id stringlengths 24 24 | question stringlengths 21 168 | context stringlengths 79 19.2k | answer stringclasses 2
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587e440f2420191125000005 | Does CRISPR inversion of CTCF sites alter genome topology? | CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function To test the functional significance of this observation, we combined CRISPR/Cas9-based genomic-DNA-fragment editing with chromosome-conformation-capture experiments to show that the location and relative orientations of CBSs determine ... | yes |
58850ac7e56acf5176000012 | Is there a role of proton beam therapy in medulloblastoma treatment? | All papers directly compared outcomes from protons with photons, five papers included medulloblastoma, four papers each included craniopharyngioma and low grade gliomas and three papers included ependymoma. There are many indications of protontherapy for paediatric brain tumours in curative intent, either for localized... | yes |
588383172305cd7e21000004 | Are there canonical marks of active chromatin in developmentally regulated genes? | Absence of canonical marks of active chromatin in developmentally regulated genes. The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally regulated du... | no |
589206fc49702f2e01000003 | Are there methods for generating highly multiplexed ChIP-seq libraries? | A method for generating highly multiplexed ChIP-seq libraries. The barcoding of next generation sequencing libraries has become an essential part of the experimental design. Barcoding not only allows the sequencing of more than one sample per lane, but also reduces technical bias. However, current barcoding strategies ... | yes |
58cdb80302b8c60953000043 | Is Doxorubicin cardiotoxic? | Doxorubicin (DOXO) is widely used to treat solid tumors. However, its clinical use is limited by side effects including serious cardiotoxicity due to cardiomyocyte damage. The results provide direct evidence for the role of catalase in doxorubicin cardiotoxic responses. These results do not support the possibility tha... | yes |
58de34608acda3452900002b | Is the mouse Sry gene locus free of repetitive sequences? | We demonstrate that the presence of long inverted repeats (IR) flanking the mouse Sry gene leads to the formation of the Sry circular transcript in cultured cells Circularization requires the presence of both IR. As few as 400 complementary nt are necessary for this process The presence of the IR does not significantly... | no |
5892783d49702f2e01000004 | Is Meis1 implicated in microphthalmia? | Meis1 coordinates a network of genes implicated in eye development and microphthalmia. Here we show that haploinsufficiency of Meis1, which encodes a transcription factor with evolutionarily conserved expression in the embryonic trunk, brain and sensory organs, including the eye, causes microphthalmic traits and visual... | yes |
5890eb22621ea6ff7e000006 | Can Pentraxin 3 predict outcomes of sepsis? | As compared with low serum PTX3and sTWEAK cases, cirrhotic patients with high serum PTX3/sTWEAK levels a have higher probability of new severe infections, severe sepsis, septic shock, type 1 hepatorenal syndrome, in-hospital, and 3-month follow-up mortalities. Neonates with high nPTX3 concentrations also have lowered ... | yes |
58b5320e22d3005309000002 | Is ocular melanosis a risk factor for uveal melanoma? | Ocular/oculodermal (oculo[dermal]) melanocytosis is a congenital periocular pigmentary condition that can lead to the development of uveal melanoma, estimated at 1 in 400 affected patients. Melanosis oculi is often underestimated as a risk factor for uveal melanoma and glaucoma. Ophthalmic surveillance, every 6 or 12 m... | yes |
5896d3e278275d0c4a000012 | Is siltuximab effective for Castleman disease? | Siltuximab: a targeted therapy for idiopathic multicentric Castleman disease. The recent approvals in North America, Europe and Brazil of siltuximab, a monoclonal antibody against IL-6, for iMCD now provide a safe and effective therapy that targets a key aspect of pathogenesis. In the first ever randomized, placebo-con... | yes |
58cd522902b8c60953000038 | Is the enzyme EPRS phosphorylated? | Phosphorylation of glutamyl-prolyl tRNA synthetase (EPRS) has been investigated extensively in our laboratory for more than a decade, and has served as an archetype for studies of other AARSs. EPRS is dually phosphorylated by cyclin-dependent kinase 5 (Cdk5) at Ser(886) and then by a Cdk5-dependent-AGC kinase at Ser(99... | yes |
58c0836102b8c6095300001c | Is there a relationship between B cells and Multiple Sclerosis? | These results suggest that RRMS patients with radiological phenotypes showing high neurodegeneration have changes in B cells characterized by down-regulation of B-cell-specific genes and increased activation status Although the exact etiology is still obscure, the leading hypothesis behind MS relapses is acute inflamma... | yes |
