 'Glucose-6-Phosphatase', 'Glycogen Synthase', 'Liver Glycogen', 'Nadolol', 'Phenobarbital', 'Phosphorylases', 'Piroxicam', 'Rats', 'Rats, Wistar'] | 1,338,186 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D08.811.277.352.650.225'], ['D08.811.913.400.450.460.375'], ['D05.750.078.562.388.518', 'D09.698.365.388.518'], ['D02.033.100.624.698.601', 'D02.033.755.624.698.601', 'D02.092.063.624.698... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Laser capsulorrhaphy for multidirectional instability of the shoulder. An outcomes study and proposed classification system. | BACKGROUND: Clinical data on the efficacy of laser capsulorrhaphy for the treatment of multidirectional instability of the shoulder are limited.HYPOTHESIS: The diagnosis of multidirectional instability includes a spectrum of pathologic symptoms that warrants subclassification; laser capsulorrhaphy alone is not uniforml... | ['Adolescent', 'Adult', 'Chi-Square Distribution', 'Female', 'Humans', 'Joint Capsule', 'Joint Dislocations', 'Joint Instability', 'Laser Therapy', 'Logistic Models', 'Male', 'Pain', 'Patient Satisfaction', 'Recovery of Function', 'Recurrence', 'Reoperation', 'Retrospective Studies', 'Risk Factors', 'Shoulder Joint', '... | 12,531,753 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.443'], ['C05.550.518', 'C26.289'], ['C05.550.521'], ['E02.594', 'E04.014.520'], ['E05.318.740.500.525', 'E05.318.740.600.800.450... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
A cautionary note concerning the use of stabilized weights in marginal structural models. | Marginal structural models are commonly used to estimate the causal effect of a time-varying treatment in presence of time-dependent confounding. When fitting an MSM to data, the analyst must specify both the structural model for the outcome and the treatment models for the inverse-probability-of-treatment weights. The... | ['Bias', 'Biostatistics', 'Blood Pressure', 'Causality', 'Computer Simulation', 'Confounding Factors, Epidemiologic', 'Humans', 'Models, Statistical', 'Motor Activity', 'Observational Studies as Topic'] | 25,410,264 | [['N05.715.350.150', 'N06.850.490.500'], ['E05.318.740.237'], ['E01.370.600.875.249', 'G09.330.380.076'], ['N05.715.350.200', 'N06.850.490.625'], ['L01.224.160'], ['N05.715.350.240', 'N06.850.490.718'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.5... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Molecular imaging of reductive coupling reactions: interstitial-mediated coupling of benzaldehyde on reduced TiO2(110). | We report the first visualization of a reactive intermediate formed from coupling two molecules on a surface-a diolate formed from benzaldehyde coupling on TiO(2)(110). The diolate, imaged using scanning tunneling microscopy (STM), is reduced to gaseous stilbene upon heating to ?400 K, leaving behind two oxygen atoms t... | ['Adsorption', 'Benzaldehydes', 'Feasibility Studies', 'Microscopy, Scanning Tunneling', 'Models, Molecular', 'Molecular Conformation', 'Nanostructures', 'Oxidation-Reduction', 'Surface Properties', 'Temperature', 'Titanium'] | 21,229,961 | [['G01.030', 'G02.020'], ['D02.047.222'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E01.370.350.515.666.500', 'E05.595.666.500'], ['E05.599.595'], ['G02.111.570.820'], ['J01.637.512'], ['G02.700', 'G03.295.531'], ['G02.860'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Adverse effects of chromium oxide nano-particles on seed germination and growth in Triticum aestivum L. | In this study, seeds of Triticum aestivum L. (Poaceae) were exposed to 0-100 microg/mL chromium oxide nanoparticles (Cr2O3, Nps) to study the phytotoxic effects on seed germination and seedling growth. It has been observed that 25-100 microg/mL Cr2O3, Nps inhibited the seed germination and seedling growth in concentrat... | ['Chromium Compounds', 'Dose-Response Relationship, Drug', 'Germination', 'Nanoparticles', 'Seeds', 'Triticum'] | 21,485,872 | [['D01.220'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.345.625.249', 'G15.357'], ['J01.637.512.600'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500.775'], ['B01.650.940.800.575.912.250.822.918']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. | PURPOSE: To identify novel therapeutic opportunities for patients with prostate cancer, we applied high-throughput screening to systematically explore most currently marketed drugs and drug-like molecules for their efficacy against a panel of prostate cancer cells.EXPERIMENTAL DESIGN: We carried out a high-throughput c... | ['Animals', 'Antineoplastic Agents', 'Carcinoma', 'Cell Proliferation', 'Cells, Cultured', 'Disulfiram', 'Drug Screening Assays, Antitumor', 'High-Throughput Screening Assays', 'Humans', 'Male', 'Mice', 'Mice, Nude', 'Models, Biological', 'Prostatic Neoplasms', 'Small Molecule Libraries', 'Xenograft Model Antitumor Ass... | 19,789,329 | [['B01.050'], ['D27.505.954.248'], ['C04.557.470.200'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D02.241.081.251.869.220.250', 'D02.886.520.150.175', 'D02.886.706.200.200'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['E05.916.680'], ['B01.050.150.900.649.313.988.400.112... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of the protein kinase C inhibitor H-7 and calmodulin antagonist W-7 on superoxide production in growing and resting human histiocytic leukemia cells (U937). | Serum, phorbol 12,13-didecanoate (PDD) and 1-oleoyl-2-acetoy-sn-glycerol (OAG) stimulated O2- release in human histiocytic leukemia U937 cells. The kinetics of O2- release caused by PDD but not by serum or OAG in growing cells differed from those in resting cells. Both the protein kinase C inhibitor 1-(5-isoquinolinyls... | ['1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine', 'Calmodulin', 'Cell Division', 'Cell Line', 'Humans', 'Isoquinolines', 'Kinetics', 'Leukemia, Myeloid', 'Piperazines', 'Protein Kinase C', 'Sulfonamides', 'Superoxides'] | 3,034,277 | [['D02.886.590.700.545', 'D03.383.606.527', 'D03.633.100.531.400'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.531'], ['G01.374.661', ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Deblurring. | In most instances, traditional EEG methodology provides insufficient spatial detail to identify relationships between brain electrical events and structures and functions visualized by magnetic resonance imaging or positron emission tomography. This article describes a method called Deblurring for increasing the spatia... | ['Brain', 'Cognition', 'Electroencephalography', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Memory', 'Mental Processes', 'Pattern Recognition, Visual', 'Reading'] | 10,426,404 | [['A08.186.211'], ['F02.463.188'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['F02.463.425.540'], ['F02.463'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['L01.559.423.557']] | ['Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Retinal oxidation, apoptosis and age- and sex-differences in the mnd mutant mouse, a model of neuronal ceroid lipofuscinosis. | Retinal degeneration is an early and progressive event in many forms of neuronal ceroid lipofuscinoses (NCLs), a heterogeneous group of neurodegenerative disorders with unknown pathogenesis. We here used the mutant motor neuron degeneration (mnd) mouse, a late-infantile NCL variant, to investigate the retinal oxidative... | ['Aldehydes', 'Animals', 'Apoptosis', 'Caspase 3', 'Caspases', 'Disease Models, Animal', 'Enzyme Activation', 'Female', 'Immunohistochemistry', 'In Situ Nick-End Labeling', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Neurologic Mutants', 'Neuronal Ceroid-Lipofuscinoses', 'Oxidation-Reduction', 'Oxidative Stress', 'Ret... | 15,213,005 | [['D02.047'], ['B01.050'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['C22.232', 'E05.598... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Healing the schism: medicine and public health in Pakistan. | BACKGROUND: The relationship between medicine and public health has a long and complex co-evolution. In developing countries where the health needs are greatest and resources are few, this relationship is of critical importance.DEVELOPMENT OF MEDICINE AND PUBLIC HEALTH AT THE AGA KHAN UNIVERSITY: This paper provides a ... | ['Community Medicine', 'Delivery of Health Care', 'Education, Medical', 'Health Services Needs and Demand', 'Humans', 'Pakistan', 'Public Health'] | 19,034,838 | [['H02.403.220'], ['N04.590.374', 'N05.300'], ['I02.358.399'], ['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.723'], ['H02.403.720', 'N01.400.550', 'N06.850']] | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Predicting neuropsychological abnormalities in multiple sclerosis. | Multiple Sclerosis (MS) is associated with MRI signal alteration and neuropsychological (NP) dysfunction. Screening tools have been developed to identify patients at high risk for these neurological complications of MS. One such measure, the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ), has well... | ['Adult', 'Analysis of Variance', 'Cognition Disorders', 'Disability Evaluation', 'Female', 'Follow-Up Studies', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Multiple Sclerosis', 'Neuropsychological Tests', 'Predictive Value of Tests', 'Psychiatric Status Rating Scales', 'Reproducibility of Results',... | 16,626,751 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F03.615.250'], ['E01.370.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C10.114.375.