58caf86f02b8c60953000030 | Does Yersinia pestis causes a respiratory infection? | Inhalation of Yersinia pestis results in primary pneumonic plague, a highly lethal and rapidly progressing necrotizing pneumonia Yersinia pestis causes the fatal respiratory disease pneumonic plague. Pulmonary infection by Yersinia pestis causes pneumonic plague, a rapidly progressing and often fatal disease. Pulmonary... | yes |
58eb7898eda5a57672000006 | Are the genes for marneral biosynthesis scattered in the genome of A. thaliana? | Here we characterize a second operon-like triterpene cluster (the marneral cluster) from A. thaliana, compare the features of these two clusters, and investigate the evolutionary events that have led to cluster formation Here we characterize a second operon-like triterpene cluster (the marneral cluster) from A. thalian... | no |
5883781b2305cd7e21000001 | Does Jarid2 play a role in early embryo development? | Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development Unlike other PRC2-deficient embryonic stem cells (ESCs), however, Jarid2-deficient ESCs show a severe differentiation block, altered colony morphology, and distinctive patterns of deregulate... | yes |
58bfe70e02b8c60953000019 | Is PUVA therapy indicated for eczema treatment? | With bath PUVA treatment, the best results were found in patients with hyperkeratotic eczema (17/22; 77% good clinical response) followed by patients with palmoplantar psoriasis (26/41; 63%) and patients with dyshidrotic eczema (8/16; 50%). Oral vs. bath PUVA using 8-methoxypsoralen for chronic palmoplantar eczema. Bo... | yes |
58ca906a02b8c6095300002e | Do brown fat cells produce heat? | WAT and BAT are both involved in energy balance. WAT is mainly involved in the storage and mobilization of energy in the form of triglycerides, whereas BAT specializes in dissipating energy as heat during cold- or diet-induced thermogenesis. Because brown adipose tissue (BAT) dissipates energy in the form of heat, incr... | yes |
58caf88c02b8c60953000031 | Is Melioidosis caused by the bacterium Burkholderia pseudomallei? | Burkholderia pseudomallei, the causative agent of melioidosis, What drives the occurrence of the melioidosis bacterium Burkholderia pseudomallei in domestic gardens? Landscape changes influence the occurrence of the melioidosis bacterium Burkholderia pseudomallei in soil in northern Australia. Out of the ground: aerial... | yes |
588482f5e56acf517600000a | Can glyburide reduce cerebral edema? | Preclinical studies have shown that a continuous infusion of glyburide blocks edema formation and improves outcome. We hypothesize that treatment with RP-1127 (Glyburide for Injection) reduces formation of brain edema in patients after large anterior circulation infarction. CONCLUSIONS: GAMES-RP was designed to provide... | yes |
58848ea5e56acf517600000e | Is vemurafenib used for thyroid cancer? | Vemurafenib in patients with BRAF(V600E)-positive metastatic or unresectable papillary thyroid cancer refractory to radioactive iodine: a non-randomised, multicentre, open-label, phase 2 trial. Vemurafenib, an oncogenic BRAF kinase inhibitor approved for BRAF-positive melanoma, showed clinical benefit in three patients... | yes |
58e11bf76fddd3e83e00000c | Are mutations in the C9orf72 gene associated with macular degeneration? | Over the years, however, growing evidence from clinical, pathological and genetic findings has suggested that ALS and FTD belong to the same clinic-pathological spectrum disorder. This concept has been further supported by the identification of the most common genetic cause for both diseases, an aberrantly expanded hex... | no |
58e26ede6fddd3e83e000015 | Is the number of described human nuclear mutations less than 50000? | The number of known mutations in human nuclear genes, underlying or associated with human inherited disease, has now exceeded 100,000 in more than 3700 different genes (Human Gene Mutation Database). The Human Gene Mutation Database (HGMD®) is a comprehensive collection of germline mutations in nuclear genes that under... | no |
58df779d6fddd3e83e000001 | Is Musclin a secretory peptide? | Musclin is a novel skeletal muscle-derived secretory factor, Musclin has been described as a muscle-derived secretory peptide, responsive to insulin in vivo, and inducing insulin resistance in vitro. Musclin is a type of muscle-secreted cytokine and its increased gene expression induces insulin resistance in type 2 dia... | yes |
58e11b9b6fddd3e83e00000b | Are cutaneous porphyrias inherited with a recessive pattern? | Five of the porphyrias are low-penetrance autosomal dominant conditions in which clinical expression results from additional factors that act by increasing demand for haem or by causing an additional decrease in enzyme activity or by a combination of these effects Molecular mechanisms of dominant expression in porphyri... | no |