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Role of ultrasound biomicroscopy in management of eyes with stage 5 retinopathy of prematurity. | BACKGROUND AND OBJECTIVE: To assess the role of ultrasound biomicroscopy in the surgical management of eyes with stage 5 retinopathy of prematurity.PATIENTS AND METHODS: Ultrasound biomicroscopy was performed preoperatively in 18 eyes with stage 5 retinopathy of prematurity to view the access to the anterior surgical s... | ['Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Microscopy, Acoustic', 'Monitoring, Intraoperative', 'Preoperative Period', 'Prospective Studies', 'Reproducibility of Results', 'Retinopathy of Prematurity', 'Severity of Illness Index', 'Vitrectomy'] | 20,307,037 | [['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E01.370.350.515.370', 'E01.370.350.850.565', 'E05.595.370'], ['E01.370.520.510', 'E04.510'], ['E04.614.937', 'N02.421.585.753.937'], ['E05.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Functional analysis of the defective T cell regulation of the antigen-specific PFC response in SLE patients: differentiation of suppressor precursor cells to suppressor effector cells. | The investigation described here is concerned with the T cell regulation of the antigen-specific antibody response which has been studied in patients suffering from systemic lupus erythematosus (SLE). Apart from the fact that T helper cell activity was found to be less efficient, it appeared that the peripheral blood l... | ['Antibodies, Monoclonal', 'Antibody Formation', 'Antibody Specificity', 'Hemolytic Plaque Technique', 'Humans', 'Lupus Erythematosus, Systemic', 'Ovalbumin', 'Phenotype', 'T-Lymphocytes, Regulatory'] | 6,210,474 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G12.450.050.370.250'], ['G12.100'], ['E01.370.225.812.375', 'E05.200.812.375', 'E05.478.594.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.300.480', 'C20.111.590'], ['D12.644.861.557', 'D12.776.034.614', 'D1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhanced sonochemical decomposition of 1,4-dioxane by ferrous iron. | The enhanced ultrasonic decomposition of 1,4-dioxane by the addition of ferrous iron (Fe(II)) was investigated at 205, 358, 618, and 1071 kHz. The total organic carbon (TOC) remaining was also determined at each frequency. Addition of Fe(II) improved the 1,4-dioxane decomposition rate and mineralization efficiency at a... | ['Dioxanes', 'Hydroxyl Radical', 'Iron', 'Oxidants', 'Oxidation-Reduction', 'Ultrasonics', 'Water Purification'] | 12,727,247 | [['D03.383.188'], ['D01.045.250.357', 'D01.248.497.158.459.300', 'D01.339.431.249'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D27.720.642', 'D27.888.569.540'], ['G02.700', 'G03.295.531'], ['H01.671.031.849'], ['N06.850.780.200.800.800.900.900', 'N06.850.860.510.900.900']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Circulating prostacyclin and thromboxane levels in patients with diabetic retinopathy. | Prostacyclin (PGI2) is the most potent endogenous inhibitor of platelet aggregation yet discovered. Thromboxane (TXA2) promotes aggregation and degranulation of platelets. It is hypothesized that an homeostasis exists between these pathways that is protective against vascular damage and is disturbed in several diseases... | ['Diabetic Retinopathy', 'Epoprostenol', 'Humans', 'Male', 'Middle Aged', 'Prostaglandins', 'Thromboxane A2', 'Thromboxanes'] | 6,750,495 | [['C11.768.257', 'C14.907.320.382', 'C19.246.099.500.382'], ['D10.251.355.255.550.550.500', 'D23.469.050.175.725.550.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D10.251.355.255.550', 'D23.469.050.175.725'], ['D10.251.355.255.100.825.800', 'D10.251.355.310.166.971.800'], ['D10.251.355.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The Tsukuba hypertensive mouse (transgenic mouse carrying human genes for both renin and angiotensinogen) as a model of human malignant hypertension: development of lesions and morphometric analysis. | The renin-angiotensin system has a pivotal role in hypertension. The Tsukuba hypertensive mouse (THM; a transgenic mouse carrying human genes for both renin and angiotensinogen) was generated to allow further examination of the renin-angiotensin system in a variety of pathologic conditions. We evaluated the development... | ['Animals', 'Arteritis', 'Blood Pressure', 'Disease Models, Animal', 'Endothelium', 'Female', 'Glomerulosclerosis, Focal Segmental', 'Humans', 'Hypertension', 'Juxtaglomerular Apparatus', 'Kidney Glomerulus', 'Male', 'Mice', 'Mice, Transgenic', 'Muscle, Smooth, Vascular', 'Renin-Angiotensin System'] | 9,504,863 | [['B01.050'], ['C14.907.940.090'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A10.272.491'], ['C12.777.419.570.363.660', 'C13.351.968.419.570.363.640'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['A05.810.453.324.359.520', 'A05.810.453.736.520.52... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Financial Toxicity of Cancer Care: It's Time to Intervene. | Evidence suggests that a considerably large proportion of cancer patients are affected by treatment-related financial harm. As medical debt grows for some with cancer, the downstream effects can be catastrophic, with a recent study suggesting a link between extreme financial distress and worse mortality. At least three... | ['Communication', 'Cost-Benefit Analysis', 'Health Care Costs', 'Health Expenditures', 'Health Literacy', 'Humans', 'Insurance Coverage', 'Insurance, Health', 'Medicare', 'Neoplasms', 'Quality of Life', 'Stress, Psychological', 'United States'] | 26,657,334 | [['F01.145.209', 'L01.143'], ['N03.219.151.125'], ['N03.219.151.400', 'N05.300.375'], ['N03.219.151.450', 'N05.300.385'], ['I02.233.332.186.500', 'L01.143.450.500', 'N02.421.726.407.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.265'], ['N03.219.521.576.343'], ['N03.219.521.346.506.564.66... | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Significance of MTG8 in leukemogenesis. | MTG8 is a counterpart gene of AML1 in acute myeloid leukemia with t(8:21) translocation. Most of the coding region of the MTG8 is fused with AML1 runt domain. In normal tissues, the MTG8 is highly expressed in brain, but not in hematopoietic tissues. MTG8 may be important in leukemogenesis as well as in AML1 truncation... | ['Acute Disease', 'Brain', 'Cell Line', 'Chromosome Mapping', 'Chromosomes, Human, Pair 21', 'Chromosomes, Human, Pair 8', 'Core Binding Factor Alpha 2 Subunit', 'DNA-Binding Proteins', 'Humans', 'Leukemia', 'Leukemia, Myeloid', 'Organ Specificity', 'Proto-Oncogene Proteins', 'RUNX1 Translocation Partner 1 Protein', 'T... | 9,209,371 | [['C23.550.291.125'], ['A08.186.211'], ['A11.251.210'], ['E05.393.183'], ['A11.284.187.520.300.505.510', 'G05.360.162.520.300.505.510'], ['A11.284.187.520.300.325.340', 'G05.360.162.520.300.325.340'], ['D12.776.930.155.200.200'], ['D12.776.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337'], ['C04.5... | ['Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biliary leak in a child after liver transplant and value of delayed images. | A 2-year-old child underwent liver transplant and was referred for postsurgical abdominal pain. Hepatobiliary scintigraphy with Tc-99m iminodiacetic acid (IDA) was performed and with the help of 24-hour delayed images, the diagnosis of biliary leak at the site of anastomosis was made possible. This case report confirms... | ['Bile Duct Diseases', 'Child, Preschool', 'Diagnosis, Differential', 'Humans', 'Liver Transplantation', 'Postoperative Complications', 'Radionuclide Imaging', 'Radiopharmaceuticals', 'Technetium Tc 99m Diethyl-iminodiacetic Acid', 'Ultrasonography'] | 18,097,259 | [['C06.130.120'], ['M01.060.406.448'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['C23.550.767'], ['E01.370.350.710', 'E01.370.384.730'], ['D27.505.259.843', 'D27.505.519.871', 'D27.720.470.410.650'], ['D02.241.081.583.400... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Protein kinase-C in the human fetal adrenal gland. | The fetal zone (FZ) of the human fetal adrenal gland undergoes rapid growth and exhibits a high rate of steroidogenesis throughout fetal life. In addition to cAMP-dependent processes regulating steroidogenesis and possibly growth of the FZ, evidence is accumulating that cAMP-independent mechanisms are also involved. Th... | ['Adrenal Cortex', 'Adrenal Glands', 'Adrenocorticotropic Hormone', 'Chromatography, DEAE-Cellulose', 'Cytosol', 'Electrophoresis, Polyacrylamide Gel', 'Female', 'Fetus', 'Humans', 'Pregnancy', 'Pregnenolone', 'Protein Kinase C', 'Steroids', 'Subcellular Fractions', 'Tetradecanoylphorbol Acetate'] | 2,846,628 | [['A06.300.071.140'], ['A06.300.071'], ['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['E05.196.181.400.383.349'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Membranous structure of purified Escherichia coli lipopolysaccharide. | The ultrastructure of the purified and lyophilized endotoxin from Escherichia coli O111 was observed by ultrathin sectioning. Onion-like globular membrane structures were observed in addition to rod-like and ribbon-like structures, indicating the existence of a globular membrane structure even in the dried state. | ['Acetates', 'Chemical Precipitation', 'Dialysis', 'Endotoxins', 'Escherichia coli', 'Ethanol', 'Freeze Drying', 'Lipopolysaccharides', 'Microscopy, Electron', 'Phenols', 'Polysaccharides, Bacterial', 'Staining and Labeling', 'Uranium', 'Water'] | 4,109,867 | [['D02.241.081.018', 'D10.251.400.045'], ['E05.196.150', 'G02.159'], ['E05.196.353', 'G02.186'], ['D23.946.123.329'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D02.033.375'], ['E01.370.225.500.620.760.160.260', 'E01.370.225.750.600.760.160.260', 'E02.792.156.260', 'E05.200.500.620.760.160.260', 'E05.200... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Arterial indices and serum cystatin C level in individuals with occupational wide band noise exposure. | BACKGROUND: Chronic exposure to noise is known to cause a wide range of health problems including extracellular matrix (ECM) proliferation and involvement of cardiovascular system. There are a few studies to investigate noise-induced vascular changes using noninvasive methods. In this study we used carotid artery intim... | ['Adult', 'Age Factors', 'Aorta', 'Aviation', 'Biomarkers', 'Blood Pressure', 'Carotid Intima-Media Thickness', 'Case-Control Studies', 'Cystatin C', 'Heart Rate', 'Humans', 'Male', 'Middle Aged', 'Noise, Occupational', 'Occupational Exposure', 'Pulse Wave Analysis', 'Risk Factors'] | 27,991,468 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['A07.015.114.056'], ['J01.937.285'], ['D23.101'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.350.850.150', 'E01.370.370.180', 'G09.330.210'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D12.776.215.300'], ['E01.37... | ['Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Treatment decision-making and its relation to the sense of coherence and the meaning of the disease in a group of patients with colorectal cancer. | UNLABELLED: The aims of the present study were to describe the preferred and the actual participating roles in treatment decision-making in relation to patients with newly diagnosed, colorectal cancer and to relate this result to the sociodemographic data, the Sense of Coherence Scale (SOC) and the patients' meaning of... | ['Adult', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Colorectal Neoplasms', 'Female', 'Humans', 'Male', 'Patient Participation', 'Patient Satisfaction'] | 11,881,725 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mesh fixation of the mesentery for treatment of volvulus and recurrent stomal prolapse. | Mesenteric mesh-pexy is indicated for permanent and quick-clean fixation of the intestine. It is applicable to the treatment of recurrent stomal prolapse and intestinal volvulus when the intestine is viable, but resection, less definitive treatment or an additional operation would pose increased risks to the patient. M... | ['Aged', 'Female', 'Humans', 'Intestinal Obstruction', 'Mesentery', 'Methods', 'Pregnancy', 'Prolapse', 'Sigmoid Diseases', 'Surgical Mesh'] | 3,413,656 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.531'], ['A01.923.047.025.600.451'], ['E05.581'], ['G08.686.784.769'], ['C23.300.842'], ['C06.405.469.158.850'], ['E07.858.708']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Evaluation of preoperative complementary examination ordering]. | The ordering of tests is often done in a systematical way. In spite of the studies which have proved that these tests are not useful, and despite the advice of the SFAR (1992) the ordering remains excessive, and is a source of expenses for the population. In that study we have done an evaluation for the ordering of pre... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Cost Control', 'Diagnostic Tests, Routine', 'Female', 'Hospital Costs', 'Hospitals, University', 'Humans', 'Infant', 'Male', 'Medical Audit', 'Middle Aged', 'Practice Guidelines as Topic', "Practice Patterns, Physicians'", 'Preoperative ... | 9,874,593 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['N03.219.151.160'], ['E01.370.395'], ['N03.219.151.400.687', 'N03.219.262.500', 'N05.300.375.500'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Structural features of â-(1?4)-D-galactomannans of plant origin as a probe for â-(1?4)-mannanase polymeric substrate specificity. | Statistical modeling was applied for describing structural features of â-(1?4)-D-galactomannans. According to the model suggested theoretical ratios of limiting degrees of locust bean, tara gum and guar gum galactomannan conversions by two â-(1?4)-mannanases of different origin (Myceliophthora thermophila and Trichoder... | ['Hydrolysis', 'Mannans', 'Plants', 'Sordariales', 'Substrate Specificity', 'Trichoderma', 'beta-Mannosidase'] | 22,436,888 | [['G02.380'], ['D09.698.550'], ['B01.650'], ['B01.300.107.800'], ['G02.111.835'], ['B01.300.381.910'], ['D08.811.277.450.625.750']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Is diagnostic curettage harmful in women with unexplained infertility? | Diagnostic curettage as part of the investigation of the woman with unexplained infertility has not been considered a hazardous procedure. Two similar groups with unexplained primary infertility were examined laparoscopically: 53 patients had undergone diagnostic curettage as part of the investigation; 142 had not. Non... | ['Dilatation and Curettage', 'Female', 'Humans', 'Infertility, Female', 'Laparoscopy', 'Pelvic Inflammatory Disease', 'Pregnancy'] | 6,462,167 | [['E04.157.310', 'E04.950.300.299'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.351.500.365.700'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C01.635.500', 'C13.351.500.056.750'], ['G08.686.784.769']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Steady-state carbamazepine plasma concentration-dose ratios in epileptic patients. | The distribution of carbamazepine plasma concentration-dose ratio was studied in 322 samples from patients undergoing long term treatment. Data have been grouped according to: age--3 to 6, 7 to 9, 10 to 14, and above 15 years old; number of drugs used in the treatment--mono- and polytherapy; dose--less than or equal to... | ['Adolescent', 'Adult', 'Carbamazepine', 'Child', 'Child, Preschool', 'Epilepsy', 'Female', 'Humans', 'Kinetics', 'Male', 'Middle Aged'] | 3,780,114 | [['M01.060.057'], ['M01.060.116'], ['D03.633.300.240.127'], ['M01.060.406'], ['M01.060.406.448'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['M01.060.116.630']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Mentally ill patients: viewed from 2 perspectives. A methodological contribution on attitudinal research in psychiatry]. | The impact of the change in perspective (i.e. the personal opinion of those questioned versus what they perceive the others' opinion toward the mentally ill to be) on the results of the questionnaire is examined based on data from two population surveys measuring attitudes towards the mentally ill. As expected, the res... | ['Attitude to Health', 'Data Interpretation, Statistical', 'Educational Status', 'Germany', 'Humans', 'Mental Disorders', 'Population Surveillance', 'Public Opinion', 'Surveys and Questionnaires'] | 1,604,941 | [['F01.100.150', 'N05.300.150'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['N01.824.196'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['E05.318.308.980.438.700', 'N05.715.360.300.800.438.625', 'N06.850.520.308.980.438.70... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. | In this letter, we describe the first synthesis of two recently isolated flavones 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone (3a), 5-carboethoxymethyl-4',7-dihydroxyflavone (3b) and their derivatives (3c-t), evaluated for their antimicrobial, antioxidant and anticancer activities. Most of the synthesized compounds... | ['Anti-Infective Agents', 'Antifungal Agents', 'Antioxidants', 'Chromones', 'Flavones', 'Flavonoids', 'Microbial Viability', 'Molecular Structure', 'Structure-Activity Relationship'] | 22,677,320 | [['D27.505.954.122'], ['D27.505.954.122.136'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D03.383.663.283.266', 'D03.633.100.150.266'], ['D03.383.663.283.266.450.260', 'D03.633.100.150.266.450.260'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['G06.580'], ['G02.111.570', 'G02.466'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adriamycin in combination chemotherapy of adult acute lymphoblastic leukemia: a Southwest Oncology Group study. | Eighteen (72%) of 25 evaluable and previously untreated patients with adult acute lymphoblastic leukemia entered complete remission (CR) following induction therapy with adriamycin, vincristine, and prednisone in a Southwest Oncology Group study. Remission maintenance therapy with methotrexate and 6-mercaptopurine resu... | ['Adolescent', 'Adult', 'Aged', 'Doxorubicin', 'Drug Evaluation', 'Drug Therapy, Combination', 'Female', 'Humans', 'Leukemia, Lymphoid', 'Male', 'Mercaptopurine', 'Methotrexate', 'Middle Aged', 'Prednisone', 'Remission, Spontaneous', 'Vincristine'] | 284,167 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['E05.290.625', 'E05.337.425'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.428', 'C15.604.515.560', 'C20.683.515.528'], ['D02.886.48... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cerebral oxygen desaturation in patients with totally thoracoscopic ablation for atrial fibrillation: A prospective observational study. | BACKGROUND: Epicardial radiofrequency ablation for stand-alone atrial fibrillation under total video-assisted thoracoscopy has gained popularity in recent years. However, severe cardiopulmonary disturbances during the surgery may affect cerebral perfusion and oxygenation. We therefore hypothesized that regional cerebra... | ['Aged', 'Atrial Fibrillation', 'Catheter Ablation', 'Cerebrovascular Circulation', 'Female', 'Hemodynamics', 'Humans', 'Male', 'Middle Aged', 'Oximetry', 'Oxygen', 'Prospective Studies', 'Spectroscopy, Near-Infrared', 'Thoracic Surgery, Video-Assisted'] | 32,332,606 | [['M01.060.116.100'], ['C14.280.067.198', 'C23.550.073.198'], ['E02.808.750.500', 'E04.014.760.500'], ['G09.330.100.159'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.225.124.100.100.600', 'E01.370.370.380.600', 'E01.370.386.700.100.600', 'E05.200.124.100.100.600'], ... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Key KdSOC1 gene expression profiles during plantlet morphogenesis under hormone, photoperiod, and drought treatments. | Kalanchoe daigremontiana utilizes plantlet formation between its zigzag leaf margins as its method of asexual reproduction. In this study, K. daigremontiana SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (KdSOC1), a key intermediate in the transition from vegetative to asexual growth, was cloned. Furthermore, its expressio... | ['Adaptation, Physiological', 'Amino Acid Sequence', 'Base Sequence', 'Cloning, Molecular', 'Conserved Sequence', 'DNA, Complementary', 'Droughts', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Plant', 'Kalanchoe', 'Light', 'MADS Domain Proteins', 'Molecular Sequence Data', 'Open Reading Fra... | 26,909,971 | [['G07.025', 'G16.012.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['G02.111.570.580'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G16.500.175.781', 'G16.500.750.775.154', 'N06.230.100.230.150'], ['G0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Intramammary defense against infections induced by Escherichia coli in cows. | OBJECTIVE: To examine Escherichia coli lipopolysaccharide (LPS) effects on expression of CD14 and CD18 cell surface receptors and lectin/carbohydrate-mediated nonopsonic phagocytosis of E coli.DESIGN: Cell isolation, monoclonal antibody, phagocytosis, and flow cytometric studies.ANIMALS: 4 clinically normal lactating H... | ['Animals', 'Antibodies, Monoclonal', 'CD18 Antigens', 'Carbohydrates', 'Cattle', 'Escherichia coli', 'Female', 'Flow Cytometry', 'In Vitro Techniques', 'Kinetics', 'Lactation', 'Leukocytes, Mononuclear', 'Lipopolysaccharide Receptors', 'Lipopolysaccharides', 'Mammary Glands, Animal', 'Milk', 'Neutrophils', 'Phagocytos... | 8,712,510 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.395.550.200.275.750', 'D12.776.543.550.200.275.750', 'D12.776.543.750.705.408.200.249', 'D12.776.543.750.705.408.600.100.750', 'D12.776.543.750.705.833.249.750', 'D23.050.301.264.894.118', 'D23.050.301... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
"MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats. | Several chemical compounds found in plant products have proven to possess beneficial properties, being currently pointed out due to their pharmacological potential in type 2 diabetes mellitus complications. In this context, we studied the effect of Geranium robertianum L. (herb Robert) leaf decoctions in Goto-Kakizaki ... | ['Administration, Oral', 'Animals', 'Blood Glucose', 'Diabetes Mellitus, Type 2', 'Disease Models, Animal', 'Geranium', 'Hypoglycemic Agents', 'Male', 'Mitochondria, Liver', 'Oxidative Phosphorylation', 'Plant Extracts', 'Plant Leaves', 'Rats', 'Rats, Inbred Strains'] | 21,046,015 | [['E02.319.267.100'], ['B01.050'], ['D09.947.875.359.448.500'], ['C18.452.394.750.149', 'C19.246.300'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.650.940.800.575.912.250.462.500'], ['D27.505.696.422'], ['A11.284.430.214.190.875.564.461', 'A11.284.835.626.461'], ['G02.111.665.550', 'G03.295.631', 'G03.796.550... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Technology assessment of liver transplantation; a study of the liver transplantation program in Groningen 1977-1987]. | The liver transplantation programme of the University Hospital of Groningen, the Netherlands, was evaluated on behalf of the Dutch Sick Fund Council. From 1978 to 1987 561 patients were put forward for liver transplantation (LTX). During this period, 76 orthotopic liver transplants were carried out, 8 of which were ret... | ['Adolescent', 'Adult', 'Biliary Atresia', 'Child', 'Female', 'Humans', 'Liver Cirrhosis, Biliary', 'Liver Transplantation', 'Male', 'Netherlands', 'Prognosis', 'Program Evaluation', 'Quality of Life', 'Reoperation', 'Tissue and Organ Procurement'] | 2,797,232 | [['M01.060.057'], ['M01.060.116'], ['C06.130.120.123', 'C06.198.125', 'C16.131.314.125'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.130.120.135.250.250', 'C06.552.150.250', 'C06.552.630.400', 'C23.550.355.412.400'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Expression of leukocytic adhesion molecules in a patient with common variable immunodeficiency]. | BACKGROUND: Common variable immunodeficiency is one of the main antibodies' deficiency syndromes.OBJECTIVE: To present the immunological study of a 29-year-old patient with common variable immunodeficiency who assisted to a check-up after being four years without treatment with gammaglobuline.MATERIAL AND METHODS: We s... | ['Adult', 'Antigens, CD', 'Blood', 'Cell Adhesion Molecules', 'Common Variable Immunodeficiency', 'Flow Cytometry', 'Humans', 'Immunoglobulins', 'Immunophenotyping', 'Leukocyte Count', 'Lymphocyte Activation', 'Lymphocyte Subsets', 'Male', 'Saliva'] | 15,119,751 | [['M01.060.116'], ['D23.050.301.264.035', 'D23.101.100.110'], ['A12.207.152', 'A15.145'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['C20.673.330'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans. | BACKGROUND: Triosephosphate isomerase (TPI) is a central and conserved glycolytic enzyme. In humans, TPI is encoded by a single gene on 12p13, and associated with a rare genetic disorder, TPI deficiency. Reduced TPI activity can increase specific oxidant resistances of model organisms and TPI null-alleles have been hyp... | ['Aged, 80 and over', 'Female', 'Gene Frequency', 'Genetic Variation', 'Genotype', 'Germany', 'Humans', 'Isoenzymes', 'Male', 'Mutation', 'Polymorphism, Single Nucleotide', 'Sequence Analysis, DNA', 'Triose-Phosphate Isomerase'] | 18,510,744 | [['M01.060.116.100.080'], ['G05.330'], ['G05.365'], ['G05.380'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['G05.365.590'], ['G05.365.795.598'], ['E05.393.760.700'], ['D08.811.399.475.200.775']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Mutations in sdh (succinate dehydrogenase genes) alter the thiamine requirement of Salmonella typhimurium. | Mutants lacking the first enzyme in de novo purine synthesis (PurF) can synthesize thiamine if increased levels of pantothenate are present in the culture medium (J. L. Enos-Berlage and D. M. Downs, J. Bacteriol. 178:1476-1479, 1996). Derivatives of purF mutants that no longer required pantothenate for thiamine-indepen... | ['Acyl Coenzyme A', 'Mutation', 'Pantothenic Acid', 'Salmonella typhimurium', 'Succinate Dehydrogenase', 'Succinates', 'Succinic Acid', 'Thiamine'] | 9,190,816 | [['D03.633.100.759.646.138.382.300', 'D08.211.211.300', 'D13.695.667.138.382.300', 'D13.695.827.068.382.300'], ['G05.365.590'], ['D02.478.520', 'D12.125.042.070.500'], ['B03.440.450.425.800.200.825', 'B03.660.250.150.710.160.760'], ['D05.500.562.750.249.500', 'D08.811.600.250.500.750.500', 'D08.811.600.250.875.249.500'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Left ventricular aneurysm repair: a comparison of linear versus patch remodeling. | BACKGROUND: Surgical repair of left ventricular (LV) aneurysm has been performed for around 50 years. However, the most appropriate surgical approach remains undetermined. This study was undertaken to compare the efficacy of 2 established techniques, linear versus patch remodeling, for repair of dyskinetic LV aneurysms... | ['Aged', 'Aged, 80 and over', 'Cardiac Surgical Procedures', 'Female', 'Follow-Up Studies', 'Heart Aneurysm', 'Heart Ventricles', 'Humans', 'Male', 'Middle Aged', 'Survival Rate', 'Ventricular Function, Left', 'Ventricular Function, Right'] | 19,686,997 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.100.376', 'E04.928.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C14.280.358', 'C14.907.055.608'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.985.550.900',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Acute and long-term results of slow pathway ablation in patients with atrioventricular nodal reentrant tachycardia--an analysis of the predictive factors for arrhythmia recurrence. | BACKGROUND: Predictors of atrioventricular nodal reentrant tachycardia (AVNRT) recurrence after radiofrequency ablation including the importance of residual slow pathway conduction are not known. The aim of this study was to report the acute and long-term results of slow pathway ablation in a large series of consecutiv... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Catheter Ablation', 'Child', 'Electrophysiologic Techniques, Cardiac', 'Female', 'Humans', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Proportional Hazards Models', 'Recurrence', 'Statistics, Nonparametric', 'Tachycardia, Atrioventricular Nodal Reentry', 'T... | 15,679,639 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.808.750.500', 'E04.014.760.500'], ['M01.060.406'], ['E01.370.370.380.245', 'E01.370.405.267'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Usefulness of targeting lymphocyte Kv1.3-channels in the treatment of respiratory diseases. | T lymphocytes predominantly express delayed rectifier K(+)-channels (Kv1.3) in their plasma membranes. Patch-clamp studies revealed that the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental ani... | ['Animals', 'Drug Delivery Systems', 'Humans', 'Kv1.3 Potassium Channel', 'Lymphocytes', 'Macrolides', 'Potassium Channel Blockers', 'Respiratory Tract Diseases'] | 26,206,235 | [['B01.050'], ['E02.319.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.400.600.900.500.217', 'D12.776.543.550.450.750.900.124.358', 'D12.776.543.585.400.750.900.624.217'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['D02.540.505', 'D02.540.576.500', 'D04.345.67... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Juvenile granulosa cell tumor of the testis. | Juvenile granulosa cell tumor occurred in a newborn. The tumor presented with testicular torsion, and no malformations were observed. The karyotype was normal. The occurrence of initial tumoral lesions in the seminiferous tubules located in the vicinity of the tumor suggests that the tumor originated from immature Sert... | ['Granulosa Cell Tumor', 'Humans', 'Infant, Newborn', 'Male', 'Testicular Neoplasms'] | 3,178,427 | [['C04.557.475.750.656', 'C04.588.322.455.398', 'C13.351.500.056.630.705.398', 'C13.351.937.418.685.398', 'C19.344.410.398', 'C19.391.630.705.398'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C04.588.322.762', 'C04.588.945.440.915', 'C12.294.260.937', 'C12.758.409.937', 'C19.344.762', 'C19.... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A male incumbent worker industrial database. Part III: Lumbar/cervical functional testing. | STUDY DESIGN: A group of 160 incumbent male railroad workers was administered a battery of isokinetic and isoinertial lumbar/cervical lifting tests that served as a paradigm for whole-person functional testing of manual handling tasks.RESULTS: Results demonstrated that the workers' performance was near normal or somewh... | ['Activities of Daily Living', 'Adult', 'Cervical Vertebrae', 'Databases, Factual', 'Humans', 'Industry', 'Lifting', 'Lumbar Vertebrae', 'Male', 'Muscles', 'Occupations', 'Physical Examination', 'Railroads', 'Range of Motion, Articular', 'Reference Values'] | 8,202,793 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116'], ['A02.835.232.834.151'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.576'], ['G01.374.669'], ['A02.835.232.834.519'], ['A02.633', 'A10.690'], ['N01.824.547'], ['E01.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Anatomy [A]', 'Information Science [L]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 |