5884755ce56acf5176000007 | Can valproic acid prolong survival of glioblastoma patients? | For patients who presented with epilepsy, the use of the antiepileptic drug VPA did not associate with survival when compared with patients who did not receive VPA treatment. This prognostic effect is not solely explained by early diagnosis, and survival is not associated with VPA treatment. Several in vivo and in vitr... | yes |
58e120036fddd3e83e00000d | Is Cryptococcus neoformans a frequent cause of isolated skin infections in immunocompromised individuals | Cryptococcus is an opportunistic yeast with a worldwide distribution that primarily causes significant infections in immunocompromised individuals, generally by affecting the respiratory tract. But primary cutaneous cryptococcosis (PCC) without systemic infection is rare. Cryptococcus is a ubiquitous fungus and is kno... | no |
5884722ee56acf5176000006 | Is Obeticholic Acid used for treatment of Primary Biliary Cholangitis? | Obeticholic acid in primary biliary cholangitis. In a double-blind, randomized, placebo-controlled study including 217 patients with primary biliary cholangitis, the authors show that obeticholic acid (a potent farnesoid X agonist) administered with ursodeoxycholic acid or as monotherapy significantly decreases serum a... | yes |
58e186fd6fddd3e83e00000f | Does the word ovine refers to goats? | Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep that has rarely been found in goats. In sheep, a bronchiolo-alveolar carcinoma, known as ovine pulmonary carcinoma (OPC), is caused by jaagsiekte sheep retrovirus (JSRV), an exogenous... | no |
58e782fd3e8b6dc87c000006 | Does GATA-1 regulate ribosomal protein genes? | Mutations in exon 2 interfere with the synthesis of the full-length isoform of GATA-1 and lead to the production of a shortened isoform, GATA-1s. These mutations have been found in patients with Diamond-Blackfan anemia (DBA), a congenital erythroid aplasia typically caused by mutations in genes encoding ribosomal prote... | yes |
58dbb4f08acda3452900001a | Is Lennox-Gastaut Syndrome usually diagnosed in older adults? | We studied 15 LGS patients (mean age ± 1 standard deviation [SD] = 28.7 ± 10.6 years) and 17 healthy controls (mean age ± 1 SD = 27.6 ± 6.6 years) children with Lennox-Gastaut syndrome Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by mixed seizures, cognitive decline, and generali... | no |
58d90f228acda3452900000f | Is diphosphatidylglycerol (cardiolipin) a phospholipid of the mitochondrial membranes? | A unique organelle for studying membrane biochemistry is the mitochondrion whose functionality depends on a coordinated supply of proteins and lipids. Mitochondria are capable of synthesizing several lipids autonomously such as phosphatidylglycerol, cardiolipin and in part phosphatidylethanolamine, phosphatidic acid an... | yes |
58e2422c6fddd3e83e000011 | Have studies shown that there is no link between DNA methylation patterns and Post Traumatic Stress Disorder? | Using pre-deployment SKA2 methylation levels and childhood trauma exposure, we found that the previously published suicide prediction rule significantly predicted post-deployment PTSD symptoms (AUC=0.66, 95% CI: 0.53-0.79) with an optimal sensitivity of 0.81 and specificity of 0.91. Permutation analysis using random me... | no |
5883b8e6e56acf5176000002 | Is POLD3 essential for mouse development? | The Pold3 gene encodes a subunit of the Polδ DNA polymerase complex. Pold3 orthologs are not essential in Saccharomyces cerevisiae or chicken DT40 cells, but the Schizosaccharomyces pombe ortholog is essential. POLD3 also has a specialized role in the repair of broken replication forks, suggesting that POLD3 activity c... | yes |
58e3d1743e8b6dc87c000001 | Are hepadnaviral minichromosomes free of nucleosomes? | Several nucleosome-protected sites in a region of the DHBV genome [nucleotides (nt) 2000 to 2700], known to harbor various cis transcription regulatory elements, were consistently identified in all DHBV-positive liver samples. In addition, we observed other nucleosome protection sites in DHBV minichromosomes that may v... | no |
58dff5776fddd3e83e000008 | Is it feasible to obtain DNA read lengths that exceed 30 Kb? | Single-molecule, real-time sequencing (SMRT) developed by Pacific BioSciences produces longer reads than secondary generation sequencing technologies such as Illumina. The long read length enables PacBio sequencing to close gaps in genome assembly, reveal structural variations, and identify gene isoforms with higher ac... | no |
58df73bd38f7f3e93a000001 | Is osteocrin expressed exclusively in the bone? | Evolution of Osteocrin as an activity-regulated factor in the primate brain. Here we use transcriptional profiling of human fetal brain cultures to identify an activity-dependent secreted factor, Osteocrin (OSTN), that is induced by membrane depolarization of human but not mouse neurons. Osteocrin (Ostn) is a recently ... | no |
587e1e57fc7e8dd84f000003 | Are alterations in ultraconserved elements associated with colorectal adenocarcinoma? | Genetic variants within ultraconserved elements and susceptibility to right- and left-sided colorectal adenocarcinoma Our results strongly suggest that several genetic variants in the UCEs may contribute to CRC susceptibility, individually and jointly, and that different genetic etiology may be involved in RCRC and LCR... | yes |
589a246d78275d0c4a000033 | Is apremilast effective for psoriasis? | CONCLUSION: Apremilast reduces the severity of nail/scalp psoriasis. CONCLUSIONS: Apremilast demonstrated clinically meaningful improvements in psoriatic arthritis and psoriasis at week 16; sustained improvements were seen with continued treatment through 52 weeks. Apremilast: A Novel Drug for Treatment of Psoriasis an... | yes |
58ef9ff170f9fc6f0f000002 | Is skin color affected by variations of the SLC24A5 gene? | the alleles of single-nucleotide polymorphisms rs1426654 and rs1834640 (SLC24A5) associated with light skin pigmentation in Eurasian populati Associations between five single nucleotide polymorphisms (SNPs) known to play a role in pigmentation (rs1426654-SLC24A5, rs1042602-TYR, rs16891982-SLC45A2, rs6058017-ASIP, and r... | yes |
58dd054c8acda34529000024 | Do circRNAs remain untranslated? | We demonstrate that the circular RNA circ-Foxo3 was highly expressed in non-cancer cells and were associated with cell cycle progression Ectopic expression of circ-Foxo3 repressed cell cycle progression by binding to the cell cycle proteins cyclin-dependent kinase 2 (also known as cell division protein kinase 2 or CDK2... | no |
58dd2cb08acda34529000029 | Is autophagy the process where bacteria ingest viral particles? | Autophagy, a cellular degradation process Autophagy, a form of lysosomal degradation capable of eliminating dysfunctional proteins and organelles, is a cellular process associated with homeostasis. Autophagy, a programmed process in which cell contents are delivered to lysosomes for degradation, appears to have both tu... | yes |
589a245478275d0c4a000022 | Is intraoperative radiotherapy used for treatment of glioblastoma? | 1) Intraoperative radiotherapy ( IOR , 1,000-2,000 rad) was applied in 13 cases; the 2-year survival was 41.6%. The median survival time after IORT was 12 months for 9 patients with glioblastoma or anaplastic astrocytoma, while it was 51 months for 8 patients with less infiltrative tumors (ependymoma, anaplastic epend... | no |
58ec72a4eda5a5767200000f | Is tirilazad effective for treatment of aneurysmal subarachnoid haemorrhage? | There was no significant difference between the two groups at the end of follow up for the primary outcome, death (odds ratio (OR) 0.89, 95% confidence interval (CI) 0.74 to 1.06), or in poor outcome (death, vegetative state or severe disability) (OR 1.04, 95% CI 0.90 to 1.21). During the treatment period, fewer patien... | no |
58ec5ffaeda5a5767200000a | Is dexamethasone recommended for treatment of intracerebral hemorrhage? | Dexamethasone and other glucocorticoids should be avoided. During the third interim analysis, the death rate at the 21st day was identical in the two groups (dexamethasone vs. placebo, 21 of 46 vs. 21 of 47; chi-square = 0.01, P = 0.93). In contrast, the rate of complications (mostly infections and complications of di... | no |
58ec613ceda5a5767200000b | Is airplane stroke syndrome a common disease. | Only 37 cases of stroke during or soon after long-haul flights have been published to our knowledge. Our centre admitted 5727 stroke patients, of whom 42 (0.73%) had flight-related strokes. The authors report three cases of ischemic stroke in young adults that occurred during or after an airplane flight. | no |
5890e762621ea6ff7e000005 | Can acupuncture cause spinal epidural hematoma? | RESULTS: A 54-year-old woman, a 38-year-old woman, and a 60-year-old man with hemiplegia by cervical subdural or epidural hematoma after cervical posterior paraspinal muscle needling without direct invasion (intramuscular stimulation, acupuncture, or intramuscular lidocaine) were observed. Acute spinal subdural hematom... | yes |
58da270d8acda34529000013 | Is edema a symptom of nephrotic syndrome? | Nephrotic syndrome (NS) is a common clinical disease with four main clinical manifestations: hypoalbuminemia (<30 g/L), macro-proteinuria (>3.5 g/24 h), edema, and hyperlipidemia. Nephrotic syndrome is an unusual manifestation of IgA Nephropathy (IgAN). Twelve patients with IgAN with steroid-responsive nephrotic syndr... | yes |
5890ede0621ea6ff7e000007 | Is there an association between Histone H3.3 mutations and glioma? | PURPOSE: Histone H3.3 (H3F3A) mutation in the codon for lysine 27 (K27M) has been found as driver mutations in pediatric glioblastoma and has been suggested to play critical roles in the pathogenesis of thalamic gliomas and diffuse intrinsic pontine gliomas. We report a case of thalamic glioma with H3F3A K27M mutation,... | yes |
5881e8e8713cbdfd3d000003 | Is Pfh1 a component of the replisome? | Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity Although the Schizosaccharomyces pombe 5'-to-3' DNA helicase Pfh1 is known to promote fork progression, its genomic targets, dynamics, and mechanisms of action are largely unknown. He... | no |