Involvement of globus pallidus and midbrain nuclei in pantothenate kinase-associated neurodegeneration: measurement of T2 and T2* time. | PURPOSE: To quantify involvement of globus pallidus and two midbrain nuclei (substantia nigra and red nucleus) in Pantothenate Kinase-Associated Neurodegeneration (PKAN).MATERIAL AND METHODS: We performed T2 and T2* weighted imaging with calculation of the corresponding relaxation times on a subset of 5 patients from a... | ['Adolescent', 'Female', 'Globus Pallidus', 'Humans', 'Image Interpretation, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Mesencephalon', 'Pantothenate Kinase-Associated Neurodegeneration', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Young Adult'] | 22,258,188 | [['M01.060.057'], ['A08.186.211.200.885.287.249.487.397'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E01.370.350.825.500'], ['A08.186.211.132.659'], ['C10.228.140.079.800', 'C10.228.140.744.320', 'C10.228.662.575', 'C10.574.500.700', 'C16.320.4... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Vaccination of children in 1999]. | Childhood immunization programs are regularly reevaluated to take into account epidemiologic changes in the diseases covered by the vaccines as well as the development of new vaccines. Among the significant additions brought in Belgium to the childhood immunization program in recent years are immunization against hepat... | ['Belgium', 'Child', 'Hepatitis B', 'Hepatitis B Vaccines', 'Humans', 'Immunization Programs', 'Immunization, Secondary', 'Infant', 'Measles Vaccine', 'Measles-Mumps-Rubella Vaccine', 'Mumps Vaccine', 'Pertussis Vaccine', 'Poliovirus Vaccine, Inactivated', 'Rubella Vaccine', 'Vaccination', 'Vaccines, Combined'] | 10,523,915 | [['Z01.542.115'], ['M01.060.406'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D20.215.894.899.955.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.726.608'], ['E02.095.465.425.400.485', 'E05.478.550.550'], ['M01.060.703'], ['D20.215.894.899.404'], ['D20.215.... | ['Geographicals [Z]', 'Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Chaetocin reactivates the lytic replication of Epstein-Barr virus from latency via reactive oxygen species. | Oxidative stress, regarded as a negative effect of free radicals in vivo, takes place when organisms suffer from harmful stimuli. Some viruses can induce the release of reactive oxygen species (ROS) in infected cells, which may be closely related with their pathogenicity. In this report, chaetocin, a fungal metabolite ... | ['Acetylcysteine', 'Animals', 'Antigens, Viral', 'B-Lymphocytes', 'Blotting, Western', 'Callithrix', 'Cell Line, Transformed', 'Dose-Response Relationship, Drug', 'Free Radical Scavengers', 'Gene Expression Regulation', 'Glutathione Peroxidase', 'Herpesvirus 4, Human', 'Histones', 'Host-Pathogen Interactions', 'Humans'... | 28,063,010 | [['D02.886.030.230.259', 'D12.125.166.230.259'], ['B01.050'], ['D23.050.327'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The trichrome-stained smear as a screening method for intestinal parasites: evaluation in a San Francisco Bay Area population. | The trichrome-stained smear and the formalin-ether concentrate were compared for detecting and identifying intestinal parasites. Using both methods, 15,414 outpatient and inpatient specimens were examined. Of 2,773 intestinal parasites recovered, 2,633 (94.9%) were protozoa. The trichrome-stained smear detected 97.0% o... | ['Azo Compounds', 'Coloring Agents', 'Eosine Yellowish-(YS)', 'Ethers', 'Feces', 'Formaldehyde', 'Helminthiasis', 'Humans', 'Intestinal Diseases, Parasitic', 'Methyl Green', 'Protozoan Infections', 'Staining and Labeling'] | 6,180,639 | [['D02.172'], ['D27.720.233'], ['D02.455.426.779.347.325', 'D03.633.300.953.275.325', 'D04.711.347.325'], ['D02.355'], ['A12.459'], ['D02.047.407'], ['C01.610.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.432', 'C06.405.469.452'], ['D02.092.146.475'], ['C01.610.752'], ['E01.370.225.500.620.670', 'E0... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long-term succinylcholine infusion during isoflurane anesthesia. | The characteristics of the neuromuscular blockade produced by prolonged succinylcholine infusion were compared in 40 patients anesthetized with either nitrous-oxide-isoflurane (0.75-1.50% inspired) or nitrous-oxide-fentanyl. Neuromuscular transmission was monitored using train-of-four stimulation and the infusion rate ... | ['Adult', 'Aged', 'Anesthesia, Inhalation', 'Drug Interactions', 'Electric Stimulation', 'Female', 'Fentanyl', 'Humans', 'Isoflurane', 'Male', 'Methyl Ethers', 'Middle Aged', 'Neuromuscular Junction', 'Nitrous Oxide', 'Succinylcholine', 'Synaptic Transmission', 'Tachyphylaxis'] | 6,293,347 | [['M01.060.116'], ['M01.060.116.100'], ['E03.155.197.197'], ['G07.690.773.968'], ['E05.723.402'], ['D03.383.621.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.355.601.570'], ['D02.355.601'], ['M01.060.116.630'], ['A08.800.550.550.550', 'A08.850.550.550', 'A11.284.149.165.420.780.550.550'], ['D01.362.635.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Control and estimation of anaerobic digestion processes using hydrogen and volatile fatty acids measurements. | The anaerobic digestion (AD) technology is widely used in the treatment of waste and wastewater. To ensure the treatment efficiency and to increase the production of biogas, which can be reused as a renewable energy source, a good understanding of the process and tight control are needed. This paper presents an estimat... | ['Anaerobiosis', 'Biofuels', 'Bioreactors', 'Fatty Acids, Volatile', 'Hydrogen', 'Waste Disposal, Fluid'] | 30,629,530 | [['G02.111.062', 'G03.078'], ['D20.147', 'N06.230.132.644.124'], ['E07.115', 'J01.897.120.115'], ['D10.251.400'], ['D01.268.406', 'D01.362.340'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Characterization of murine cytomegalovirus m157 from infected cells and identification of critical residues mediating recognition by the NK cell receptor Ly49H. | Activated NK cells mediate potent cytolytic and secretory effector functions and are vital components of the early antiviral immune response. NK cell activities are regulated by the assortment of inhibitory receptors that recognize MHC class I ligands expressed on healthy cells and activating receptors that recognize i... | ['Animals', 'Antibodies, Monoclonal', 'Antigens, Ly', 'Cell Line', 'Cell Membrane', 'Gene Expression Regulation, Viral', 'Glycoproteins', 'Glycosylphosphatidylinositols', 'Lectins, C-Type', 'Mice', 'Models, Molecular', 'Muromegalovirus', 'Mutation', 'NK Cell Lectin-Like Receptor Subfamily A', 'Protein Binding', 'Protei... | 18,566,392 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301.264.920', 'D23.101.100.920'], ['A11.251.210'], ['A11.284.149'], ['G05.308.385'], ['D09.400.430', 'D12.776.395'], ['D09.400.410.475', 'D10.390.475', 'D10.570.755.375.760.400.942.250'], ['D12.776.503... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multiple sensitive periods in the development of the primate visual system. | Early in life, abnormal visual experience may disrupt the developmental processes required for the maturation and maintenance of normal visual function. The effects of retinal image deprivation (monocular form deprivation) on four psychophysical functions were investigated in rhesus monkeys to determine if the sensitiv... | ['Age Factors', 'Animals', 'Humans', 'Macaca mulatta', 'Photoreceptor Cells', 'Sensory Deprivation', 'Space Perception', 'Vision, Ocular', 'Visual Perception'] | 3,952,507 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['A08.675.650.850.625', 'A08.675.650.915.937', 'A08.800.950.937', 'A09.371.729.831.625', 'A11.671.650.850.625', 'A11.671.650.915.937'], ['F02.463.593.696'], ['F... | ['Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