58db94948acda34529000017 | Does the Abelson-related gene (ARG) gene encode for a serine kinase? | One isoform of Arg/Abl2 tyrosine kinase is nuclear and the other seven cytosolic isoforms differently modulate cell morphology, motility and the cytoskeleton. The non-receptor tyrosine kinase Abelson related gene (Arg/Abl2) regulates cell migration and morphogenesis by modulating the cytoskeleton. The human Arg (Abl2)... | no |
58ea659c3e8b6dc87c000013 | Is Prochlorococcus the most abundant photosynthetic organism? | The marine cyanobacterium Prochlorococcus is the smallest and most abundant photosynthetic organism on Earth. The marine cyanobacterium Prochlorococcus is the numerically dominant photosynthetic organism in the oligotrophic oceans, and a model system in marine microbial ecology. The marine cyanobacterium Prochlorococcu... | yes |
58df5efbc784871774000001 | Is dupilumab an antibody targeting the IL-1 receptor? | Atopic dermatitis (AD) is characterized by type 2 helper T (Th2) cell-driven inflammation. Dupilumab is a fully human monoclonal antibody directed against the IL-4 receptor α subunit that blocks the signaling of IL-4 and IL-13, both key cytokines in Th2-mediated pathways. Dupilumab, a humanized monoclonal antibody to t... | no |
58f3cd1470f9fc6f0f00000e | Is Hepatic mesenchymal hamartoma usually a malignant tumor? | Mesenchymal hamartoma of the liver (MHL) is a benign and rare hepatic lesion, Mesenchymal hamartoma of the liver (MHL) is an uncommon benign hepatic tumor typically affecting children under 2 years of age This review on the pathology of hepatic tumors in childhood, from a personal series of 245 tumors, focuses on inci... | no |
58f0b40d70f9fc6f0f000008 | Are selenium supplements recommended for prostate cancer prevention? | Our meta-analysis in prospective studies demonstrated a significant inverse association between selenium status and CVD risk within a narrow selenium range and a null effect of selenium supplementation on CVD was observed in RCTs. These findings indicate the importance of considering selenium status, dose and safety in... | no |
58965a4178275d0c4a00000e | Is there any involvement of L1 retrotransposition in the Rett syndrome? | Using neuronal progenitor cells derived from human induced pluripotent stem cells and human tissues, we revealed that patients with Rett syndrome (RTT), carrying MeCP2 mutations, have increased susceptibility for L1 retrotransposition. Our data demonstrate that L1 retrotransposition can be controlled in a tissue-specif... | yes |
58f3d85170f9fc6f0f00000f | Is Downs syndrome associated with decreased risk of leukemia? | The association of Down's syndrome and leukemia has been documented for over 50 years. Multiple studies have established the incidence of leukemia in Down's syndrome patients to be 10- to 20-fold higher than that in the general population. We present a case of congenital acute myeloid leukemia manifesting from the very... | no |
58db9aa28acda34529000018 | Does PCSK9 (Proprotein convertase subtilisin/kexin type 9) binds with HDL-receptor (HDL-R)? | Recently it was revealed that the secreted Proprotein Convertase Subtilisin Kexin 9 (PCSK9) binds with LDL-receptor (LDL-R) causing its degradation in the lysosome with the result of LDL-C accumulating in the blood. The major goal of this study is to identify peptide/s from the catalytic domain of hPCSK9 that can block... | no |
5896e22078275d0c4a000014 | Is apremilast effective for psoriatic arthritis? | Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement: a phase III, randomised, controlled trial (PALACE 3). OBJECTIVE: To evaluate apremilast treatment in patients with active psoriatic arthritis, including current skin involvement, despite prior therapy w... | yes |
58965ed478275d0c4a000010 | Is there any role of TBR1 in autism? | TBR1 regulates autism risk genes in the developing neocortex Exome sequencing studies have identified multiple genes harboring de novo loss-of-function (LoF) variants in individuals with autism spectrum disorders (ASD), including TBR1, a master regulator of cortical development. We performed ChIP-seq for TBR1 during mo... | yes |
589a246f78275d0c4a000034 | Is sonidegib effective for basal cell carcinoma? | This review of the literature aims to describe previous and current treatment options for oral therapy in locally advanced and metastatic NMSC otherwise unamenable to standard treatment. Oral Smoothened (Smo) inhibitors Vismodegib, Sonidegib, and Taladegib have shown to be effective in several trials. Sonidegib is a n... | yes |
5a4e1882966455904c00000f | Is there a sequence bias in MNase digestion patterns? | In addition, unlike MNase, MPE-Fe(II) cleaves nuclear DNA with little sequence bias. These findings collectively indicate that MPE-seq provides a unique and straightforward means for the genome-wide analysis of chromatin structure with minimal DNA sequence bias. Micrococcal nuclease does not substantially bias nucleoso... | yes |
5a8a9f18fcd1d6a10c00001a | Is NEMO a zinc finger protein? | To better understand the thermodynamics and dynamics of the zinc finger of NEMO (NF-κB essential modulator) an alteration in the zinc finger domain of NEMO (K392R) CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis. our simulations of the zinc finger NEMO An important regula... | yes |
5a3566bb966455904c000003 | Does TFIIS affect nucleosome positioning? | Transcript cleavage factor TFIIS reactivates the backtracked complexes and promotes pol II transcription through the nucleosome. The same nucleosomes transcribed in the opposite orientation form a weaker, more diffuse barrier that is largely relieved by higher salt, TFIIS, or FACT The system contains natural or recomb... | yes |
5a68f2bab750ff4455000017 | Is tretinoin effective for photoaging? | Background. Tretinoin has been shown to improve photoaged skin. This study was designed to evaluate the efficacy and tolerability of a 5% retinoic acid peel combined with microdermabrasion for facial photoaging. .Conclusion. This study demonstrated that 5% retinoic acid peel cream combined with microdermabrasion was sa... | yes |
5a6d23ccb750ff4455000035 | Does TUC.338 inhibit colorectal cancer? | TUC.338 promotes invasion and metastasis in colorectal cancer. Until now, the role of TUC.338 in colorectal cancers remains undefined. This study revealed that TUC.338 is significantly up-regulated in colorectal cancers (CRC) tissue and CRC cell lines, and the up-regulated TUC.338 is associated with lymph node metastas... | no |
5a7626989e632bc066000001 | Has ruxolitinib received FDA approval? | Testing for JAK2 mutations is now included in the World Health Organization (WHO) criteria for the diagnosis of MPN, and in 2011 the oral JAK2 kinase inhibitor ruxolitinib became the first Food and Drug Administration (FDA)-approved drug for the treatment of myelofibrosis. | yes |
5a7726989e632bc06600000c | Does deflazacort have more side effects than prednisone? | Though Deflazacort and prednisone improve clinical endpoints in Duchenne muscular dystrophy (DMD) patients, Deflazacort produces fewer side effects. | no |
5a67a049b750ff4455000007 | Does echinacea increase anaphylaxis risk? | Chicoric acid (dicaffeoyl-tartaric acid), is a natural phenolic compound found in a number of plants, such as chicory (Cichorium intybus) and Echinacea (Echinacea purpurea), which possesses antioxidant, anti-inflammatory, antiviral, and analgesic activities. Although these biological effects of chicoric acid have been ... | yes |
5a8866958cb19eca6b000003 | Are neurexins localized at pre-synapses? | Neurexins and neuroligins are two distinct families of single-pass transmembrane proteins localized at pre- and postsynapses, respectively. presynaptic neurexins best-characterized transsynaptic interactions are formed by presynaptic neurexins, which bind to diverse postsynaptic ligands. presynaptic neurexin | yes |
5a6d0727b750ff445500002b | Is there any role of 5hmC in T-cell development and differentiation? | We have mapped 5-hydroxymethylcytosine (5hmC) at different stages of T-cell development in the thymus and T-cell differentiation in the periphery. We show that 5hmC is enriched in the gene body of highly expressed genes at all developmental stages and that its presence correlates positively with gene expression. Furthe... | yes |
5a6d217eb750ff4455000034 | Are there ultraconserved genomic regions in the budding yeast? | Here, we present a systematic study of ultraconserved genomic regions in the budding yeast based on the publicly available genome sequences, in order to reveal their relationship with the adaptability or fitness advantages of the budding yeast.Results: Our results indicate that, in addition to some fundamental biologic... | yes |
5a7d5033faa1ab7d2e000015 | Is davunetide being considered for the treatment of progressive supranuclear palsy? | Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy. Davunetide's efficacy and tolerability are being tested in a placebo-controlled study in PSP patients, making it the most advanced drug candidate in this indication. This review examines the disease characteristics of PSP, ... | yes |
5a87fd0561bb38fb24000010 | Is autophagy modulated in a circadian fashion? | TOR signaling pathway and autophagy are involved in the regulation of circadian rhythms in behavior and plasticity of L2 interneurons in the brain of Drosophila melanogaster. Our results indicate that the TOR signaling pathway and autophagy are involved in the regulation of circadian rhythms in the behavior and plasti... | yes |
5a7607f683b0d9ea66000014 | Is Drk essential for anesthesia-resistant memory (ARM) in Drosophila? | Anesthesia-resistant memory (ARM) was described decades ago, but the mechanisms that underlie this protein synthesis-independent form of consolidated memory inDrosophilaremain poorly understood. Whether the several signaling molecules, receptors, and synaptic proteins currently implicated in ARM operate in one or more ... | yes |