In vitro evaluation of sustained ciprofloxacin release from ê-carrageenan-crosslinked chitosan/hydroxyapatite hydrogel nanocomposites. | Although the traditional hydrogels have shown great potential applications in designing drug delivery systems, the burst release of drugs remains an issue. In this work, we develop and evaluate a sustained release of ciprofloxacin using chitosan/hydroxyapatite/ê-carrageenan complexes. The size and structure of HA nanop... | ['Anti-Bacterial Agents', 'Carrageenan', 'Chitosan', 'Ciprofloxacin', 'Cross-Linking Reagents', 'Drug Liberation', 'Durapatite', 'Escherichia coli', 'Hydrogels', 'Kinetics', 'Microbial Sensitivity Tests', 'Nanocomposites', 'Spectrometry, X-Ray Emission', 'Spectroscopy, Fourier Transform Infrared', 'Staphylococcus aureu... | 30,594,616 | [['D27.505.954.122.085'], ['D09.698.152'], ['D05.750.078.139.500', 'D09.698.211.500'], ['D03.633.100.810.835.322.186'], ['D27.720.470.410.210'], ['G02.211', 'G03.787.321', 'G07.690.725.321'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Extensive lesions of cholinergic basal forebrain neurons do not impair spatial working memory. | A recent study suggests that lesions to all major areas of the cholinergic basal forebrain in the rat (medial septum, horizontal limb of the diagonal band of Broca, and nucleus basalis magnocellularis) impair a spatial working memory task. However, this experiment used a surgical technique that may have damaged cerebel... | ['Acetylcholine', 'Animals', 'Cholinergic Fibers', 'Male', 'Memory, Short-Term', 'Neurons', 'Prosencephalon', 'Rats', 'Rats, Long-Evans', 'Space Perception'] | 14,747,521 | [['D02.092.211.111'], ['B01.050'], ['A08.675.127.500', 'A08.675.542.234', 'A11.671.188.500', 'A11.671.501.234'], ['F02.463.425.540.407'], ['A08.675', 'A11.671'], ['A08.186.211.200'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.500'], ['F02.463.593.778']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A critical coiled coil motif in the small terminase, gp16, from bacteriophage T4: insights into DNA packaging initiation and assembly of packaging motor. | Double-stranded DNA packaging in bacteriophages is driven by one of the most powerful force-generating molecular motors reported to date. The phage T4 motor is composed of the small terminase protein, gpl6 (18kDa), the large terminase protein, gp17 (70kDa), and the dodecameric portal protein gp20 (61kDa). gp16, which e... | ['Adenosine Triphosphatases', 'Amino Acid Motifs', 'Amino Acid Sequence', 'Bacteriophage T4', 'DNA Packaging', 'DNA-Binding Proteins', 'Endodeoxyribonucleases', 'Gene Expression', 'Hydrogen-Ion Concentration', 'Models, Molecular', 'Molecular Motor Proteins', 'Molecular Sequence Data', 'Mutation', 'Protein Structure, Se... | 16,513,134 | [['D08.811.277.040.025'], ['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B04.123.150.500.350', 'B04.123.205.891.200', 'B04.280.090.500.350'], ['G04.400', 'G05.213'], ['D12.776.260'], ['D08.811.277.352.335.350', 'D08.811.277.352.355.325'], ['G05.297'], ['G02... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Stratified cylindrical epithelium of the human urethra. Apropos of various cytological observations on urocytograms]. | The stratified columnar cells of the human urethra were studied by the filtering membrane technique in urocytograms usually effected, or in smears made after a cytoscopy or after an ejaculation. The cells were present in 61% of systematic filters without inflammation, in 82% of inflammatory filters, and in the urine of... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Ejaculation', 'Epithelial Cells', 'Epithelium', 'Female', 'Humans', 'Male', 'Middle Aged', 'Therapeutic Irrigation', 'Urethra', 'Urethritis'] | 1,790,351 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['G08.686.784.084'], ['A11.436'], ['A10.272'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.779.492.500', 'E02.831.535.492.500', 'E05.927'], ['A05.360.444.492.726', 'A05.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers. | p53 Mutations are found in up to 30% of breast cancers and peptides derived from over-expressed p53 protein are presented by class I HLA molecules and may act as tumor-associated epitopes in cancer vaccines. A dendritic cell (DC) based p53 targeting vaccine was analyzed in HLA-A2+ patients with progressive advanced bre... | ['Adipokines', 'Adult', 'Aged', 'Biomarkers, Tumor', 'Breast Neoplasms', 'Cancer Vaccines', 'Chitinase-3-Like Protein 1', 'Dendritic Cells', 'Female', 'Glycoproteins', 'Humans', 'Interleukin-6', 'Lectins', 'Middle Aged', 'Peptide Fragments', 'Tumor Suppressor Protein p53', 'Vaccination'] | 17,285,289 | [['D06.472.699.042', 'D12.644.276.024', 'D12.644.548.011', 'D12.776.467.024', 'D23.529.024'], ['M01.060.116'], ['M01.060.116.100'], ['D23.101.140'], ['C04.588.180', 'C17.800.090.500'], ['D20.215.894.200'], ['D08.811.277.450.207.500', 'D12.776.503.070'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[The problem with endoleakage in endoluminal therapy]. | Endovascular treatment of aortic aneurysms with stent grafts was performed increasingly in recent years. The most frequent complication after endovascular therapy of aortic aneurysms is an endoleak. In case of a persistent endoleak, diameter of the aneurysm is increasing with a high risk of aneurysm rupture. Diagnostic... | ['Aneurysm, Dissecting', 'Aortic Aneurysm, Abdominal', 'Aortography', 'Blood Vessel Prosthesis Implantation', 'Humans', 'Postoperative Complications', 'Prosthesis Failure', 'Reoperation', 'Stents', 'Tomography, X-Ray Computed', 'Treatment Failure'] | 11,552,381 | [['C14.907.055.050'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['E01.370.350.700.060.070', 'E01.370.370.050.070'], ['E04.100.814.868.500', 'E04.650.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.767'], ['C23.550.767.865', 'E05.325.771'], ['E04.690'], ['E07.695.750'], ['E01.370.350.350.810', 'E... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Negative regulation of bovine growth hormone gene by YY1 binding to NRE's. | We have previously demonstrated the presence of three negative regulatory elements (NRE1, 2, and 3) in the upstream region of the bovine growth hormone (bGH) gene, whose sequences are similar to the binding elements of transcription factor YY1. The recombinant human YY1 protein indeed bound to these three NRE's in vitr... | ['Animals', 'Binding, Competitive', 'Cattle', 'DNA-Binding Proteins', 'Erythroid-Specific DNA-Binding Factors', 'Gene Expression Regulation', 'Growth Hormone', 'HeLa Cells', 'Humans', 'Nuclear Proteins', 'Promoter Regions, Genetic', 'Protein Binding', 'Rats', 'Recombinant Proteins', 'Transcription Factors', 'YY1 Transc... | 8,941,348 | [['B01.050'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['B01.050.150.900.649.313.500.380.271'], ['D12.776.260'], ['D12.776.260.235', 'D12.776.930.216'], ['G05.308'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Could clinical decision rules relying on cardiovascular risk models increase psychosocial inequalities in health? Results from the PRIME cohort study. | OBJECTIVE: Guidelines on cardiovascular prevention relying on common cardiovascular risk scoring could result in delayed drug therapy for patients with low psychosocial status because of underestimation of true cardiovascular risk. We aimed to assess the potential delay in drug therapy for subjects with adverse psychos... | ['Age Factors', 'Cardiovascular Diseases', 'Cohort Studies', 'Comorbidity', 'Decision Making', 'Depression', 'France', 'Health Status Disparities', 'Humans', 'Male', 'Middle Aged', 'Models, Cardiovascular', 'Risk Assessment', 'Social Class', 'Time Factors'] | 21,540,049 | [['N05.715.350.075', 'N06.850.490.250'], ['C14'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N05.715.350.225', 'N06.850.490.687'], ['F02.463.785.373'], ['F01.145.126.350'], ['Z01.542.286'], ['I01.240.425.675', 'N01.224.425.437', 'N06.850.505.400.425.675'], ['B01.050.150.900.649.313... | ['Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Application of SAS macro to evaluated multiplicative and additive interaction in logistic and Cox regression in clinical practices]. | Conditional logistic regression analysis and unconditional logistic regression analysis are commonly used in case control study, but Cox proportional hazard model is often used in survival data analysis. Most literature only refer to main effect model, however, generalized linear model differs from general linear model... | ['Case-Control Studies', 'Humans', 'Logistic Models', 'Proportional Hazards Models', 'Survival Analysis'] | 27,188,374 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695.470', 'N06.850.520.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Socioeconomic differences in the burden of disease in Sweden. | OBJECTIVE: We sought to analyse how much of the total burden of disease in Sweden, measured in disability-adjusted life years (DALYs), is a result of inequalities in health between socioeconomic groups. We also sought to determine how this unequal burden is distributed across different disease groups and socioeconomic ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Cardiovascular Diseases', 'Cost of Illness', 'Depression', 'Disabled Persons', 'Disease', 'Female', 'Health Status Disparities', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Quality-Adjusted Life Years', 'Social Class', 'Sweden'] | 15,744,401 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['F01.145.126.350'], ['M01.150'], ['C23.550.288'], ['I01.240.425.675', 'N01.224.425.437', 'N06.850.505.400.425.675'], ['B01.050.150.900.649... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Multisite effectiveness trials of treatments for substance abuse and co-occurring problems: have we chosen the best designs? | Multisite effectiveness trials such as those carried out in the National Drug Abuse Treatment Clinical Trials Network (CTN) are a critical step in the development and dissemination of evidence-based treatments because they address how such treatments perform in real-world clinical settings. As Brigham et al. summarized... | ['Community Health Services', 'Comparative Effectiveness Research', 'Evidence-Based Medicine', 'Humans', 'Information Dissemination', 'National Institute on Drug Abuse (U.S.)', 'Randomized Controlled Trials as Topic', 'Research Design', 'Substance Abuse Treatment Centers', 'Substance-Related Disorders', 'Treatment Outc... | 20,307,801 | [['N02.421.143'], ['H01.770.644.145.360.500', 'N05.425.157'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.143.443'], ['I01.409.418.750.600.650.496.485', 'N03.540.052.750.485', 'N03.540.348.500.500.600.650.496.485'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.... | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Expression of platelet-bound stromal cell-derived factor-1 in patients with non-valvular atrial fibrillation and ischemic heart disease. | AIMS: Blood cell infiltration and inflammation are involved in atrial remodelling during atrial fibrillation (AF) although the exact mechanisms of inflammatory cell recruitment remain poorly understood. Platelet-bound stromal cell-derived factor-1 (SDF-1) is increased in cases of ischemic myocardium and regulates recru... | ['Angina, Stable', 'Atrial Fibrillation', 'Blood Platelets', 'Cell Movement', 'Chemokine CXCL12', 'Gene Expression Regulation', 'Humans', 'Myocardial Ischemia', 'Stem Cells'] | 22,044,645 | [['C14.280.647.187.362', 'C14.907.585.187.362', 'C23.888.592.612.233.500.575'], ['C14.280.067.198', 'C23.550.073.198'], ['A11.118.188', 'A15.145.229.188'], ['G04.198', 'G07.568.500.180'], ['D12.644.276.374.200.120.600', 'D12.776.467.374.200.120.600', 'D23.125.300.120.600', 'D23.469.200.120.600', 'D23.529.374.200.120.60... | ['Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ultrasonographic assessment of colonic wall in moderate-severe ulcerative colitis: comparison with endoscopic findings. | BACKGROUND: Bowel ultrasound has been shown to be a useful tool to evaluate patients with inflammatory bowel disease, especially Crohn's disease. However, such data are still scarce in ulcerative colitis patients.AIMS: To establish the value of bowel ultrasound in moderate to severe ulcerative colitis patients, and com... | ['Adolescent', 'Adult', 'Aged', 'C-Reactive Protein', 'Colitis, Ulcerative', 'Colon', 'Colonoscopy', 'Female', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Severity of Illness Index', 'Ultrasonography', 'Young Adult'] | 21,482,208 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['E01.370.372.250.250.200', 'E01.370.388.250.250.25... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Acid-Labile Amphiphilic PEO-b-PPO-b-PEO Copolymers: Degradable Poloxamer Analogs. | Poly ((ethylene oxide)-b-(propylene oxide)-b-(ethylene oxide)) triblock copolymers commonly known as poloxamers or Pluronics constitute an important class of nonionic, biocompatible surfactants. Here, a method is reported to incorporate two acid-labile acetal moieties in the backbone of poloxamers to generate acid-clea... | ['Biodegradable Plastics', 'Hydrolysis', 'Polyethylene Glycols', 'Surface Tension'] | 27,000,789 | [['D05.750.716.195', 'D25.720.716.195', 'J01.637.051.720.716.195'], ['G02.380'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], ['G02.860.816']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Mechanical versus drug prevention of thrombosis after total hip endoprosthesis implantation. A randomized, controlled clinical study]. | Pharmacological prophylaxis is routinely applied after total hip replacement. Although it effectively reduces deep-vein thrombosis, side effects (bleeding, haematoma, swelling, thrombocytopenia) are not infrequent. Since in Germany use of foot pumps as only means of prophylaxis is unpopular, we investigated their effic... | ['Adult', 'Aged', 'Anticoagulants', 'Arthroplasty, Replacement, Hip', 'Bandages', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nadroparin', 'Outcome and Process Assessment, Health Care', 'Physical Therapy Modalities', 'Postoperative Complications', 'Pulmonary Embolism', 'Thrombocytopenia', 'Treatment Outcome', 'Ultrason... | 12,910,861 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.502.119'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['E07.101'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D09.698.373.400.300.600'], ['N04.761.559', 'N05.715.360.575'], ['E02.779', 'E02.831.535'], ['C23.550.767... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Healthcare-associated infections are associated with insufficient dietary intake: an observational cross-sectional study. | BACKGROUND: Indicators to predict healthcare-associated infections (HCAI) are scarce. Malnutrition is known to be associated with adverse outcomes in healthcare but its identification is time-consuming and rarely done in daily practice. This cross-sectional study assessed the association between dietary intake, nutriti... | ['Aged', 'Aged, 80 and over', 'Cross Infection', 'Cross-Sectional Studies', 'Energy Intake', 'Female', 'Hospitalization', 'Hospitals, General', 'Humans', 'Logistic Models', 'Male', 'Malnutrition', 'Middle Aged', 'Multivariate Analysis', 'Nutrition Assessment', 'Odds Ratio', 'Risk Factors', 'Severity of Illness Index'] | 25,923,783 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C01.248', 'C23.550.291.875.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.203.650.240.340'], ['E02.760.400', 'N02.421.585.400'], ['N02.278.421.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prevalence and impact of urinary incontinence in men with cystic fibrosis. | OBJECTIVES: To determine the prevalence and impact of urinary incontinence (UI) in men with cystic fibrosis (CF).DESIGN: Prospective observational study.SETTING: Adult CF clinics at tertiary referral centres.PARTICIPANTS: Men with CF (n=80) and age-matched men without lung disease (n=80).INTERVENTIONS: Validated questi... | ['Adult', 'Anxiety', 'Cystic Fibrosis', 'Depression', 'Humans', 'Male', 'Mental Health', 'Prevalence', 'Prospective Studies', 'Quality of Life', 'Urinary Incontinence'] | 25,700,635 | [['M01.060.116'], ['F01.470.132'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.418', 'N01.400.500'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['E05.318.3... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Sleepsex: a variant of sleepwalking. | Sexual acts performed by a sleeping subject have been rarely reported. Two cases are now presented involving sexual behavior performed while asleep. The first case involves the hitherto unreported association of sleepsex with sleepeating. The second case concerns a rarely reported act of sexual battery by a known sleep... | ['Adult', 'Feeding and Eating Disorders', 'Humans', 'Male', 'Sex Offenses', 'Sexual Behavior', 'Sexual Dysfunctions, Psychological', 'Somnambulism'] | 9,604,116 | [['M01.060.116'], ['F03.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.198.240.748'], ['F01.145.802'], ['F03.835'], ['C10.886.659.635.700', 'F03.870.664.635.700']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives. | 4,4″-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against T rypanosoma brucei rhodesiense , Trypanosoma cruzi , Plasmodium falciparum , and Leishmania amazonensis . Twenty-three compounds were highly active against T. b. rhodesiense or P. falciparum. Most noteworthy were amidines 1, 10,... | ['Animals', 'Antiprotozoal Agents', 'Benzene', 'Chagas Disease', 'Female', 'Leishmania donovani', 'Mice', 'Mice, Inbred Strains', 'Models, Chemical', 'Molecular Structure', 'Parasitic Sensitivity Tests', 'Plasmodium falciparum', 'Pyridines', 'Structure-Activity Relationship', 'Terphenyl Compounds', 'Trypanosoma cruzi'] | 23,795,673 | [['B01.050'], ['D27.505.954.122.250.100'], ['D02.455.426.559.389.023'], ['C01.610.752.300.900.200', 'C01.920.625'], ['B01.268.475.868.488.230'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['E05.599.495'], ['G02.111.570', 'G02.466'], ['E01.370... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transluminal repair of an infrarenal aortoiliac aneurysm by a combination of bifurcated and branched stent grafts. | Transfemoral endovascular repair with a combination of bifurcated and branched stent grafts enables aortoiliac reconstruction with internal iliac perfusion preserved. We report a case of successful endovascular repair of aortoiliac aneurysm with use of a bifurcated and branched stent-graft. | ['Aged', 'Aged, 80 and over', 'Aortic Aneurysm, Abdominal', 'Blood Vessel Prosthesis Implantation', 'Humans', 'Iliac Aneurysm', 'Male', 'Stents', 'Tomography, X-Ray Computed'] | 10,470,482 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['E04.100.814.868.500', 'E04.650.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.055.625'], ['E07.695.750'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. | Many observations suggest the presence of transmembrane linkages between the cytoskeleton and the extracellular matrix. In fibroblasts both light and electron microscopic observations reveal a co-alignment between actin filaments at the cell surface and extracellular fibronectin. These associations are seen at sites of... | ['Animals', 'Cell Membrane', 'Chickens', 'Chromatography, Gel', 'Molecular Weight', 'Muscle Proteins', 'Receptors, Fibronectin', 'Receptors, Immunologic', 'Talin', 'Vinculin'] | 2,938,015 | [['B01.050'], ['A11.284.149'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E05.196.181.400.250'], ['G02.494'], ['D12.776.210.500'], ['D12.776.543.750.705.408.530'], ['D12.776.543.750.705'], ['D12.776.220.985'], ['D12.776.220.990']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Presenile dementia with motor neuron disease in Japan. A new entity? | A 61-year-old woman suffered the gradual onset of difficulty with memory, concentration, and cognition at age 58. Progressively more severe dementia was accompanied by muscle wasting and fasciculation prominent in hand and bulbar muscles. An electromyogram and a muscle biopsy specimen demonstrated denervation patterns,... | ['Dementia', 'Female', 'Humans', 'Middle Aged', 'Motor Neurons', 'Neuromuscular Diseases'] | 475,629 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A three-dimensional and volume determination of tumors of the cerebellopontine angle. | We propose a new technique to accurately determine the volume of cerebellopontine angle (CPA) tumors. It has been determined that the measurement of the long axis in a slice plane of the CPA tumor does not adequately measure the total growth of the tumor. Volume measurements are more accurate indicators of the mass of ... | ['Aged', 'Cerebellar Neoplasms', 'Cerebellopontine Angle', 'Female', 'Humans', 'Male', 'Meningeal Neoplasms', 'Meningioma', 'Middle Aged', 'Neuroma, Acoustic', 'Stereotaxic Techniques', 'Tomography, X-Ray Computed'] | 6,753,201 | [['M01.060.116.100'], ['C04.588.614.250.195.411.211', 'C10.228.140.211.500.200', 'C10.228.140.252.200', 'C10.551.240.250.400.300'], ['A08.186.211.132.810.428.200.462'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.614.250.580', 'C10.551.240.500'], ['C04.557.580.520', 'C04.557.645.520', 'C04.588.614.250.58... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Structure of the bovine VASAP-60/PRKCSH gene, functional analysis of the promoter, and gene expression analysis. | Vacuolar system-associated protein-60 (VASAP-60) constitutes the bovine ortholog of the human "protein kinase C substrate 80K-H" (PRKCSH or 80K-H). We characterized the bovine VASAP-60/PRKCSH gene structure and promoter, identified cis-acting elements controlling VASAP-60 expression, searched for mRNA splice variants, ... | ['Alternative Splicing', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cattle', 'Cell Line', 'Electrophoretic Mobility Shift Assay', 'Exons', 'Female', 'Gene Expression Profiling', 'Granulosa Cells', 'Introns', 'Luciferases', 'Male', 'Membrane Proteins', 'Molecular Sequence Data', 'Ovarian Follicle', 'Promoter Re... | 17,250,974 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251.210'], ['E05.196.401.500'], ['G05.360.340.024.340.137.232'], ['E05.393.332'], ['A05.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