58ee1cafeda5a57672000014 | Are TAD boundaries in Drosophila depleted in highly-expressed genes? | Furthermore, we find that these TAD boundaries are present irrespective of the expression and looping of genes located between them. In particular, Hi-C revealed that chromosomes of animals are organized into topologically associating domains (TADs), evolutionary conserved compact chromatin domains that influence gene ... | no |
5a774ce1faa1ab7d2e000006 | Is there increased recombination rate in human regulatory domains? | Evidence of reduced recombination rate in human regulatory domains. We study the relationship between recombination rate and gene regulatory domains, defined by a gene and its linked control elements. We define these links using expression quantitative trait loci (eQTLs), methylation quantitative trait loci (meQTLs), c... | no |
5a7612b483b0d9ea6600001d | Is enzastaurin effective treatment of glioblastoma? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
5a760ed883b0d9ea66000019 | Is dasatinib effective for treatment of glioblastoma? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
5a7d54adfaa1ab7d2e000019 | Has IVIG been tested in clinical trials for the treatment of Alzheimer's disease? | Clinical trials of intravenous immunoglobulin for Alzheimer's disease. Preclinical and clinical studies have shown that IVIG has anti-amyloid and immune modulatory properties relevant to treating neurodegenerative disorders. In early stage AD clinical trials, IVIG was found to reduce cognitive decline and increase brai... | yes |
59bf823b542ba3824b000001 | Does a tonsillectomy affect the patient's voice? | Group B had a better awareness of tooth damage (78% vs 30% of patients, P ≤ .001), voice change (61 vs 19%, P = .005), and burns to lips and mouth (44% vs 8%, P = .005). Finally, 35% more patients from group B rated their understanding of tonsillectomy as good or very good (P = .017). Some patients complaint for dry t... | yes |
58e8a2fc3e8b6dc87c00000c | Do cephalopods use RNA editing less frequently than other species? | Extensive messenger RNA editing generates transcript and protein diversity in genes involved in neural excitability, as previously described, as well as in genes participating in a broad range of other cellular functions By adopting a method originally designed to detect linkage disequilibrium of DNA mutations, we exam... | no |
5a7357e63b9d13c708000001 | Is there an RNAi drug being developed to treat amyloidosis? | Patisiran is an investigational RNA interference (RNAi) therapeutic in development for the treatment of hereditary ATTR (hATTR) amyloidosis, a progressive disease associated with significant disability, morbidity, and mortality. | yes |
5a74a4be0384be9551000004 | Are there RNAi approaches considered for the treatment of kidney injury? | Herein, we describe ammonium-functionalized carbon nanotube (fCNT)-mediated transport of siRNA selectively and with high efficiency to renal proximal tubule cells in animal models of acute kidney injury (AKI). fCNT enhanced siRNA delivery to tubule cells compared to siRNA alone and effectively knocked down the expressi... | yes |
5a67a72fb750ff445500000a | Is propranolol used for treatment of infantile hemangioma? | Low-dose propranolol for infantile hemangioma of the head and neck: Analysis of 23 consecutive patients. BACKGROUND: More and more infantile hemangiomas (IH) are being treated with propranolol, but the effectiveness, dosage, and treatment course are still in dispute. CONCLUSIONS: Low-dose propranolol appears to be effe... | yes |
5a75fec383b0d9ea6600000b | Can the CEP290 gene mutations be targeted by AAV-mediated gene therapy? | The large size of the CEP290 gene prevents its use in adeno-associated virus (AAV)-mediated gene augmentation therapy. | no |
5a87efa961bb38fb2400000e | Are mutations in the nf1 gene associated with memory? | We hypothesized that NF1 mutations disturb the expression of genes important for memory formation Our previous work has shown that defective cAMP signaling leads to the learning phenotype in Drosophila Nf1 mutants. In the present report, our experiments showed that in addition to learning, long-term memory was also abo... | yes |
5a7d50d0faa1ab7d2e000016 | Is ACI-35 a passive vaccine? | Two active vaccines targeting either nonphosphorylated (AAD-vac1) and phosphorylated tau (ACI-35) have entered Phase I testing. | no |
5a43a214966455904c000009 | Is DNA methylation correlated with nucleosome occupancy? | Here I show that CpG islands were associated not only with methylation-free promoters but also with nucleosome-free promoters. Nucleosome-free regions were observed only in promoters containing a CpG island In contrast to the methylation-and nucleosome-free states of CpG-island promoters, exons were densely methylated ... | yes |