In silico prediction and in vivo analysis of antiestrogenic potential of 2-isopropylthioxanthone (2-ITX) in juvenile goldfish (Carassius auratus). | Previous studies have shown both anti-estrogenic and anti-androgenic activities of 2-isopropylthioxanthone (2-ITX), a well known food contaminant, in in vitro assays. However, no data are available on the anti-estrogenic potentials and risks of 2-ITX in aquatic organisms. This work evaluated the potential endocrine dis... | ['Adolescent', 'Animals', 'Computer Simulation', 'Endocrine Disruptors', 'Estrogen Antagonists', 'Estrogen Receptor alpha', 'Gene Expression', 'Goldfish', 'Humans', 'Liver', 'Molecular Docking Simulation', 'Receptors, Aryl Hydrocarbon', 'Thioxanthenes', 'Vitellogenins'] | 27,454,205 | [['M01.060.057'], ['B01.050'], ['L01.224.160'], ['D27.505.696.353', 'D27.888.141'], ['D06.347.295', 'D27.505.696.399.450.327'], ['D12.776.826.750.350.174'], ['G05.297'], ['B01.050.150.900.493.200.244.248.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['E05.599.595.249', 'L01.224.160.249'], ['D12.7... | ['Named Groups [M]', 'Organisms [B]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
GSTM1, GSTT1, GSTP1, CYP1A1, and NAT1 polymorphisms, tobacco use, and the risk of head and neck cancer. | Squamous cell carcinoma of the head and neck (SCCHN), including the oral cavity, pharynx, and larynx, provides an ideal tumor model to investigate gene-environment interaction. We conducted a hospital-based case-control study including 182 cases with newly diagnosed SCCHN and 202 controls with nonneoplastic conditions ... | ['Acetyltransferases', 'Adult', 'Aged', 'Arylamine N-Acetyltransferase', 'Carcinoma, Squamous Cell', 'Case-Control Studies', 'Cytochrome P-450 CYP1A1', 'Female', 'Glutathione Transferase', 'Head and Neck Neoplasms', 'Humans', 'Isoenzymes', 'Male', 'Middle Aged', 'Polymorphism, Genetic', 'Risk Factors', 'Smoking'] | 10,698,480 | [['D08.811.913.050.134'], ['M01.060.116'], ['M01.060.116.100'], ['D08.811.913.050.134.138'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D08.244.453.005.332', 'D08.244.453.100.500', 'D08.811.682.690.708.170.010.277', 'D08.811.682.690.7... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Does seeing an Asian face make speech sound more accented? | Prior studies have reported that seeing an Asian face makes American English sound more accented. The current study investigates whether this effect is perceptual, or if it instead occurs at a later decision stage. We first replicated the finding that showing static Asian and Caucasian faces can shift people's reports ... | ['Acoustic Stimulation', 'Adaptation, Psychological', 'Adult', 'Asian Continental Ancestry Group', 'European Continental Ancestry Group', 'Face', 'Facial Recognition', 'Female', 'Humans', 'Language', 'Learning', 'Male', 'Phonetics', 'Photic Stimulation', 'Speech', 'Speech Perception', 'Young Adult'] | 28,516,294 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['F01.058'], ['M01.060.116'], ['M01.686.508.200'], ['M01.686.508.400'], ['A01.456.505'], ['F02.463.593.524.250.500', 'F02.463.593.524.500.500', 'F02.463.593.932.622.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['F02.463.425', 'F0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Comparison of some postanaesthetic effects of atropine and glycopyrrolate with particular emphasis on urinary problems. | Two hundred and two patients undergoing elective surgery were given either atropine (98 patients) or glycopyrrolate (104 patients) for intravenous premedication and as an adjunct to reversal of neuromuscular block by neostigmine in a double-blind study. The dose ratio of atropine and glycopyrrolate was 2.5:1. After rev... | ['Adult', 'Atropine', 'Double-Blind Method', 'Female', 'Glycopyrrolate', 'Heart Rate', 'Humans', 'Male', 'Middle Aged', 'Nausea', 'Preanesthetic Medication', 'Pyrrolidines', 'Urinary Catheterization', 'Urination Disorders', 'Vomiting'] | 6,711,256 | [['M01.060.116'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D02.092.877.425', 'D02.675.276.425', 'D03.383.773.342'], ['E01.370.600.875.50... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
In vitro studies of poison oak immunity. I. In vitro reaction of human lymphocytes to urushiol. | Poison oak, ivy, and sumac dermatitis is a T-cell-mediated reaction against urushiol, the oil found in the leaf of the plants. This hapten is extremely lipophilic and concentrates in cell membranes. A blastogenesis assay employing peripheral blood lymphocytes obtained from humans sensitized to urushiol is described. Th... | ['Adolescent', 'Adult', 'Alkenes', 'Binding Sites, Antibody', 'Catechols', 'Cells, Cultured', 'Chemical Phenomena', 'Chemistry', 'Dermatitis, Contact', 'Humans', 'Immunity, Cellular', 'In Vitro Techniques', 'Macrophages', 'Middle Aged', 'Oils', 'Plant Extracts', 'Plants, Toxic', 'T-Lymphocytes'] | 315,414 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ovulation induction with low-dose follicle-stimulating hormone in women with the polycystic ovary syndrome. | Fifty infertile women with the polycystic ovary syndrome (PCOS) were treated for 66 cycles with low-dose FSH stimulation starting with 75 IU FSH for two weeks before eventual stepwise increases in the gonadotropin dose occurred. An unifollicular response was observed in 35 (53%) cycles and in 20 (30%) cycles there were... | ['Adult', 'Female', 'Follicle Stimulating Hormone', 'Humans', 'Infertility, Female', 'Ovulation Induction', 'Polycystic Ovary Syndrome', 'Pregnancy', 'Treatment Outcome'] | 8,382,432 | [['M01.060.116'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.351.500.365.700'], ['E02.875.800.984', 'E05.820.800.984'], ['C04.182.612.765', 'C13.351.500.056.630.580.765', 'C19.391.630.580.765'], ['G08.686.784.769'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Origami microfluidic paper-analytical-devices (omPAD) for sensing and diagnostics. | Recent research activities in the area of low-cost sensing and diagnostics that are realized on cellulosic paper substrate are presented. First a three-dimensional origami paper-based analytical device (omPAD) with multiple electrochemical sensors, an integrated sample reservoir and tight integration with a custom CMOS... | ['Biosensing Techniques', 'Dopamine', 'Electrochemical Techniques', 'Electrodes', 'Imaging, Three-Dimensional', 'Metals', 'Microfluidic Analytical Techniques', 'Microtechnology', 'Optical Phenomena', 'Oxides', 'Paper', 'Point-of-Care Systems', 'Semiconductors'] | 28,268,338 | [['E05.601.043'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['E05.301'], ['E07.305.250'], ['E01.370.350.400', 'L01.224.308.410'], ['D01.552'], ['E05.588.465'], ['H01.570', 'J01.897.520.500'], ['G01.590'], ['D01.248.497.158.685', 'D01.650.550'], ['J01.637.650'], ['N04.452.442.452... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Organization of the sympathetic innervation in liver tissue from monkey and man. | The sympathetic innervation of the liver of monkey and man has been investigated in a combined fluorescence histochemical, chemical and electron microscopical study. By means of the Falck-Hillarp fluorescence method a dense network of monoamine-containing nerve fibers was visualized in liver tissue of monkey and man. T... | ['Animals', 'Chemical Phenomena', 'Chemistry', 'Haplorhini', 'Humans', 'Liver', 'Macaca mulatta', 'Microscopy, Fluorescence', 'Norepinephrine', 'Spectrometry, Fluorescence', 'Sympathetic Nervous System'] | 103,622 | [['B01.050'], ['G02'], ['H01.181'], ['B01.050.150.900.649.313.988.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['E01.370.350.515.458', 'E05.595.458'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', 'D02.092.311.830', 'D0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Co-administration of the low dose of orexin and nitrergic antagonists induces an antidepressant-like effect in mice. | It is now well-established that orexins (OXs) and their receptors are involved in the pathophysiology of depression. Considering the evidence indicating the importance of nitric oxide (NO) system in the mood modulation, this study investigated the effect of intraperitoneal (i.p.) administration of orexin 1 (OX1) recept... | ['Animals', 'Antidepressive Agents', 'Benzoxazoles', 'Depression', 'Dose-Response Relationship, Drug', 'Drug Therapy, Combination', 'Hindlimb Suspension', 'Locomotion', 'Male', 'Mice', 'NG-Nitroarginine Methyl Ester', 'Naphthyridines', 'Nitric Oxide', 'Orexins', 'Swimming', 'Treatment Outcome', 'Urea'] | 30,399,595 | [['B01.050'], ['D27.505.954.427.700.122'], ['D03.633.100.221'], ['F01.145.126.350'], ['G07.690.773.875', 'G07.690.936.500'], ['E02.319.310'], ['E05.472.760.370', 'E05.977.400', 'N06.230.150.440.950.400'], ['G07.568.500', 'G11.427.410.568'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.125.068.050.525', 'D12.125.0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
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