5a76056983b0d9ea66000012 | Does DDX54 play a role in DNA damage response? | DDX54 regulates transcriptome dynamics during DNA damage response. The contribution of post-transcriptional gene regulatory networks to the DNA damage response (DDR) has not been extensively studied. Here, we systematically identified RNA-binding proteins differentially interacting with polyadenylated transcripts upon ... | yes |
5a68a463b750ff4455000014 | Do chromatin features predict genes associated with eQTLs? | Using the random forest classifier, we found that genomic proximity plus five TF and chromatin features are able to predict>90% of target genes within 1 megabase of eQTLs Using the random forest classifier, we found that genomic proximity plus five TF and chromatin features are able to predict >90% of target genes with... | yes |
5a787544faa1ab7d2e00000b | Is Kummell’s disease an avascular necrosis of the vertebral body? | Kummell's disease is an avascular necrosis of the vertebral body, secondary to a vertebral compression fracture. This entity is characterised by the gradual development in time of a vertebral body collapse following a trivial spinal trauma, involving a worsening back pain associated with a progressive kyphosis. Kummell... | yes |
5a6e18d8b750ff4455000038 | Are Conserved Nonexonic Elements (CNEEs) important in phylogenomics research? | Overall, CNEEs appear to be promising as phylogenomic markers, yielding phylogenetic resolution as high as for UCEs and introns but with fewer gaps, less ambiguity in alignments and with patterns of nucleotide substitution more consistent with the assumptions of commonly used methods of phylogenetic analysis. Conserved... | yes |
5a857bfffaa1ab7d2e000030 | Can the yeast protein Abf1 act as insulator? | Saccharomyces cerevisiae Rap1p and Abf1p proteins are endowed with a potent insulating capacity Insulating domains in Rap1p coincide with previously described transcription activation domains, whereas four adjacent subdomains spanning the whole of the Abf1p C terminus (440-731) were found to display autonomous insulati... | yes |
5a6d022ab750ff445500002a | Is there any linear-time and linear-space algorithm for the computation of avoided words in biological sequences? | The systematic search for avoided words is particularly useful for biological sequence analysis. We present a linear-time and linear-space algorithm for the computation of avoided words of lengthkin a given sequencex. We suggest a modification to this algorithm so that it computes all avoided words ofx, irrespective of... | yes |
5a86fd5bfaa1ab7d2e00003b | Is a CpG island methylator phenotype involved in ependymomas? | Although devoid of recurrent single nucleotide variants and focal copy number aberrations, poor-prognosis hindbrain ependymomas exhibit a CpG island methylator phenotype Although no recurrently mutated genes were found throughout these groups of ependymomas, PFA exhibited a CpG island methylator phenotype, PFB was asso... | yes |
5a6e4814b750ff445500004a | Are loop domains preserved upon cohesin loss? | Cohesin Loss Eliminates All Loop Domains. The human genome folds to create thousands of intervals, called "contact domains," that exhibit enhanced contact frequency within themselves. "Loop domains" form because of tethering between two loci-almost always bound by CTCF and cohesin-lying on the same chromosome. "Compart... | no |
5a86e66dfaa1ab7d2e000035 | Does the association of PARP1 and CTCF follow a circadian rhythm? | here we uncovered an inter-chromosomal network connecting active loci enriched in circadian genes to repressed lamina-associated domains (LADs). Synchronization of the circadian rhythm by serum shock induces oscillations in PARP1-CTCF interactions, which is accompanied by oscillating recruitment of circadian loci to th... | yes |
5a772e9dfaa1ab7d2e000001 | Was saracatinib being considered as a treatment for Alzheimer's disease in November 2017? | A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease. Herein, we present a Phase Ib trial of the repurposed investigational drug AZD0530, a Src family kinase inhibitor specific for Fyn and Src kinase, for the treatm... | yes |
5a89537cfcd1d6a10c000002 | Are mouse chromosomes acrocentric? | Based on combined fluorescence in situ hybridization and linkage mapping, the gene order on CFA9 is similar to that of the homologous genes on HSA17q and mouse chromosome 11 (MMU11), but in the dog the gene order is inverted with respect to the centromere. In murine models of human carcinogenesis, however, karyotype a... | yes |
5a6e47b1b750ff4455000049 | Is overproduction of transthyretin is associated with amyloidosis associated neuropathy? | Transthyretin-associated familial amyloid polyneuropathy (TTR-FAP) is a disease caused by the deposit of abnormal transthyretin on tissues, mainly nerves transthyretin familial amyloid polyneuropathy We report a new transthyretin (ATTR) gene c.272C>G mutation and variant protein, p.Leu32Val, in a kindred of Bolivian or... | yes |
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